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dc.contributor.authorHuynh-Le, M-P
dc.contributor.authorFan, CC
dc.contributor.authorKarunamuni, R
dc.contributor.authorThompson, WK
dc.contributor.authorMartinez, ME
dc.contributor.authorEeles, RA
dc.contributor.authorKote-Jarai, Z
dc.contributor.authorMuir, K
dc.contributor.authorSchleutker, J
dc.contributor.authorPashayan, N
dc.contributor.authorBatra, J
dc.contributor.authorGrönberg, H
dc.contributor.authorNeal, DE
dc.contributor.authorDonovan, JL
dc.contributor.authorHamdy, FC
dc.contributor.authorMartin, RM
dc.contributor.authorNielsen, SF
dc.contributor.authorNordestgaard, BG
dc.contributor.authorWiklund, F
dc.contributor.authorTangen, CM
dc.contributor.authorGiles, GG
dc.contributor.authorWolk, A
dc.contributor.authorAlbanes, D
dc.contributor.authorTravis, RC
dc.contributor.authorBlot, WJ
dc.contributor.authorZheng, W
dc.contributor.authorSanderson, M
dc.contributor.authorStanford, JL
dc.contributor.authorMucci, LA
dc.contributor.authorWest, CML
dc.contributor.authorKibel, AS
dc.contributor.authorCussenot, O
dc.contributor.authorBerndt, SI
dc.contributor.authorKoutros, S
dc.contributor.authorSørensen, KD
dc.contributor.authorCybulski, C
dc.contributor.authorGrindedal, EM
dc.contributor.authorMenegaux, F
dc.contributor.authorKhaw, K-T
dc.contributor.authorPark, JY
dc.contributor.authorIngles, SA
dc.contributor.authorMaier, C
dc.contributor.authorHamilton, RJ
dc.contributor.authorThibodeau, SN
dc.contributor.authorRosenstein, BS
dc.contributor.authorLu, Y-J
dc.contributor.authorWatya, S
dc.contributor.authorVega, A
dc.contributor.authorKogevinas, M
dc.contributor.authorPenney, KL
dc.contributor.authorHuff, C
dc.contributor.authorTeixeira, MR
dc.contributor.authorMultigner, L
dc.contributor.authorLeach, RJ
dc.contributor.authorCannon-Albright, L
dc.contributor.authorBrenner, H
dc.contributor.authorJohn, EM
dc.contributor.authorKaneva, R
dc.contributor.authorLogothetis, CJ
dc.contributor.authorNeuhausen, SL
dc.contributor.authorDe Ruyck, K
dc.contributor.authorPandha, H
dc.contributor.authorRazack, A
dc.contributor.authorNewcomb, LF
dc.contributor.authorFowke, JH
dc.contributor.authorGamulin, M
dc.contributor.authorUsmani, N
dc.contributor.authorClaessens, F
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorTownsend, PA
dc.contributor.authorBush, WS
dc.contributor.authorRoobol, MJ
dc.contributor.authorParent, M-É
dc.contributor.authorHu, JJ
dc.contributor.authorMills, IG
dc.contributor.authorAndreassen, OA
dc.contributor.authorDale, AM
dc.contributor.authorSeibert, TM
dc.contributor.authorUKGPCS collaborators
dc.contributor.authorAPCB (Australian Prostate Cancer BioResource)
dc.contributor.authorNC-LA PCaP Investigators
dc.contributor.authorIMPACT Study Steering Committee and Collaborators
dc.contributor.authorCanary PASS Investigators
dc.contributor.authorProfile Study Steering Committee
dc.contributor.authorPRACTICAL Consortium
dc.date.accessioned2021-03-31T14:07:59Z
dc.date.available2021-03-31T14:07:59Z
dc.date.issued2021-02-23
dc.identifier.citationNature communications, 2021, 12 (1), pp. 1236 - ?
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4484
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/s41467-021-21287-0
dc.description.abstractGenetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS 1 ) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS 2 (PHS 1 , adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS 2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p < 10 -180 ). Comparing the 80 th /20 th PHS 2 percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS 2 risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset.
dc.formatElectronic
dc.format.extent1236 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectUKGPCS collaborators
dc.subjectAPCB (Australian Prostate Cancer BioResource)
dc.subjectNC-LA PCaP Investigators
dc.subjectIMPACT Study Steering Committee and Collaborators
dc.subjectCanary PASS Investigators
dc.subjectProfile Study Steering Committee
dc.subjectPRACTICAL Consortium
dc.subjectHumans
dc.subjectProstatic Neoplasms
dc.subjectNeoplasm Invasiveness
dc.subjectMultivariate Analysis
dc.subjectMultifactorial Inheritance
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectEthnic Groups
dc.subjectMale
dc.subjectSelf Report
dc.titlePolygenic hazard score is associated with prostate cancer in multi-ethnic populations.
dc.typeJournal Article
dcterms.dateAccepted2021-01-12
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41467-021-21287-0
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2021-02-23
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature communications
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublished
pubs.volume12
pubs.embargo.termsNot known
icr.researchteamOncogenetics
icr.researchteamOncogeneticsen_US
dc.contributor.icrauthorKote-Jarai, Zsofiaen
dc.contributor.icrauthorEeles, Rosalinden


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