dc.contributor.author | McVeigh, UM | |
dc.contributor.author | Tepper, JW | |
dc.contributor.author | McVeigh, TP | |
dc.date.accessioned | 2022-01-17T09:41:09Z | |
dc.date.available | 2022-01-17T09:41:09Z | |
dc.date.issued | 2021-11-05 | |
dc.identifier.citation | Cancers, 2021, 13 (21) | |
dc.identifier.issn | 2072-6694 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4959 | |
dc.identifier.eissn | 2072-6694 | |
dc.identifier.eissn | 2072-6694 | |
dc.identifier.doi | 10.3390/cancers13215552 | |
dc.identifier.doi | 10.3390/cancers13215552 | |
dc.description.abstract | Cancer in adolescents and young adults (AYAs) deserves special consideration for several reasons. AYA cancers encompass paediatric malignancies that present at an older age than expected, or early-onset of cancers that are typically observed in adults. However, disease diagnosed in the AYA population is distinct to those same cancers which are diagnosed in a paediatric or older adult setting. Worse disease-free and overall survival outcomes are observed in the AYA setting, and the incidence of AYA cancers is increasing. Knowledge of an individual's underlying cancer predisposition can influence their clinical care and may facilitate early tumour surveillance strategies and cascade testing of at-risk relatives. This information can further influence reproductive decision making. In this review we discuss the risk factors contributing to AYA breast cancer, such as heritable predisposition, environmental, and lifestyle factors. We also describe a number of risk models which incorporate genetic factors that aid clinicians in quantifying an individual's lifetime risk of disease. | |
dc.format | Electronic | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | MDPI | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | A Review of Breast Cancer Risk Factors in Adolescents and Young Adults. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2021-11-03 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.3390/cancers13215552 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2021-11-05 | |
dc.relation.isPartOf | Cancers | |
pubs.issue | 21 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genetics Education & Quality Improvement | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 13 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Cancer Genetics Education & Quality Improvement | |
dc.contributor.icrauthor | McVeigh, Terri | |