dc.contributor.author | Law, PJ | |
dc.contributor.author | Berndt, SI | |
dc.contributor.author | Speedy, HE | |
dc.contributor.author | Camp, NJ | |
dc.contributor.author | Sava, GP | |
dc.contributor.author | Skibola, CF | |
dc.contributor.author | Holroyd, A | |
dc.contributor.author | Joseph, V | |
dc.contributor.author | Sunter, NJ | |
dc.contributor.author | Nieters, A | |
dc.contributor.author | Bea, S | |
dc.contributor.author | Monnereau, A | |
dc.contributor.author | Martin-Garcia, D | |
dc.contributor.author | Goldin, LR | |
dc.contributor.author | Clot, G | |
dc.contributor.author | Teras, LR | |
dc.contributor.author | Quintela, I | |
dc.contributor.author | Birmann, BM | |
dc.contributor.author | Jayne, S | |
dc.contributor.author | Cozen, W | |
dc.contributor.author | Majid, A | |
dc.contributor.author | Smedby, KE | |
dc.contributor.author | Lan, Q | |
dc.contributor.author | Dearden, C | |
dc.contributor.author | Brooks-Wilson, AR | |
dc.contributor.author | Hall, AG | |
dc.contributor.author | Purdue, MP | |
dc.contributor.author | Mainou-Fowler, T | |
dc.contributor.author | Vajdic, CM | |
dc.contributor.author | Jackson, GH | |
dc.contributor.author | Cocco, P | |
dc.contributor.author | Marr, H | |
dc.contributor.author | Zhang, Y | |
dc.contributor.author | Zheng, T | |
dc.contributor.author | Giles, GG | |
dc.contributor.author | Lawrence, C | |
dc.contributor.author | Call, TG | |
dc.contributor.author | Liebow, M | |
dc.contributor.author | Melbye, M | |
dc.contributor.author | Glimelius, B | |
dc.contributor.author | Mansouri, L | |
dc.contributor.author | Glenn, M | |
dc.contributor.author | Curtin, K | |
dc.contributor.author | Diver, WR | |
dc.contributor.author | Link, BK | |
dc.contributor.author | Conde, L | |
dc.contributor.author | Bracci, PM | |
dc.contributor.author | Holly, EA | |
dc.contributor.author | Jackson, RD | |
dc.contributor.author | Tinker, LF | |
dc.contributor.author | Benavente, Y | |
dc.contributor.author | Boffetta, P | |
dc.contributor.author | Brennan, P | |
dc.contributor.author | Maynadie, M | |
dc.contributor.author | McKay, J | |
dc.contributor.author | Albanes, D | |
dc.contributor.author | Weinstein, S | |
dc.contributor.author | Wang, Z | |
dc.contributor.author | Caporaso, NE | |
dc.contributor.author | Morton, LM | |
dc.contributor.author | Severson, RK | |
dc.contributor.author | Riboli, E | |
dc.contributor.author | Vineis, P | |
dc.contributor.author | Vermeulen, RCH | |
dc.contributor.author | Southey, MC | |
dc.contributor.author | Milne, RL | |
dc.contributor.author | Clavel, J | |
dc.contributor.author | Topka, S | |
dc.contributor.author | Spinelli, JJ | |
dc.contributor.author | Kraft, P | |
dc.contributor.author | Ennas, MG | |
dc.contributor.author | Summerfield, G | |
dc.contributor.author | Ferri, GM | |
dc.contributor.author | Harris, RJ | |
dc.contributor.author | Miligi, L | |
dc.contributor.author | Pettitt, AR | |
dc.contributor.author | North, KE | |
dc.contributor.author | Allsup, DJ | |
dc.contributor.author | Fraumeni, JF | |
dc.contributor.author | Bailey, JR | |
dc.contributor.author | Offit, K | |
dc.contributor.author | Pratt, G | |
dc.contributor.author | Hjalgrim, H | |
dc.contributor.author | Pepper, C | |
dc.contributor.author | Chanock, SJ | |
dc.contributor.author | Fegan, C | |
dc.contributor.author | Rosenquist, R | |
dc.contributor.author | de Sanjose, S | |
dc.contributor.author | Carracedo, A | |
dc.contributor.author | Dyer, MJS | |
dc.contributor.author | Catovsky, D | |
dc.contributor.author | Campo, E | |
dc.contributor.author | Cerhan, JR | |
dc.contributor.author | Allan, JM | |
dc.contributor.author | Rothman, N | |
dc.contributor.author | Houlston, R | |
dc.contributor.author | Slager, S | |
dc.date.accessioned | 2017-03-06T15:50:39Z | |
dc.date.issued | 2017-02-06 | |
dc.identifier.citation | Nature communications, 2017, 8 pp. 14175 - ? | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/476 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.doi | 10.1038/ncomms14175 | |
dc.description.abstract | Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10-13), 1q42.13 (rs41271473, P=1.06 × 10-10), 4q24 (rs71597109, P=1.37 × 10-10), 4q35.1 (rs57214277, P=3.69 × 10-8), 6p21.31 (rs3800461, P=1.97 × 10-8), 11q23.2 (rs61904987, P=2.64 × 10-11), 18q21.1 (rs1036935, P=3.27 × 10-8), 19p13.3 (rs7254272, P=4.67 × 10-8) and 22q13.33 (rs140522, P=2.70 × 10-9). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response. | |
dc.format | Electronic | |
dc.format.extent | 14175 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | B-Lymphocytes | |
dc.subject | Chromosomes, Human | |
dc.subject | Humans | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Case-Control Studies | |
dc.subject | Chromosome Mapping | |
dc.subject | Antibody Formation | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Adult | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Leukemia, Lymphocytic, Chronic, B-Cell | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Young Adult | |
dc.title | Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-12-06 | |
rioxxterms.versionofrecord | 10.1038/ncomms14175 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2017-02-06 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nature communications | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 8 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Cancer Genomics | |
icr.researchteam | Molecular & Population Genetics | |
dc.contributor.icrauthor | Law, Philip | |
dc.contributor.icrauthor | Sava, Georgina | |
dc.contributor.icrauthor | Houlston, Richard | |