A Review of Breast Cancer Risk Factors in Adolescents and Young Adults.
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Date
2021-11-05ICR Author
Author
McVeigh, UM
Tepper, JW
McVeigh, TP
Type
Journal Article
Metadata
Show full item recordAbstract
Cancer in adolescents and young adults (AYAs) deserves special consideration for several reasons. AYA cancers encompass paediatric malignancies that present at an older age than expected, or early-onset of cancers that are typically observed in adults. However, disease diagnosed in the AYA population is distinct to those same cancers which are diagnosed in a paediatric or older adult setting. Worse disease-free and overall survival outcomes are observed in the AYA setting, and the incidence of AYA cancers is increasing. Knowledge of an individual's underlying cancer predisposition can influence their clinical care and may facilitate early tumour surveillance strategies and cascade testing of at-risk relatives. This information can further influence reproductive decision making. In this review we discuss the risk factors contributing to AYA breast cancer, such as heritable predisposition, environmental, and lifestyle factors. We also describe a number of risk models which incorporate genetic factors that aid clinicians in quantifying an individual's lifetime risk of disease.
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Research team
Cancer Genetics Education & Quality Improvement
Language
eng
Date accepted
2021-11-03
License start date
2021-11-05
Citation
Cancers, 2021, 13 (21)
Publisher
MDPI