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dc.contributor.authorLin, H-Y
dc.contributor.authorWang, X
dc.contributor.authorTseng, T-S
dc.contributor.authorKao, Y-H
dc.contributor.authorFang, Z
dc.contributor.authorMolina, PE
dc.contributor.authorCheng, C-H
dc.contributor.authorBerglund, AE
dc.contributor.authorEeles, RA
dc.contributor.authorMuir, KR
dc.contributor.authorPashayan, N
dc.contributor.authorHaiman, CA
dc.contributor.authorBrenner, H
dc.contributor.authorConsortium, TP
dc.contributor.authorPark, JY
dc.date.accessioned2021-06-10T15:22:53Z
dc.date.available2021-06-10T15:22:53Z
dc.date.issued2021-02-02
dc.identifier.citationJournal of clinical medicine, 2021, 10 (3)en_US
dc.identifier.issn2077-0383
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4607
dc.identifier.eissn2077-0383en_US
dc.identifier.eissn2077-0383
dc.identifier.doi10.3390/jcm10030553en_US
dc.identifier.doi10.3390/jcm10030553
dc.description.abstractExcessive alcohol intake is a well-known modifiable risk factor for many cancers. It is still unclear whether genetic variants or single nucleotide polymorphisms (SNPs) can modify alcohol intake's impact on prostate cancer (PCa) aggressiveness. The objective is to test the alcohol-SNP interactions of the 7501 SNPs in the four pathways (angiogenesis, mitochondria, miRNA, and androgen metabolism-related pathways) associated with PCa aggressiveness. We evaluated the impacts of three excessive alcohol intake behaviors in 3306 PCa patients with European ancestry from the PCa Consortium. We tested the alcohol-SNP interactions using logistic models with the discovery-validation study design. All three excessive alcohol intake behaviors were not significantly associated with PCa aggressiveness. However, the interactions of excessive alcohol intake and three SNPs (rs13107662 [<i>CAMK2D</i>, <i>p</i> = 6.2 × 10<sup>-6</sup>], rs9907521 [<i>PRKCA,</i> <i>p</i> = 7.1 × 10<sup>-5</sup>], and rs11925452 [<i>ROBO1,</i> <i>p</i> = 8.2 × 10<sup>-4</sup>]) were significantly associated with PCa aggressiveness. These alcohol-SNP interactions revealed contrasting effects of excessive alcohol intake on PCa aggressiveness according to the genotypes in the identified SNPs. We identified PCa patients with the rs13107662 (<i>CAMK2D</i>) AA genotype, the rs11925452 (<i>ROBO1</i>) AA genotype, and the rs9907521 (<i>PRKCA)</i> AG genotype were more vulnerable to excessive alcohol intake for developing aggressive PCa. Our findings support that the impact of excessive alcohol intake on PCa aggressiveness was varied by the selected genetic profiles.en_US
dc.formatElectronicen_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleAlcohol Intake and Alcohol-SNP Interactions Associated with Prostate Cancer Aggressiveness.en_US
dc.typeJournal Article
dcterms.dateAccepted2021-01-28
rioxxterms.versionVoRen_US
rioxxterms.versionofrecord10.3390/jcm10030553en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2021-02-02
dc.relation.isPartOfJournal of clinical medicineen_US
pubs.issue3en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublisheden_US
pubs.volume10en_US
pubs.embargo.termsNot knownen_US
icr.researchteamOncogenetics
dc.contributor.icrauthorEeles, Rosalinden_US


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