Histone isoforms and the oncohistone code.
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Date
2020-12-04ICR Author
Author
Flaus, A
Downs, JA
Owen-Hughes, T
Type
Journal Article
Metadata
Show full item recordAbstract
Recent studies have highlighted the potential for missense mutations in histones to act as oncogenic drivers, leading to the term 'oncohistones'. While histone proteins are highly conserved, they are encoded by multigene families. There is heterogeneity among these genes at the level of the underlying sequence, the amino acid composition of the encoded histone isoform, and the expression levels. One question that arises, therefore, is whether all histone-encoding genes function equally as oncohistones. In this review, we consider this question and explore what this means in terms of the mechanisms by which oncohistones can exert their effects in chromatin.
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Research team
Epigenetics and Genome Stability
Epigenetics and Genome Stability
Language
eng
Date accepted
2020-11-07
License start date
2020-12-04
Citation
Current opinion in genetics & development, 2020, 67 pp. 61 - 66
Publisher
CURRENT BIOLOGY LTD