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dc.contributor.authorPluta, J
dc.contributor.authorPyle, LC
dc.contributor.authorNead, KT
dc.contributor.authorWilf, R
dc.contributor.authorLi, M
dc.contributor.authorMitra, N
dc.contributor.authorWeathers, B
dc.contributor.authorD'Andrea, K
dc.contributor.authorAlmstrup, K
dc.contributor.authorAnson-Cartwright, L
dc.contributor.authorBenitez, J
dc.contributor.authorBrown, CD
dc.contributor.authorChanock, S
dc.contributor.authorChen, C
dc.contributor.authorCortessis, VK
dc.contributor.authorFerlin, A
dc.contributor.authorForesta, C
dc.contributor.authorGamulin, M
dc.contributor.authorGietema, JA
dc.contributor.authorGrasso, C
dc.contributor.authorGreene, MH
dc.contributor.authorGrotmol, T
dc.contributor.authorHamilton, RJ
dc.contributor.authorHaugen, TB
dc.contributor.authorHauser, R
dc.contributor.authorHildebrandt, MAT
dc.contributor.authorJohnson, ME
dc.contributor.authorKarlsson, R
dc.contributor.authorKiemeney, LA
dc.contributor.authorLessel, D
dc.contributor.authorLothe, RA
dc.contributor.authorLoud, JT
dc.contributor.authorLoveday, C
dc.contributor.authorMartin-Gimeno, P
dc.contributor.authorMeijer, C
dc.contributor.authorNsengimana, J
dc.contributor.authorQuinn, DI
dc.contributor.authorRafnar, T
dc.contributor.authorRamdas, S
dc.contributor.authorRichiardi, L
dc.contributor.authorSkotheim, RI
dc.contributor.authorStefansson, K
dc.contributor.authorTurnbull, C
dc.contributor.authorVaughn, DJ
dc.contributor.authorWiklund, F
dc.contributor.authorWu, X
dc.contributor.authorYang, D
dc.contributor.authorZheng, T
dc.contributor.authorWells, AD
dc.contributor.authorGrant, SFA
dc.contributor.authorRajpert-De Meyts, E
dc.contributor.authorSchwartz, SM
dc.contributor.authorBishop, DT
dc.contributor.authorMcGlynn, KA
dc.contributor.authorKanetsky, PA
dc.contributor.authorNathanson, KL
dc.contributor.authorTesticular Cancer Consortium
dc.date.accessioned2021-10-20T11:11:18Z
dc.date.available2021-10-20T11:11:18Z
dc.date.issued2021-07-23
dc.identifier.citationNature communications, 2021, 12 (1), pp. 4487 - ?
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4840
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/s41467-021-24334-y
dc.description.abstractTesticular germ cell tumors (TGCT) are the most common tumor in young white men and have a high heritability. In this study, the international Testicular Cancer Consortium assemble 10,156 and 179,683 men with and without TGCT, respectively, for a genome-wide association study. This meta-analysis identifies 22 TGCT susceptibility loci, bringing the total to 78, which account for 44% of disease heritability. Men with a polygenic risk score (PRS) in the 95 th percentile have a 6.8-fold increased risk of TGCT compared to men with median scores. Among men with independent TGCT risk factors such as cryptorchidism, the PRS may guide screening decisions with the goal of reducing treatment-related complications causing long-term morbidity in survivors. These findings emphasize the interconnected nature of two known pathways that promote TGCT susceptibility: male germ cell development within its somatic niche and regulation of chromosomal division and structure, and implicate an additional biological pathway, mRNA translation.
dc.formatElectronic
dc.format.extent4487 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectTesticular Cancer Consortium
dc.subjectCell Line, Tumor
dc.subjectHumans
dc.subjectNeoplasms, Germ Cell and Embryonal
dc.subjectTesticular Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectChromosome Mapping
dc.subjectGenotype
dc.subjectLinkage Disequilibrium
dc.subjectPolymorphism, Single Nucleotide
dc.subjectMale
dc.subjectGene Regulatory Networks
dc.subjectMeta-Analysis as Topic
dc.subjectGenome-Wide Association Study
dc.subjectProtein Interaction Maps
dc.titleIdentification of 22 susceptibility loci associated with testicular germ cell tumors.
dc.typeJournal Article
dcterms.dateAccepted2021-06-01
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41467-021-24334-y
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2021-07-23
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature communications
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.publication-statusPublished
pubs.volume12
pubs.embargo.termsNot known
dc.contributor.icrauthorTurnbull, Clareen


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