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dc.contributor.authorGuerreiro, Fen_US
dc.contributor.authorBurgos, Nen_US
dc.contributor.authorDunlop, Aen_US
dc.contributor.authorWong, Ken_US
dc.contributor.authorPetkar, Ien_US
dc.contributor.authorNutting, Cen_US
dc.contributor.authorHarrington, Ken_US
dc.contributor.authorBhide, Sen_US
dc.contributor.authorNewbold, Ken_US
dc.contributor.authorDearnaley, Den_US
dc.contributor.authordeSouza, NMen_US
dc.contributor.authorMorgan, VAen_US
dc.contributor.authorMcClelland, Jen_US
dc.contributor.authorNill, Sen_US
dc.contributor.authorCardoso, MJen_US
dc.contributor.authorOurselin, Sen_US
dc.contributor.authorOelfke, Uen_US
dc.contributor.authorKnopf, ACen_US
dc.identifier.citationPhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 2017, 35 pp. 7 - 17en_US
dc.description.abstractBACKGROUND AND PURPOSE:Computed tomography (CT) imaging is the current gold standard for radiotherapy treatment planning (RTP). The establishment of a magnetic resonance imaging (MRI) only RTP workflow requires the generation of a synthetic CT (sCT) for dose calculation. This study evaluates the feasibility of using a multi-atlas sCT synthesis approach (sCTa) for head and neck and prostate patients. MATERIAL AND METHODS:The multi-atlas method was based on pairs of non-rigidly aligned MR and CT images. The sCTa was obtained by registering the MRI atlases to the patient's MRI and by fusing the mapped atlases according to morphological similarity to the patient. For comparison, a bulk density assignment approach (sCTbda) was also evaluated. The sCTbda was obtained by assigning density values to MRI tissue classes (air, bone and soft-tissue). After evaluating the synthesis accuracy of the sCTs (mean absolute error), sCT-based delineations were geometrically compared to the CT-based delineations. Clinical plans were re-calculated on both sCTs and a dose-volume histogram and a gamma analysis was performed using the CT dose as ground truth. RESULTS:Results showed that both sCTs were suitable to perform clinical dose calculations with mean dose differences less than 1% for both the planning target volume and the organs at risk. However, only the sCTa provided an accurate and automatic delineation of bone. CONCLUSIONS:Combining MR delineations with our multi-atlas CT synthesis method could enable MRI-only treatment planning and thus improve the dosimetric and geometric accuracy of the treatment, and reduce the number of imaging procedures.en_US
dc.format.extent7 - 17en_US
dc.subjectOropharyngeal Neoplasmsen_US
dc.subjectProstatic Neoplasmsen_US
dc.subjectTomography, X-Ray Computeden_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectRadiotherapy Dosageen_US
dc.subjectRadiotherapy Planning, Computer-Assisteden_US
dc.subjectRetrospective Studiesen_US
dc.subjectFeasibility Studiesen_US
dc.subjectRadiotherapy, Intensity-Modulateden_US
dc.subjectAtlases as Topicen_US
dc.titleEvaluation of a multi-atlas CT synthesis approach for MRI-only radiotherapy treatment planning.en_US
dc.typeJournal Article
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfPhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Dearnaley)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.embargo.termsNo embargoen_US
icr.researchteamClinical Academic Radiotherapy (Dearnaley)en_US
icr.researchteamMagnetic Resonanceen_US
icr.researchteamRadiotherapy Physics Modellingen_US
icr.researchteamTargeted Therapyen_US
dc.contributor.icrauthorNill, Simeonen_US
dc.contributor.icrauthorDearnaley, Daviden_US
dc.contributor.icrauthorOelfke, Uween_US
dc.contributor.icrauthorHarrington, Kevinen_US
dc.contributor.icrauthordeSouza, Nanditaen_US

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