The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks.
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Date
2020-09-01ICR Author
Author
Harrod, A
Lane, KA
Downs, JA
Type
Journal Article
Metadata
Show full item recordAbstract
Mammalian cells possess multiple closely related SWI/SNF chromatin remodelling complexes. These complexes have been implicated in the cellular response to DNA double strand breaks (DSBs). Evidence suggests that SWI/SNF complexes contribute to successful repair via both the homologous recombination and non-homologous end joining pathways. In addition, repressing transcription near DSBs is dependent on SWI/SNF activity. Understanding these roles is important because SWI/SNF complexes are frequently dysregulated in cancer, and DNA DSB repair defects have the potential to be therapeutically exploited. In this graphical review, we summarise what is known about SWI/SNF contribution to DNA DSB responses in mammalian cells and provide an overview of the SWI/SNF-encoding gene alteration spectrum in human cancers.
Collections
Subject
Animals
Mammals
Humans
DNA Helicases
DNA-Binding Proteins
Nuclear Proteins
Chromosomal Proteins, Non-Histone
Transcription Factors
DNA
Chromatin Assembly and Disassembly
DNA Breaks, Double-Stranded
DNA End-Joining Repair
Recombinational DNA Repair
Research team
Epigenetics and Genome Stability
Epigenetics and Genome Stability
Language
eng
Date accepted
2020-06-22
Citation
DNA repair, 2020, 93 pp. 102919 - ?
Publisher
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