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dc.contributor.authorWorboys, JDen_US
dc.contributor.authorSinclair, Jen_US
dc.contributor.authorYuan, Yen_US
dc.contributor.authorJørgensen, Cen_US
dc.date.accessioned2017-03-01T16:44:53Z
dc.date.issued2014-10en_US
dc.identifier.citationNature methods, 2014, 11 (10), pp. 1041 - 1044en_US
dc.identifier.issn1548-7091en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/459
dc.identifier.eissn1548-7105en_US
dc.identifier.doi10.1038/nmeth.3072en_US
dc.description.abstractIn targeted proteomics it is critical that peptides are not only proteotypic but also accurately represent the level of the protein (quantotypic). Numerous approaches are used to identify proteotypic peptides, but quantotypic properties are rarely assessed. We show that measuring ratios of proteotypic peptides across biological samples can be used to empirically identify peptides with good quantotypic properties. We applied this technique to identify quantotypic peptides for 21% of the human kinome.en_US
dc.formatPrint-Electronicen_US
dc.format.extent1041 - 1044en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
dc.subjectCell Line, Tumoren_US
dc.subjectHumansen_US
dc.subjectProtein Kinasesen_US
dc.subjectPeptidesen_US
dc.subjectProteinsen_US
dc.subjectProteomeen_US
dc.subjectChromatographyen_US
dc.subjectProteomicsen_US
dc.subjectComputational Biologyen_US
dc.subjectGene Expression Regulation, Neoplasticen_US
dc.subjectAlgorithmsen_US
dc.titleSystematic evaluation of quantotypic peptides for targeted analysis of the human kinome.en_US
dc.typeJournal Article
dcterms.dateAccepted2014-07-14en_US
rioxxterms.versionofrecord10.1038/nmeth.3072en_US
rioxxterms.licenseref.startdate2014-10en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfNature methodsen_US
pubs.issue10en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Cell Communication
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Computational Pathology & Integrated Genomics
pubs.publication-statusPublisheden_US
pubs.volume11en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamCell Communicationen_US
icr.researchteamComputational Pathology & Integrated Genomicsen_US
dc.contributor.icrauthorYuan, Yinyinen_US
dc.contributor.icrauthorWorboys, Jonathan Daviden_US
dc.contributor.icrauthorJorgensen, Clausen_US


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