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dc.contributor.authorFlaus, A
dc.contributor.authorDowns, JA
dc.contributor.authorOwen-Hughes, T
dc.date.accessioned2021-03-03T09:10:30Z
dc.date.available2021-12-04T00:00:00Z
dc.date.issued2020-12-04
dc.identifier.citationCurrent opinion in genetics & development, 2020, 67 pp. 61 - 66en_US
dc.identifier.issn0959-437X
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4388
dc.identifier.eissn1879-0380en_US
dc.identifier.eissn1879-0380
dc.identifier.doi10.1016/j.gde.2020.11.003en_US
dc.identifier.doi10.1016/j.gde.2020.11.003
dc.description.abstractRecent studies have highlighted the potential for missense mutations in histones to act as oncogenic drivers, leading to the term 'oncohistones'. While histone proteins are highly conserved, they are encoded by multigene families. There is heterogeneity among these genes at the level of the underlying sequence, the amino acid composition of the encoded histone isoform, and the expression levels. One question that arises, therefore, is whether all histone-encoding genes function equally as oncohistones. In this review, we consider this question and explore what this means in terms of the mechanisms by which oncohistones can exert their effects in chromatin.en_US
dc.formatPrint-Electronicen_US
dc.format.extent61 - 66en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
dc.titleHistone isoforms and the oncohistone code.en_US
dc.typeJournal Article
dcterms.dateAccepted2020-11-07
rioxxterms.versionAMen_US
rioxxterms.versionofrecord10.1016/j.gde.2020.11.003en_US
rioxxterms.licenseref.startdate2020-12-04
dc.relation.isPartOfCurrent opinion in genetics & developmenten_US
pubs.notes12 monthsen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Epigenetics and Genome Stability
pubs.publication-statusPublisheden_US
pubs.volume67en_US
pubs.embargo.terms12 monthsen_US
pubs.embargo.date2021-12-04T00:00:00Z
icr.researchteamEpigenetics and Genome Stability
dc.contributor.icrauthorDowns, Jessicaen_US


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