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Systemic Therapy of Common Tumours in Older Patients: Challenges and Opportunities. A Young International Society of Geriatric Oncology Review Paper.

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Publication Date
2020-07-28
ICR Author
Battisti, Nicolo
Author
Battisti, NML
Liposits, G
De Glas, NA
Gomes, F
Baldini, C
Mohile, S
Type
Journal Article
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Abstract
<h4>Purpose of review</h4>Decision-making for systemic treatments in older patients with cancer is difficult because of concerns for decreased organ function, risk of toxicity, limited life expectancy due to comorbidities and the lack of evidence available to guide its management in this population. Here, we review the data on the role of systemic agents for the treatment of common malignancies in this age group.<h4>Recent findings</h4>Evidence on the use of systemic treatments for older patients with cancer is increasing, especially for newer options including immune checkpoint inhibitors and targeted agents that provide comparable benefit in older and younger patients. Nonetheless, the risks for short- and long-term toxicities need to be considered. More research is warranted and represents a unique opportunity to increase the knowledge on cancer treatment for older adults. Healthy, older individuals should be considered for standard systemic treatment options, whereas those at risk based on geriatric assessments require adjusted plans. Geriatric assessments are key for decision-making.
URL
https://repository.icr.ac.uk/handle/internal/4459
Collections
  • Breast Cancer Research
Licenseref URL
http://www.rioxx.net/licenses/under-embargo-all-rights-reserved
Version
AM
Version of record
10.1007/s11912-020-00958-z
Research team
Breast Cancer Clinical Research
Language
eng
Date accepted
2020-07-28
License start date
2020-07-28
Citation
Current oncology reports, 2020, 22 (10), pp. 98 - ?

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