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dc.contributor.authorSalmon, C
dc.contributor.authorSong, L
dc.contributor.authorMuir, K
dc.contributor.authorUKGPCS Collaborators
dc.contributor.authorPashayan, N
dc.contributor.authorDunning, AM
dc.contributor.authorBatra, J
dc.contributor.authorAPCB BioResource (Australian Prostate Cancer BioResource)
dc.contributor.authorChambers, S
dc.contributor.authorStanford, JL
dc.contributor.authorOstrander, EA
dc.contributor.authorPark, JY
dc.contributor.authorLin, H-Y
dc.contributor.authorCussenot, O
dc.contributor.authorCancel-Tassin, G
dc.contributor.authorMenegaux, F
dc.contributor.authorCordina-Duverger, E
dc.contributor.authorKogevinas, M
dc.contributor.authorLlorca, J
dc.contributor.authorKaneva, R
dc.contributor.authorSlavov, C
dc.contributor.authorRazack, A
dc.contributor.authorLim, J
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorCastelao, JE
dc.contributor.authorKote-Jarai, Z
dc.contributor.authorEeles, RA
dc.contributor.authoron behalf of the PRACTICAL Consortium
dc.contributor.authorParent, M-É
dc.date.accessioned2021-08-20T15:08:35Z
dc.date.available2021-08-20T15:08:35Z
dc.date.issued2021-07-18
dc.identifier.citationEuropean journal of epidemiology, 2021
dc.identifier.issn0393-2990
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4772
dc.identifier.eissn1573-7284
dc.identifier.eissn1573-7284en_US
dc.identifier.doi10.1007/s10654-021-00781-1
dc.identifier.doi10.1007/s10654-021-00781-1en_US
dc.description.abstractWhile being in a committed relationship is associated with a better prostate cancer prognosis, little is known about how marital status relates to its incidence. Social support provided by marriage/relationship could promote a healthy lifestyle and an increased healthcare seeking behavior. We investigated the association between marital status and prostate cancer risk using data from the PRACTICAL Consortium. Pooled analyses were conducted combining 12 case-control studies based on histologically-confirmed incident prostate cancers and controls with information on marital status prior to diagnosis/interview. Marital status was categorized as married/partner, separated/divorced, single, or widowed. Tumours with Gleason scores ≥ 8 defined high-grade cancers, and low-grade otherwise. NCI-SEER's summary stages (local, regional, distant) indicated the extent of the cancer. Logistic regression was used to derive odds ratios (ORs) and 95% confidence intervals (CI) for the association between marital status and prostate cancer risk, adjusting for potential confounders. Overall, 14,760 cases and 12,019 controls contributed to analyses. Compared to men who were married/with a partner, widowed men had an OR of 1.19 (95% CI 1.03-1.35) of prostate cancer, with little difference between low- and high-grade tumours. Risk estimates among widowers were 1.14 (95% CI 0.97-1.34) for local, 1.53 (95% CI 1.22-1.92) for regional, and 1.56 (95% CI 1.05-2.32) for distant stage tumours. Single men had elevated risks of high-grade cancers. Our findings highlight elevated risks of incident prostate cancer among widowers, more often characterized by tumours that had spread beyond the prostate at the time of diagnosis. Social support interventions and closer medical follow-up in this sub-population are warranted.
dc.formatPrint-Electronic
dc.languageeng
dc.language.isoeng
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved
dc.subjectUKGPCS Collaborators
dc.subjectAPCB BioResource (Australian Prostate Cancer BioResource)
dc.subjecton behalf of the PRACTICAL Consortium
dc.titleMarital status and prostate cancer incidence: a pooled analysis of 12 case-control studies from the PRACTICAL consortium.
dc.typeJournal Article
dcterms.dateAccepted2021-06-23
rioxxterms.versionAM
rioxxterms.versionofrecord10.1007/s10654-021-00781-1
rioxxterms.licenseref.startdate2021-07-18
rioxxterms.licenseref.startdate2021-07-18en_US
dc.relation.isPartOfEuropean journal of epidemiology
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublished
pubs.embargo.termsNot known
icr.researchteamOncogenetics
icr.researchteamOncogeneticsen_US
dc.contributor.icrauthorEeles, Rosalinden
dc.contributor.icrauthorKote-Jarai, Zsofiaen


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