A Cross-Machine Comparison of Shear-Wave Speed Measurements Using 2D Shear-Wave Elastography in the Normal Female Breast
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Date
2021-10-01ICR Author
Author
Harris, E
Sinnatamby, R
O'Flynn, E
Kirby, AM
Bamber, JC
Type
Journal Article
Metadata
Show full item recordAbstract
<jats:p>Quantitative measures of radiation-induced breast stiffness are required to support clinical studies of novel breast radiotherapy regimens and exploration of personalised therapy, however, variation between shear-wave elastography (SWE) machines may limit the usefulness of shear-wave speed (cs) for this purpose. Mean cs measured in four healthy volunteers’ breasts and a phantom using 2D-SWE machines Acuson S2000 (Siemens Medical Solutions) and Aixplorer (Supersonic Imagine) were compared. Shear-wave speed was measured in the skin region, subcutaneous adipose tissue and parenchyma. cs estimates were on average 2.3% greater when using the Aixplorer compared to S2000 in vitro. In vivo, cs estimates were on average 43.7%, 36.3% and 49.9% significantly greater (p << 0.01) when using the Aixplorer compared to S2000, for skin region, subcutaneous adipose tissue and parenchyma, respectively. In conclusion, despite relatively small differences between machines observed in vitro, large differences in absolute measures of shear wave speed measured were observed in vivo, which may prevent pooling of cross-machine data in clinical studies of the breast.</jats:p>
Collections
Subject
Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Engineering, Multidisciplinary
Materials Science, Multidisciplinary
Physics, Applied
Chemistry
Engineering
Materials Science
Physics
shear-wave elastography
shear-wave speed
radiation-induced breast toxicity
tissue stiffness
cross-machine comparison
1 BASIC PRINCIPLES
ULTRASOUND ELASTOGRAPHY
RADIATION FORCE
CLINICAL-USE
QUANTITATIVE ASSESSMENT
EFSUMB GUIDELINES
WFUMB GUIDELINES
SKIN STIFFNESS
RECOMMENDATIONS
QUANTIFICATION
Research team
Breast Cancer Radiotherapy
Ultrasound & Optical Imaging
Language
eng
Date accepted
2021-10-03
License start date
2021-10-01
Citation
APPLIED SCIENCES-BASEL, 2021, 11 (20), pp. ? - ? (16)
Publisher
MDPI