The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks.
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Mammalian cells possess multiple closely related SWI/SNF chromatin remodelling complexes. These complexes have been implicated in the cellular response to DNA double strand breaks (DSBs). Evidence suggests that SWI/SNF complexes contribute to successful repair via both the homologous recombination and non-homologous end joining pathways. In addition, repressing transcription near DSBs is dependent on SWI/SNF activity. Understanding these roles is important because SWI/SNF complexes are frequently dysregulated in cancer, and DNA DSB repair defects have the potential to be therapeutically exploited. In this graphical review, we summarise what is known about SWI/SNF contribution to DNA DSB responses in mammalian cells and provide an overview of the SWI/SNF-encoding gene alteration spectrum in human cancers.
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Chromosomal Proteins, Non-Histone
Chromatin Assembly and Disassembly
DNA Breaks, Double-Stranded
DNA End-Joining Repair
Recombinational DNA Repair
Epigenetics and Genome Stability
DNA repair, 2020, 93 pp. 102919 - ?