Show simple item record

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.

dc.contributor.authorConti, DV
dc.contributor.authorDarst, BF
dc.contributor.authorMoss, LC
dc.contributor.authorSaunders, EJ
dc.contributor.authorSheng, X
dc.contributor.authorChou, A
dc.contributor.authorSchumacher, FR
dc.contributor.authorOlama, AAA
dc.contributor.authorBenlloch, S
dc.contributor.authorDadaev, T
dc.contributor.authorBrook, MN
dc.contributor.authorSahimi, A
dc.contributor.authorHoffmann, TJ
dc.contributor.authorTakahashi, A
dc.contributor.authorMatsuda, K
dc.contributor.authorMomozawa, Y
dc.contributor.authorFujita, M
dc.contributor.authorMuir, K
dc.contributor.authorLophatananon, A
dc.contributor.authorWan, P
dc.contributor.authorLe Marchand, L
dc.contributor.authorWilkens, LR
dc.contributor.authorStevens, VL
dc.contributor.authorGapstur, SM
dc.contributor.authorCarter, BD
dc.contributor.authorSchleutker, J
dc.contributor.authorTammela, TLJ
dc.contributor.authorSipeky, C
dc.contributor.authorAuvinen, A
dc.contributor.authorGiles, GG
dc.contributor.authorSouthey, MC
dc.contributor.authorMacInnis, RJ
dc.contributor.authorCybulski, C
dc.contributor.authorWokołorczyk, D
dc.contributor.authorLubiński, J
dc.contributor.authorNeal, DE
dc.contributor.authorDonovan, JL
dc.contributor.authorHamdy, FC
dc.contributor.authorMartin, RM
dc.contributor.authorNordestgaard, BG
dc.contributor.authorNielsen, SF
dc.contributor.authorWeischer, M
dc.contributor.authorBojesen, SE
dc.contributor.authorRøder, MA
dc.contributor.authorIversen, P
dc.contributor.authorBatra, J
dc.contributor.authorChambers, S
dc.contributor.authorMoya, L
dc.contributor.authorHorvath, L
dc.contributor.authorClements, JA
dc.contributor.authorTilley, W
dc.contributor.authorRisbridger, GP
dc.contributor.authorGronberg, H
dc.contributor.authorAly, M
dc.contributor.authorSzulkin, R
dc.contributor.authorEklund, M
dc.contributor.authorNordström, T
dc.contributor.authorPashayan, N
dc.contributor.authorDunning, AM
dc.contributor.authorGhoussaini, M
dc.contributor.authorTravis, RC
dc.contributor.authorKey, TJ
dc.contributor.authorRiboli, E
dc.contributor.authorPark, JY
dc.contributor.authorSellers, TA
dc.contributor.authorLin, H-Y
dc.contributor.authorAlbanes, D
dc.contributor.authorWeinstein, SJ
dc.contributor.authorMucci, LA
dc.contributor.authorGiovannucci, E
dc.contributor.authorLindstrom, S
dc.contributor.authorKraft, P
dc.contributor.authorHunter, DJ
dc.contributor.authorPenney, KL
dc.contributor.authorTurman, C
dc.contributor.authorTangen, CM
dc.contributor.authorGoodman, PJ
dc.contributor.authorThompson, IM
dc.contributor.authorHamilton, RJ
dc.contributor.authorFleshner, NE
dc.contributor.authorFinelli, A
dc.contributor.authorParent, M-É
dc.contributor.authorStanford, JL
dc.contributor.authorOstrander, EA
dc.contributor.authorGeybels, MS
dc.contributor.authorKoutros, S
dc.contributor.authorFreeman, LEB
dc.contributor.authorStampfer, M
dc.contributor.authorWolk, A
dc.contributor.authorHåkansson, N
dc.contributor.authorAndriole, GL
dc.contributor.authorHoover, RN
dc.contributor.authorMachiela, MJ
dc.contributor.authorSørensen, KD
dc.contributor.authorBorre, M
dc.contributor.authorBlot, WJ
dc.contributor.authorZheng, W
dc.contributor.authorYeboah, ED
dc.contributor.authorMensah, JE
dc.contributor.authorLu, Y-J
dc.contributor.authorZhang, H-W
dc.contributor.authorFeng, N
dc.contributor.authorMao, X
dc.contributor.authorWu, Y
dc.contributor.authorZhao, S-C
dc.contributor.authorSun, Z
dc.contributor.authorThibodeau, SN
dc.contributor.authorMcDonnell, SK
dc.contributor.authorSchaid, DJ
dc.contributor.authorWest, CML
dc.contributor.authorBurnet, N
dc.contributor.authorBarnett, G
dc.contributor.authorMaier, C
dc.contributor.authorSchnoeller, T
dc.contributor.authorLuedeke, M
dc.contributor.authorKibel, AS
dc.contributor.authorDrake, BF
dc.contributor.authorCussenot, O
dc.contributor.authorCancel-Tassin, G
dc.contributor.authorMenegaux, F
dc.contributor.authorTruong, T
dc.contributor.authorKoudou, YA
dc.contributor.authorJohn, EM
dc.contributor.authorGrindedal, EM
dc.contributor.authorMaehle, L
dc.contributor.authorKhaw, K-T
dc.contributor.authorIngles, SA
dc.contributor.authorStern, MC
dc.contributor.authorVega, A
dc.contributor.authorGómez-Caamaño, A
dc.contributor.authorFachal, L
dc.contributor.authorRosenstein, BS
dc.contributor.authorKerns, SL
dc.contributor.authorOstrer, H
dc.contributor.authorTeixeira, MR
dc.contributor.authorPaulo, P
dc.contributor.authorBrandão, A
dc.contributor.authorWatya, S
dc.contributor.authorLubwama, A
dc.contributor.authorBensen, JT
dc.contributor.authorFontham, ETH
dc.contributor.authorMohler, J
dc.contributor.authorTaylor, JA
dc.contributor.authorKogevinas, M
