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dc.contributor.authorDumas, L
dc.contributor.authorBowen, R
dc.contributor.authorButler, J
dc.contributor.authorBanerjee, S
dc.date.accessioned2021-05-25T13:46:24Z
dc.date.available2021-05-25T13:46:24Z
dc.date.issued2021-02-25
dc.identifier.citationCancers, 2021, 13 (5)
dc.identifier.issn2072-6694
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4586
dc.identifier.eissn2072-6694
dc.identifier.eissn2072-6694en_US
dc.identifier.doi10.3390/cancers13050952
dc.identifier.doi10.3390/cancers13050952en_US
dc.description.abstractOlder women with ovarian cancer have disproportionately poorer survival outcomes than their younger counterparts and receive less treatment. In order to understand where the gaps lie in the treatment of older patients, studies incorporating more detailed assessment of baseline characteristics and treatment delivery beyond the scope of most cancer registries are required. We aimed to assess the proportion of women over the age of 65 who are offered and receive standard of care for first-line ovarian cancer at two UK NHS Cancer Centres over a 5-year period (December 2009 to August 2015). Standard of care treatment was defined as a combination of cytoreductive surgery and if indicated platinum-based chemotherapy (combination or single-agent). Sixty-five percent of patients aged 65 and above received standard of care treatment. Increasing age was associated with lower rates of receiving standard of care (35% > 80 years old versus 78% of 65-69-year-olds, <i>p</i> = 0.000). Older women were less likely to complete the planned chemotherapy course (<i>p</i> = 0.034). The oldest women continue to receive lower rates of standard care compared to younger women. Once adjusted for Federation of Gynaecology and Obstetrics (FIGO) stage, Eastern Cooperative Oncology Group (ECOG) performance status and first-line treatment received, age was no longer an independent risk factor for poorer overall survival. Optimisation of vulnerable patients utilising a comprehensive geriatric assessment and directed interventions to facilitate the delivery of standard of care treatment could help narrow the survival discrepancy between the oldest patients and their younger counterparts.
dc.formatElectronic
dc.languageeng
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleUnder-Treatment of Older Patients with Newly Diagnosed Epithelial Ovarian Cancer Remains an Issue.
dc.typeJournal Article
dcterms.dateAccepted2021-02-18
rioxxterms.versionVoR
rioxxterms.versionofrecord10.3390/cancers13050952
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2021-02-25
rioxxterms.licenseref.startdate2021-02-25en_US
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCancers
pubs.issue5
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume13en_US
pubs.embargo.termsNot known
dc.contributor.icrauthorBanerjee, Susanaen


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