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Histone isoforms and the oncohistone code.

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Accepted version (972.5Kb)
Publication Date
2020-12-04
ICR Author
Downs, Jessica
Author
Flaus, A
Downs, JA
Owen-Hughes, T
Type
Journal Article
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Abstract
Recent studies have highlighted the potential for missense mutations in histones to act as oncogenic drivers, leading to the term 'oncohistones'. While histone proteins are highly conserved, they are encoded by multigene families. There is heterogeneity among these genes at the level of the underlying sequence, the amino acid composition of the encoded histone isoform, and the expression levels. One question that arises, therefore, is whether all histone-encoding genes function equally as oncohistones. In this review, we consider this question and explore what this means in terms of the mechanisms by which oncohistones can exert their effects in chromatin.
URL
https://repository.icr.ac.uk/handle/internal/4388
Collections
  • Cancer Biology
Licenseref URL
http://www.rioxx.net/licenses/under-embargo-all-rights-reserved
Version
AM
Version of record
10.1016/j.gde.2020.11.003
Research team
Epigenetics and Genome Stability
Language
eng
Date accepted
2020-11-07
License start date
2020-12-04
Citation
Current opinion in genetics & development, 2020, 67 pp. 61 - 66

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