dc.contributor.author | Harrod, A | |
dc.contributor.author | Lane, KA | |
dc.contributor.author | Downs, JA | |
dc.date.accessioned | 2021-04-21T10:51:06Z | |
dc.date.available | 2021-04-21T10:51:06Z | |
dc.date.issued | 2020-09-01 | |
dc.identifier.citation | DNA repair, 2020, 93 pp. 102919 - ? | |
dc.identifier.issn | 1568-7864 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4535 | |
dc.identifier.eissn | 1568-7856 | |
dc.identifier.doi | 10.1016/j.dnarep.2020.102919 | |
dc.description.abstract | Mammalian cells possess multiple closely related SWI/SNF chromatin remodelling complexes. These complexes have been implicated in the cellular response to DNA double strand breaks (DSBs). Evidence suggests that SWI/SNF complexes contribute to successful repair via both the homologous recombination and non-homologous end joining pathways. In addition, repressing transcription near DSBs is dependent on SWI/SNF activity. Understanding these roles is important because SWI/SNF complexes are frequently dysregulated in cancer, and DNA DSB repair defects have the potential to be therapeutically exploited. In this graphical review, we summarise what is known about SWI/SNF contribution to DNA DSB responses in mammalian cells and provide an overview of the SWI/SNF-encoding gene alteration spectrum in human cancers. | |
dc.format | Print | |
dc.format.extent | 102919 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.subject | Animals | |
dc.subject | Mammals | |
dc.subject | Humans | |
dc.subject | DNA Helicases | |
dc.subject | DNA-Binding Proteins | |
dc.subject | Nuclear Proteins | |
dc.subject | Chromosomal Proteins, Non-Histone | |
dc.subject | Transcription Factors | |
dc.subject | DNA | |
dc.subject | Chromatin Assembly and Disassembly | |
dc.subject | DNA Breaks, Double-Stranded | |
dc.subject | DNA End-Joining Repair | |
dc.subject | Recombinational DNA Repair | |
dc.title | The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2020-06-22 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1016/j.dnarep.2020.102919 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | DNA repair | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Epigenetics and Genome Stability | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Epigenetics and Genome Stability | |
pubs.publication-status | Published | |
pubs.volume | 93 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Epigenetics and Genome Stability | |
icr.researchteam | Epigenetics and Genome Stability | |
dc.contributor.icrauthor | Downs, Jessica | |