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dc.contributor.authorFlaus, A
dc.contributor.authorDowns, JA
dc.contributor.authorOwen-Hughes, T
dc.date.accessioned2021-03-03T09:10:30Z
dc.date.available2021-12-04T00:00:00Z
dc.date.issued2020-12-04
dc.identifier.citationCurrent opinion in genetics & development, 2020, 67 pp. 61 - 66
dc.identifier.issn0959-437X
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4388
dc.identifier.eissn1879-0380
dc.identifier.doi10.1016/j.gde.2020.11.003
dc.description.abstractRecent studies have highlighted the potential for missense mutations in histones to act as oncogenic drivers, leading to the term 'oncohistones'. While histone proteins are highly conserved, they are encoded by multigene families. There is heterogeneity among these genes at the level of the underlying sequence, the amino acid composition of the encoded histone isoform, and the expression levels. One question that arises, therefore, is whether all histone-encoding genes function equally as oncohistones. In this review, we consider this question and explore what this means in terms of the mechanisms by which oncohistones can exert their effects in chromatin.
dc.formatPrint-Electronic
dc.format.extent61 - 66
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
dc.titleHistone isoforms and the oncohistone code.
dc.typeJournal Article
dcterms.dateAccepted2020-11-07
rioxxterms.versionAM
rioxxterms.versionofrecord10.1016/j.gde.2020.11.003
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.licenseref.startdate2020-12-04
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCurrent opinion in genetics & development
pubs.notes12 months
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Epigenetics and Genome Stability
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Epigenetics and Genome Stability
pubs.publication-statusPublished
pubs.volume67en_US
pubs.embargo.terms12 months
pubs.embargo.date2021-12-04T00:00:00Z
pubs.embargo.date2021-12-04T00:00:00Z
icr.researchteamEpigenetics and Genome Stability
icr.researchteamEpigenetics and Genome Stabilityen_US
dc.contributor.icrauthorDowns, Jessicaen


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