dc.contributor.author | Worboys, JD | |
dc.contributor.author | Sinclair, J | |
dc.contributor.author | Yuan, Y | |
dc.contributor.author | Jørgensen, C | |
dc.date.accessioned | 2017-03-01T16:44:53Z | |
dc.date.issued | 2014-10-01 | |
dc.identifier.citation | Nature methods, 2014, 11 (10), pp. 1041 - 1044 | |
dc.identifier.issn | 1548-7091 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/459 | |
dc.identifier.eissn | 1548-7105 | |
dc.identifier.doi | 10.1038/nmeth.3072 | |
dc.description.abstract | In targeted proteomics it is critical that peptides are not only proteotypic but also accurately represent the level of the protein (quantotypic). Numerous approaches are used to identify proteotypic peptides, but quantotypic properties are rarely assessed. We show that measuring ratios of proteotypic peptides across biological samples can be used to empirically identify peptides with good quantotypic properties. We applied this technique to identify quantotypic peptides for 21% of the human kinome. | |
dc.format | Print-Electronic | |
dc.format.extent | 1041 - 1044 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights.uri | https://www.rioxx.net/licenses/all-rights-reserved | |
dc.subject | Cell Line, Tumor | |
dc.subject | Humans | |
dc.subject | Protein Kinases | |
dc.subject | Peptides | |
dc.subject | Proteins | |
dc.subject | Proteome | |
dc.subject | Chromatography | |
dc.subject | Proteomics | |
dc.subject | Computational Biology | |
dc.subject | Gene Expression Regulation, Neoplastic | |
dc.subject | Algorithms | |
dc.title | Systematic evaluation of quantotypic peptides for targeted analysis of the human kinome. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2014-07-14 | |
rioxxterms.versionofrecord | 10.1038/nmeth.3072 | |
rioxxterms.licenseref.uri | https://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2014-10 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nature methods | |
pubs.issue | 10 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Cell Communication | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Computational Pathology & Integrated Genomics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Cell Communication | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Computational Pathology & Integrated Genomics | |
pubs.publication-status | Published | |
pubs.volume | 11 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Cell Communication | |
icr.researchteam | Computational Pathology & Integrated Genomics | |
dc.contributor.icrauthor | Worboys, Jonathan David | |
dc.contributor.icrauthor | Yuan, Yinyin | |