dc.contributor.author | Huynh-Le, M-P | |
dc.contributor.author | Fan, CC | |
dc.contributor.author | Karunamuni, R | |
dc.contributor.author | Thompson, WK | |
dc.contributor.author | Martinez, ME | |
dc.contributor.author | Eeles, RA | |
dc.contributor.author | Kote-Jarai, Z | |
dc.contributor.author | Muir, K | |
dc.contributor.author | Schleutker, J | |
dc.contributor.author | Pashayan, N | |
dc.contributor.author | Batra, J | |
dc.contributor.author | Grönberg, H | |
dc.contributor.author | Neal, DE | |
dc.contributor.author | Donovan, JL | |
dc.contributor.author | Hamdy, FC | |
dc.contributor.author | Martin, RM | |
dc.contributor.author | Nielsen, SF | |
dc.contributor.author | Nordestgaard, BG | |
dc.contributor.author | Wiklund, F | |
dc.contributor.author | Tangen, CM | |
dc.contributor.author | Giles, GG | |
dc.contributor.author | Wolk, A | |
dc.contributor.author | Albanes, D | |
dc.contributor.author | Travis, RC | |
dc.contributor.author | Blot, WJ | |
dc.contributor.author | Zheng, W | |
dc.contributor.author | Sanderson, M | |
dc.contributor.author | Stanford, JL | |
dc.contributor.author | Mucci, LA | |
dc.contributor.author | West, CML | |
dc.contributor.author | Kibel, AS | |
dc.contributor.author | Cussenot, O | |
dc.contributor.author | Berndt, SI | |
dc.contributor.author | Koutros, S | |
dc.contributor.author | Sørensen, KD | |
dc.contributor.author | Cybulski, C | |
dc.contributor.author | Grindedal, EM | |
dc.contributor.author | Menegaux, F | |
dc.contributor.author | Khaw, K-T | |
dc.contributor.author | Park, JY | |
dc.contributor.author | Ingles, SA | |
dc.contributor.author | Maier, C | |
dc.contributor.author | Hamilton, RJ | |
dc.contributor.author | Thibodeau, SN | |
dc.contributor.author | Rosenstein, BS | |
dc.contributor.author | Lu, Y-J | |
dc.contributor.author | Watya, S | |
dc.contributor.author | Vega, A | |
dc.contributor.author | Kogevinas, M | |
dc.contributor.author | Penney, KL | |
dc.contributor.author | Huff, C | |
dc.contributor.author | Teixeira, MR | |
dc.contributor.author | Multigner, L | |
dc.contributor.author | Leach, RJ | |
dc.contributor.author | Cannon-Albright, L | |
dc.contributor.author | Brenner, H | |
dc.contributor.author | John, EM | |
dc.contributor.author | Kaneva, R | |
dc.contributor.author | Logothetis, CJ | |
dc.contributor.author | Neuhausen, SL | |
dc.contributor.author | De Ruyck, K | |
dc.contributor.author | Pandha, H | |
dc.contributor.author | Razack, A | |
dc.contributor.author | Newcomb, LF | |
dc.contributor.author | Fowke, JH | |
dc.contributor.author | Gamulin, M | |
dc.contributor.author | Usmani, N | |
dc.contributor.author | Claessens, F | |
dc.contributor.author | Gago-Dominguez, M | |
dc.contributor.author | Townsend, PA | |
dc.contributor.author | Bush, WS | |
dc.contributor.author | Roobol, MJ | |
dc.contributor.author | Parent, M-É | |
dc.contributor.author | Hu, JJ | |
dc.contributor.author | Mills, IG | |
dc.contributor.author | Andreassen, OA | |
dc.contributor.author | Dale, AM | |
dc.contributor.author | Seibert, TM | |
dc.contributor.author | UKGPCS collaborators, | |
dc.contributor.author | APCB (Australian Prostate Cancer BioResource), | |
dc.contributor.author | NC-LA PCaP Investigators, | |
dc.contributor.author | IMPACT Study Steering Committee and Collaborators, | |
dc.contributor.author | Canary PASS Investigators, | |
dc.contributor.author | Profile Study Steering Committee, | |
dc.contributor.author | PRACTICAL Consortium, | |
dc.date.accessioned | 2021-03-31T14:07:59Z | |
dc.date.available | 2021-03-31T14:07:59Z | |
dc.date.issued | 2021-02-23 | |
dc.identifier.citation | Nature communications, 2021, 12 (1), pp. 1236 - ? | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4484 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.doi | 10.1038/s41467-021-21287-0 | |
dc.description.abstract | Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p < 10-180). Comparing the 80th/20th PHS2 percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS2 risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset. | |
dc.format | Electronic | |
dc.format.extent | 1236 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PORTFOLIO | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | UKGPCS collaborators | |
dc.subject | APCB (Australian Prostate Cancer BioResource) | |
dc.subject | NC-LA PCaP Investigators | |
dc.subject | IMPACT Study Steering Committee and Collaborators | |
dc.subject | Canary PASS Investigators | |
dc.subject | Profile Study Steering Committee | |
dc.subject | PRACTICAL Consortium | |
dc.subject | Humans | |
dc.subject | Prostatic Neoplasms | |
dc.subject | Neoplasm Invasiveness | |
dc.subject | Multivariate Analysis | |
dc.subject | Multifactorial Inheritance | |
dc.subject | Aged | |
dc.subject | Middle Aged | |
dc.subject | Ethnic Groups | |
dc.subject | Male | |
dc.subject | Self Report | |
dc.title | Polygenic hazard score is associated with prostate cancer in multi-ethnic populations. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2021-01-12 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1038/s41467-021-21287-0 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2021-02-23 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nature communications | |
pubs.issue | 1 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.publication-status | Published | |
pubs.volume | 12 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Oncogenetics | |
icr.researchteam | Oncogenetics | |
dc.contributor.icrauthor | Eeles, Rosalind | |
dc.contributor.icrauthor | Kote-Jarai, Zsofia | |