Show simple item record

SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay

dc.contributor.authorBuck, MD
dc.contributor.authorPoirier, EZ
dc.contributor.authorCardoso, A
dc.contributor.authorFrederico, B
dc.contributor.authorCanton, J
dc.contributor.authorBarrell, S
dc.contributor.authorBeale, R
dc.contributor.authorByrne, R
dc.contributor.authorCaidan, S
dc.contributor.authorCrawford, M
dc.contributor.authorCubitt, L
dc.contributor.authorGandhi, S
dc.contributor.authorGoldstone, R
dc.contributor.authorGrant, PR
dc.contributor.authorGulati, K
dc.contributor.authorHindmarsh, S
dc.contributor.authorHowell, M
dc.contributor.authorHubank, M
dc.contributor.authorInstrell, R
dc.contributor.authorJiang, M
dc.contributor.authorKassiotis, G
dc.contributor.authorLu, W-T
dc.contributor.authorMacRae, JI
dc.contributor.authorMartini, I
dc.contributor.authorMiller, D
dc.contributor.authorMoore, D
dc.contributor.authorNastouli, E
dc.contributor.authorNicod, J
dc.contributor.authorNightingale, L
dc.contributor.authorOlsen, J
dc.contributor.authorOomatia, A
dc.contributor.authorO'Reilly, N
dc.contributor.authorRideg, A
dc.contributor.authorSong, O-R
dc.contributor.authorStrange, A
dc.contributor.authorSwanton, C
dc.contributor.authorTurajlic, S
dc.contributor.authorWu, M
dc.contributor.authorReis e Sousa, C
dc.date.accessioned2021-04-09T14:10:50Z
dc.date.available2021-04-09T14:10:50Z
dc.date.issued2021-01-21
dc.identifier.citationWellcome Open Research, 6 pp. 9 - 9
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4513
dc.identifier.eissn2398-502X
dc.identifier.doi10.12688/wellcomeopenres.16517.1
dc.description.abstractThe ongoing pandemic of SARS-CoV-2 calls for rapid and cost-effective methods to accurately identify infected individuals. The vast majority of patient samples is assessed for viral RNA presence by RT-qPCR. Our biomedical research institute, in collaboration between partner hospitals and an accredited clinical diagnostic laboratory, established a diagnostic testing pipeline that has reported on more than 252,000 RT-qPCR results since its commencement at the beginning of April 2020. However, due to ongoing demand and competition for critical resources, alternative testing strategies were sought. In this work, we present a clinically-validated procedure for high-throughput SARS-CoV-2 detection by RT-LAMP in 25 minutes that is robust, reliable, repeatable, sensitive, specific, and inexpensive.</ns3:p>
dc.format.extent9 - 9
dc.languageeng
dc.language.isoeng
dc.publisherF1000 Research Ltd
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleSARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay
dc.typeJournal Article
dcterms.dateAccepted2021-01-21
rioxxterms.versionVoR
rioxxterms.versionofrecord10.12688/wellcomeopenres.16517.1
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfWellcome Open Research
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR
pubs.publication-statusPublished online
pubs.volume6
pubs.embargo.termsNot known
dc.contributor.icrauthorTurajlic, Samra


Files in this item

Thumbnail
Name:
bf0e2d25-be09-4c12-8adf-239db1 ...
Size:
4.384Mb
Format:
PDF
Description:
Published version
View/Open

This item appears in the following collection(s)

Show simple item record

https://creativecommons.org/licenses/by/4.0
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0