dc.contributor.authorLlorca, J
dc.contributor.authorCastaño-Vinyals, G
dc.contributor.authorCannon-Albright, L
dc.contributor.authorTeerlink, CC
dc.contributor.authorHuff, CD
dc.contributor.authorStrom, SS
dc.contributor.authorMultigner, L
dc.contributor.authorBlanchet, P
dc.contributor.authorBrureau, L
dc.contributor.authorKaneva, R
dc.contributor.authorSlavov, C
dc.contributor.authorMitev, V
dc.contributor.authorLeach, RJ
dc.contributor.authorWeaver, B
dc.contributor.authorBrenner, H
dc.contributor.authorCuk, K
dc.contributor.authorHolleczek, B
dc.contributor.authorSaum, K-U
dc.contributor.authorKlein, EA
dc.contributor.authorHsing, AW
dc.contributor.authorKittles, RA
dc.contributor.authorMurphy, AB
dc.contributor.authorLogothetis, CJ
dc.contributor.authorKim, J
dc.contributor.authorNeuhausen, SL
dc.contributor.authorSteele, L
dc.contributor.authorDing, YC
dc.contributor.authorIsaacs, WB
dc.contributor.authorNemesure, B
dc.contributor.authorHennis, AJM
dc.contributor.authorCarpten, J
dc.contributor.authorPandha, H
dc.contributor.authorMichael, A
dc.contributor.authorDe Ruyck, K
dc.contributor.authorDe Meerleer, G
dc.contributor.authorOst, P
dc.contributor.authorXu, J
dc.contributor.authorRazack, A
dc.contributor.authorLim, J
dc.contributor.authorTeo, S-H
dc.contributor.authorNewcomb, LF
dc.contributor.authorLin, DW
dc.contributor.authorFowke, JH
dc.contributor.authorNeslund-Dudas, C
dc.contributor.authorRybicki, BA
dc.contributor.authorGamulin, M
dc.contributor.authorLessel, D
dc.contributor.authorKulis, T
dc.contributor.authorUsmani, N
dc.contributor.authorSinghal, S
dc.contributor.authorParliament, M
dc.contributor.authorClaessens, F
dc.contributor.authorJoniau, S
dc.contributor.authorVan den Broeck, T
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorCastelao, JE
dc.contributor.authorMartinez, ME
dc.contributor.authorLarkin, S
dc.contributor.authorTownsend, PA
dc.contributor.authorAukim-Hastie, C
dc.contributor.authorBush, WS
dc.contributor.authorAldrich, MC
dc.contributor.authorCrawford, DC
dc.contributor.authorSrivastava, S
dc.contributor.authorCullen, JC
dc.contributor.authorPetrovics, G
dc.contributor.authorCasey, G
dc.contributor.authorRoobol, MJ
dc.contributor.authorJenster, G
dc.contributor.authorvan Schaik, RHN
dc.contributor.authorHu, JJ
dc.contributor.authorSanderson, M
dc.contributor.authorVarma, R
dc.contributor.authorMcKean-Cowdin, R
dc.contributor.authorTorres, M
dc.contributor.authorMancuso, N
dc.contributor.authorBerndt, SI
dc.contributor.authorVan Den Eeden, SK
dc.contributor.authorEaston, DF
dc.contributor.authorChanock, SJ
dc.contributor.authorCook, MB
dc.contributor.authorWiklund, F
dc.contributor.authorNakagawa, H
dc.contributor.authorWitte, JS
dc.contributor.authorEeles, RA
dc.contributor.authorKote-Jarai, Z
dc.contributor.authorHaiman, CA
dc.date.accessioned2021-08-19T14:16:35Z
dc.date.available2021-08-19T14:16:35Z
dc.date.issued2021-01-04
dc.identifier.citationNature genetics, 2021, 53 (1), pp. 65 - 75
dc.identifier.issn1061-4036
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4768
dc.identifier.eissn1546-1718
dc.identifier.doi10.1038/s41588-020-00748-0
dc.description.abstractProstate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction.
dc.formatPrint-Electronic
dc.format.extent65 - 75
dc.languageeng
dc.language.isoeng
dc.publisherNATURE PORTFOLIO
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectHumans
dc.subjectProstatic Neoplasms
dc.subjectNeoplasm Invasiveness
dc.subjectGenetic Predisposition to Disease
dc.subjectOdds Ratio
dc.subjectRisk Factors
dc.subjectMiddle Aged
dc.subjectContinental Population Groups
dc.subjectMale
dc.subjectGenome-Wide Association Study
dc.subjectGenetic Loci
dc.subjectMolecular Sequence Annotation
dc.titleTrans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
dc.typeJournal Article
dcterms.dateAccepted2020-11-05
rioxxterms.versionAM
rioxxterms.versionofrecord10.1038/s41588-020-00748-0
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-01-04
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature genetics
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/18/19 Starting Cohort
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/18/19 Starting Cohort
pubs.publication-statusPublished
pubs.volume53
pubs.embargo.termsNot known
icr.researchteamOncogenetics
icr.researchteamOncogenetics
dc.contributor.icrauthorSaunders, Edward
dc.contributor.icrauthorBrook, Mark
dc.contributor.icrauthorEeles, Rosalind
dc.contributor.icrauthorKote-Jarai, Zsofia


Files in this item

Thumbnail
Name:
Trans-ancestry genome-wide ...
Size:
3.778Mb
Format:
PDF
Description:
Published version
View/Open

This item appears in the following collection(s)

Show simple item record