Show simple item record

dc.contributor.authorLaw, PJ
dc.contributor.authorBerndt, SI
dc.contributor.authorSpeedy, HE
dc.contributor.authorCamp, NJ
dc.contributor.authorSava, GP
dc.contributor.authorSkibola, CF
dc.contributor.authorHolroyd, A
dc.contributor.authorJoseph, V
dc.contributor.authorSunter, NJ
dc.contributor.authorNieters, A
dc.contributor.authorBea, S
dc.contributor.authorMonnereau, A
dc.contributor.authorMartin-Garcia, D
dc.contributor.authorGoldin, LR
dc.contributor.authorClot, G
dc.contributor.authorTeras, LR
dc.contributor.authorQuintela, I
dc.contributor.authorBirmann, BM
dc.contributor.authorJayne, S
dc.contributor.authorCozen, W
dc.contributor.authorMajid, A
dc.contributor.authorSmedby, KE
dc.contributor.authorLan, Q
dc.contributor.authorDearden, C
dc.contributor.authorBrooks-Wilson, AR
dc.contributor.authorHall, AG
dc.contributor.authorPurdue, MP
dc.contributor.authorMainou-Fowler, T
dc.contributor.authorVajdic, CM
dc.contributor.authorJackson, GH
dc.contributor.authorCocco, P
dc.contributor.authorMarr, H
dc.contributor.authorZhang, Y
dc.contributor.authorZheng, T
dc.contributor.authorGiles, GG
dc.contributor.authorLawrence, C
dc.contributor.authorCall, TG
dc.contributor.authorLiebow, M
dc.contributor.authorMelbye, M
dc.contributor.authorGlimelius, B
dc.contributor.authorMansouri, L
dc.contributor.authorGlenn, M
dc.contributor.authorCurtin, K
dc.contributor.authorDiver, WR
dc.contributor.authorLink, BK
dc.contributor.authorConde, L
dc.contributor.authorBracci, PM
dc.contributor.authorHolly, EA
dc.contributor.authorJackson, RD
dc.contributor.authorTinker, LF
dc.contributor.authorBenavente, Y
dc.contributor.authorBoffetta, P
dc.contributor.authorBrennan, P
dc.contributor.authorMaynadie, M
dc.contributor.authorMcKay, J
dc.contributor.authorAlbanes, D
dc.contributor.authorWeinstein, S
dc.contributor.authorWang, Z
dc.contributor.authorCaporaso, NE
dc.contributor.authorMorton, LM
dc.contributor.authorSeverson, RK
dc.contributor.authorRiboli, E
dc.contributor.authorVineis, P
dc.contributor.authorVermeulen, RCH
dc.contributor.authorSouthey, MC
dc.contributor.authorMilne, RL
dc.contributor.authorClavel, J
dc.contributor.authorTopka, S
dc.contributor.authorSpinelli, JJ
dc.contributor.authorKraft, P
dc.contributor.authorEnnas, MG
dc.contributor.authorSummerfield, G
dc.contributor.authorFerri, GM
dc.contributor.authorHarris, RJ
dc.contributor.authorMiligi, L
dc.contributor.authorPettitt, AR
dc.contributor.authorNorth, KE
dc.contributor.authorAllsup, DJ
dc.contributor.authorFraumeni, JF
dc.contributor.authorBailey, JR
dc.contributor.authorOffit, K
dc.contributor.authorPratt, G
dc.contributor.authorHjalgrim, H
dc.contributor.authorPepper, C
dc.contributor.authorChanock, SJ
dc.contributor.authorFegan, C
dc.contributor.authorRosenquist, R
dc.contributor.authorde Sanjose, S
dc.contributor.authorCarracedo, A
dc.contributor.authorDyer, MJS
dc.contributor.authorCatovsky, D
dc.contributor.authorCampo, E
dc.contributor.authorCerhan, JR
dc.contributor.authorAllan, JM
dc.contributor.authorRothman, N
dc.contributor.authorHoulston, R
dc.contributor.authorSlager, S
dc.date.accessioned2017-03-06T15:50:39Z
dc.date.issued2017-02-06
dc.identifier.citationNature communications, 2017, 8 pp. 14175 - ?
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/476
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/ncomms14175
dc.description.abstractSeveral chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10 -13 ), 1q42.13 (rs41271473, P=1.06 × 10 -10 ), 4q24 (rs71597109, P=1.37 × 10 -10 ), 4q35.1 (rs57214277, P=3.69 × 10 -8 ), 6p21.31 (rs3800461, P=1.97 × 10 -8 ), 11q23.2 (rs61904987, P=2.64 × 10 -11 ), 18q21.1 (rs1036935, P=3.27 × 10 -8 ), 19p13.3 (rs7254272, P=4.67 × 10 -8 ) and 22q13.33 (rs140522, P=2.70 × 10 -9 ). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response.
dc.formatElectronic
dc.format.extent14175 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectB-Lymphocytes
dc.subjectChromosomes, Human
dc.subjectHumans
dc.subjectGenetic Predisposition to Disease
dc.subjectCase-Control Studies
dc.subjectChromosome Mapping
dc.subjectAntibody Formation
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectLeukemia, Lymphocytic, Chronic, B-Cell
dc.subjectGenome-Wide Association Study
dc.subjectYoung Adult
dc.titleGenome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.
dc.typeJournal Article
dcterms.dateAccepted2016-12-06
rioxxterms.versionofrecord10.1038/ncomms14175
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2017-02-06
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature communications
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume8
pubs.embargo.termsNo embargo
icr.researchteamCancer Genomicsen_US
icr.researchteamMolecular & Population Geneticsen_US
dc.contributor.icrauthorSava, Georginaen
dc.contributor.icrauthorHoulston, Richarden
dc.contributor.icrauthorLaw, Philipen
dc.contributor.icrauthorMarsden,en


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record

https://creativecommons.org/licenses/by/4.0
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0