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dc.contributor.authorHuynh-Le, M-P
dc.contributor.authorFan, CC
dc.contributor.authorKarunamuni, R
dc.contributor.authorThompson, WK
dc.contributor.authorMartinez, ME
dc.contributor.authorEeles, RA
dc.contributor.authorKote-Jarai, Z
dc.contributor.authorMuir, K
dc.contributor.authorSchleutker, J
dc.contributor.authorPashayan, N
dc.contributor.authorBatra, J
dc.contributor.authorGrönberg, H
dc.contributor.authorNeal, DE
dc.contributor.authorDonovan, JL
dc.contributor.authorHamdy, FC
dc.contributor.authorMartin, RM
dc.contributor.authorNielsen, SF
dc.contributor.authorNordestgaard, BG
dc.contributor.authorWiklund, F
dc.contributor.authorTangen, CM
dc.contributor.authorGiles, GG
dc.contributor.authorWolk, A
dc.contributor.authorAlbanes, D
dc.contributor.authorTravis, RC
dc.contributor.authorBlot, WJ
dc.contributor.authorZheng, W
dc.contributor.authorSanderson, M
dc.contributor.authorStanford, JL
dc.contributor.authorMucci, LA
dc.contributor.authorWest, CML
dc.contributor.authorKibel, AS
dc.contributor.authorCussenot, O
dc.contributor.authorBerndt, SI
dc.contributor.authorKoutros, S
dc.contributor.authorSørensen, KD
dc.contributor.authorCybulski, C
dc.contributor.authorGrindedal, EM
dc.contributor.authorMenegaux, F
dc.contributor.authorKhaw, K-T
dc.contributor.authorPark, JY
dc.contributor.authorIngles, SA
dc.contributor.authorMaier, C
dc.contributor.authorHamilton, RJ
dc.contributor.authorThibodeau, SN
dc.contributor.authorRosenstein, BS
dc.contributor.authorLu, Y-J
dc.contributor.authorWatya, S
dc.contributor.authorVega, A
dc.contributor.authorKogevinas, M
dc.contributor.authorPenney, KL
dc.contributor.authorHuff, C
dc.contributor.authorTeixeira, MR
dc.contributor.authorMultigner, L
dc.contributor.authorLeach, RJ
dc.contributor.authorCannon-Albright, L
dc.contributor.authorBrenner, H
dc.contributor.authorJohn, EM
dc.contributor.authorKaneva, R
dc.contributor.authorLogothetis, CJ
dc.contributor.authorNeuhausen, SL
dc.contributor.authorDe Ruyck, K
dc.contributor.authorPandha, H
dc.contributor.authorRazack, A
dc.contributor.authorNewcomb, LF
dc.contributor.authorFowke, JH
dc.contributor.authorGamulin, M
dc.contributor.authorUsmani, N
dc.contributor.authorClaessens, F
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorTownsend, PA
dc.contributor.authorBush, WS
dc.contributor.authorRoobol, MJ
dc.contributor.authorParent, M-É
dc.contributor.authorHu, JJ
dc.contributor.authorMills, IG
dc.contributor.authorAndreassen, OA
dc.contributor.authorDale, AM
dc.contributor.authorSeibert, TM
dc.contributor.authorUKGPCS collaborators
dc.contributor.authorAPCB (Australian Prostate Cancer BioResource)
dc.contributor.authorNC-LA PCaP Investigators
dc.contributor.authorIMPACT Study Steering Committee and Collaborators
dc.contributor.authorCanary PASS Investigators
dc.contributor.authorProfile Study Steering Committee
dc.contributor.authorPRACTICAL Consortium
dc.date.accessioned2021-03-31T14:07:59Z
dc.date.available2021-03-31T14:07:59Z
dc.date.issued2021-02-23
dc.identifier.citationNature communications, 2021, 12 (1), pp. 1236 - ?en_US
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4484
dc.identifier.eissn2041-1723en_US
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/s41467-021-21287-0en_US
dc.identifier.doi10.1038/s41467-021-21287-0
dc.description.abstractGenetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS<sub>1</sub>) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS<sub>2</sub> (PHS<sub>1</sub>, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS<sub>2</sub> is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p < 10<sup>-180</sup>). Comparing the 80<sup>th</sup>/20<sup>th</sup> PHS<sub>2</sub> percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS<sub>2</sub> risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset.en_US
dc.formatElectronicen_US
dc.format.extent1236 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectUKGPCS collaboratorsen_US
dc.subjectAPCB (Australian Prostate Cancer BioResource)en_US
dc.subjectNC-LA PCaP Investigatorsen_US
dc.subjectIMPACT Study Steering Committee and Collaboratorsen_US
dc.subjectCanary PASS Investigatorsen_US
dc.subjectProfile Study Steering Committeeen_US
dc.subjectPRACTICAL Consortiumen_US
dc.subjectHumansen_US
dc.subjectProstatic Neoplasmsen_US
dc.subjectNeoplasm Invasivenessen_US
dc.subjectMultivariate Analysisen_US
dc.subjectMultifactorial Inheritanceen_US
dc.subjectAgeden_US
dc.subjectMiddle Ageden_US
dc.subjectEthnic Groupsen_US
dc.subjectMaleen_US
dc.subjectSelf Reporten_US
dc.titlePolygenic hazard score is associated with prostate cancer in multi-ethnic populations.en_US
dc.typeJournal Article
dcterms.dateAccepted2021-01-12
rioxxterms.versionVoRen_US
rioxxterms.versionofrecord10.1038/s41467-021-21287-0en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2021-02-23
dc.relation.isPartOfNature communicationsen_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublisheden_US
pubs.volume12en_US
pubs.embargo.termsNot knownen_US
icr.researchteamOncogenetics
dc.contributor.icrauthorKote-Jarai, Zsofiaen_US
dc.contributor.icrauthorEeles, Rosalinden_US


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