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dc.contributor.authorSteinberg, J
dc.contributor.authorSoutham, L
dc.contributor.authorRoumeliotis, TI
dc.contributor.authorClark, MJ
dc.contributor.authorJayasuriya, RL
dc.contributor.authorSwift, D
dc.contributor.authorShah, KM
dc.contributor.authorButterfield, NC
dc.contributor.authorBrooks, RA
dc.contributor.authorMcCaskie, AW
dc.contributor.authorBassett, JHD
dc.contributor.authorWilliams, GR
dc.contributor.authorChoudhary, JS
dc.contributor.authorWilkinson, JM
dc.contributor.authorZeggini, E
dc.date.accessioned2021-03-31T13:37:32Z
dc.date.available2021-03-31T13:37:32Z
dc.date.issued2021-02-26
dc.identifier.citationNature communications, 2021, 12 (1), pp. 1309 - ?
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4481
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/s41467-021-21593-7
dc.description.abstractOsteoarthritis causes pain and functional disability for over 500 million people worldwide. To develop disease-stratifying tools and modifying therapies, we need a better understanding of the molecular basis of the disease in relevant tissue and cell types. Here, we study primary cartilage and synovium from 115 patients with osteoarthritis to construct a deep molecular signature map of the disease. By integrating genetics with transcriptomics and proteomics, we discover molecular trait loci in each tissue type and omics level, identify likely effector genes for osteoarthritis-associated genetic signals and highlight high-value targets for drug development and repurposing. These findings provide insights into disease aetiopathology, and offer translational opportunities in response to the global clinical challenge of osteoarthritis.
dc.formatElectronic
dc.format.extent1309 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectOsteoarthritis
dc.subjectGenetic Predisposition to Disease
dc.subjectTranscription Factors
dc.subjectGene Expression Profiling
dc.subjectGene Expression Regulation
dc.subjectPhenotype
dc.subjectQuantitative Trait Loci
dc.subjectGenome-Wide Association Study
dc.subjectTranscriptome
dc.titleA molecular quantitative trait locus map for osteoarthritis.
dc.typeJournal Article
dcterms.dateAccepted2021-02-03
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41467-021-21593-7
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2021-02-26
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature communications
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR
pubs.publication-statusPublished
pubs.volume12
pubs.embargo.termsNot known
dc.contributor.icrauthorChoudhary, Jyotien


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