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dc.contributor.authorPiovesan, D
dc.contributor.authorNecci, M
dc.contributor.authorEscobedo, N
dc.contributor.authorMonzon, AM
dc.contributor.authorHatos, A
dc.contributor.authorMičetić, I
dc.contributor.authorQuaglia, F
dc.contributor.authorPaladin, L
dc.contributor.authorRamasamy, P
dc.contributor.authorDosztányi, Z
dc.contributor.authorVranken, WF
dc.contributor.authorDavey, NE
dc.contributor.authorParisi, G
dc.contributor.authorFuxreiter, M
dc.contributor.authorTosatto, SCE
dc.date.accessioned2021-04-13T15:13:07Z
dc.date.available2021-04-13T15:13:07Z
dc.date.issued2021-01-08
dc.identifier.citationNucleic acids research, 2021, 49 (D1), pp. D361 - D367
dc.identifier.issn0305-1048
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4521
dc.identifier.eissn1362-4962
dc.identifier.doi10.1093/nar/gkaa1058
dc.description.abstractThe MobiDB database (URL: https://mobidb.org/) provides predictions and annotations for intrinsically disordered proteins. Here, we report recent developments implemented in MobiDB version 4, regarding the database format, with novel types of annotations and an improved update process. The new website includes a re-designed user interface, a more effective search engine and advanced API for programmatic access. The new database schema gives more flexibility for the users, as well as simplifying the maintenance and updates. In addition, the new entry page provides more visualisation tools including customizable feature viewer and graphs of the residue contact maps. MobiDB v4 annotates the binding modes of disordered proteins, whether they undergo disorder-to-order transitions or remain disordered in the bound state. In addition, disordered regions undergoing liquid-liquid phase separation or post-translational modifications are defined. The integrated information is presented in a simplified interface, which enables faster searches and allows large customized datasets to be downloaded in TSV, Fasta or JSON formats. An alternative advanced interface allows users to drill deeper into features of interest. A new statistics page provides information at database and proteome levels. The new MobiDB version presents state-of-the-art knowledge on disordered proteins and improves data accessibility for both computational and experimental users.
dc.formatPrint
dc.format.extentD361 - D367
dc.languageeng
dc.language.isoeng
dc.publisherOXFORD UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectProtein Processing, Post-Translational
dc.subjectAlgorithms
dc.subjectInternet
dc.subjectSoftware
dc.subjectDatabases, Protein
dc.subjectMolecular Sequence Annotation
dc.subjectIntrinsically Disordered Proteins
dc.titleMobiDB: intrinsically disordered proteins in 2021.
dc.typeJournal Article
dcterms.dateAccepted2020-11-19
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1093/nar/gkaa1058
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNucleic acids research
pubs.issueD1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR
pubs.publication-statusPublished
pubs.volume49
pubs.embargo.termsNot known
dc.contributor.icrauthorDavey, Norman


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