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dc.contributor.authorFendler, A
dc.contributor.authorAu, L
dc.contributor.authorShepherd, STC
dc.contributor.authorByrne, F
dc.contributor.authorCerrone, M
dc.contributor.authorBoos, LA
dc.contributor.authorRzeniewicz, K
dc.contributor.authorGordon, W
dc.contributor.authorShum, B
dc.contributor.authorGerard, CL
dc.contributor.authorWard, B
dc.contributor.authorXie, W
dc.contributor.authorSchmitt, AM
dc.contributor.authorJoharatnam-Hogan, N
dc.contributor.authorCornish, GH
dc.contributor.authorPule, M
dc.contributor.authorMekkaoui, L
dc.contributor.authorNg, KW
dc.contributor.authorCarlyle, E
dc.contributor.authorEdmonds, K
dc.contributor.authorRosario, LD
dc.contributor.authorSarker, S
dc.contributor.authorLingard, K
dc.contributor.authorMangwende, M
dc.contributor.authorHolt, L
dc.contributor.authorAhmod, H
dc.contributor.authorStone, R
dc.contributor.authorGomes, C
dc.contributor.authorFlynn, HR
dc.contributor.authorAgua-Doce, A
dc.contributor.authorHobson, P
dc.contributor.authorCaidan, S
dc.contributor.authorHowell, M
dc.contributor.authorWu, M
dc.contributor.authorGoldstone, R
dc.contributor.authorCrawford, M
dc.contributor.authorCubitt, L
dc.contributor.authorPatel, H
dc.contributor.authorGavrielides, M
dc.contributor.authorNye, E
dc.contributor.authorSnijders, AP
dc.contributor.authorMacRae, JI
dc.contributor.authorNicod, J
dc.contributor.authorGronthoud, F
dc.contributor.authorShea, RL
dc.contributor.authorMessiou, C
dc.contributor.authorCunningham, D
dc.contributor.authorChau, I
dc.contributor.authorStarling, N
dc.contributor.authorTurner, N
dc.contributor.authorWelsh, L
dc.contributor.authorvan As, N
dc.contributor.authorJones, RL
dc.contributor.authorDroney, J
dc.contributor.authorBanerjee, S
dc.contributor.authorTatham, KC
dc.contributor.authorJhanji, S
dc.contributor.authorO'Brien, M
dc.contributor.authorCurtis, O
dc.contributor.authorHarrington, K
dc.contributor.authorBhide, S
dc.contributor.authorBazin, J
dc.contributor.authorRobinson, A
dc.contributor.authorStephenson, C
dc.contributor.authorSlattery, T
dc.contributor.authorKhan, Y
dc.contributor.authorTippu, Z
dc.contributor.authorLeslie, I
dc.contributor.authorGennatas, S
dc.contributor.authorOkines, A
dc.contributor.authorReid, A
dc.contributor.authorYoung, K
dc.contributor.authorFurness, AJS
dc.contributor.authorPickering, L
dc.contributor.authorGandhi, S
dc.contributor.authorGamblin, S
dc.contributor.authorSwanton, C
dc.contributor.authorCrick COVID-19 Consortium,
dc.contributor.authorNicholson, E
dc.contributor.authorKumar, S
dc.contributor.authorYousaf, N
dc.contributor.authorWilkinson, KA
dc.contributor.authorSwerdlow, A
dc.contributor.authorHarvey, R
dc.contributor.authorKassiotis, G
dc.contributor.authorLarkin, J
dc.contributor.authorWilkinson, RJ
dc.contributor.authorTurajlic, S
dc.contributor.authorCAPTURE consortium,
dc.date.accessioned2022-01-17T09:53:59Z
dc.date.available2022-01-17T09:53:59Z
dc.date.issued2021-09-20
dc.identifier.citationNature Cancer, 2021, 2 (12), pp. 1321 - 1337
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4961
dc.identifier.eissn2662-1347
dc.identifier.eissn2662-1347
dc.identifier.doi10.1038/s43018-021-00275-9
dc.identifier.doi10.1038/s43018-021-00275-9
dc.description.abstractPatients with cancer have higher COVID-19 morbidity and mortality. Here we present the prospective CAPTURE study, integrating longitudinal immune profiling with clinical annotation. Of 357 patients with cancer, 118 were SARS-CoV-2 positive, 94 were symptomatic and 2 died of COVID-19. In this cohort, 83% patients had S1-reactive antibodies and 82% had neutralizing antibodies against wild type SARS-CoV-2, whereas neutralizing antibody titers against the Alpha, Beta and Delta variants were substantially reduced. S1-reactive antibody levels decreased in 13% of patients, whereas neutralizing antibody titers remained stable for up to 329 days. Patients also had detectable SARS-CoV-2-specific T cells and CD4+ responses correlating with S1-reactive antibody levels, although patients with hematological malignancies had impaired immune responses that were disease and treatment specific, but presented compensatory cellular responses, further supported by clinical recovery in all but one patient. Overall, these findings advance the understanding of the nature and duration of the immune response to SARS-CoV-2 in patients with cancer.
dc.format.extent1321 - 1337
dc.languageen
dc.language.isoeng
dc.publisherNATURE PORTFOLIO
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleFunctional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study.
dc.typeJournal Article
dcterms.dateAccepted2021-09-17
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s43018-021-00275-9
dc.relation.isPartOfNature Cancer
pubs.issue12
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/ImmNet
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Melanoma and Kidney Cancer
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/MD(Res)
pubs.organisational-group/ICR/Students/MD(Res)/Starting Cohort 20/21
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/18/19 Starting Cohort
pubs.publication-statusPublished
pubs.volume2
pubs.embargo.termsNot known
icr.researchteamMedicine (RMH Smith Cunningham)
icr.researchteamMelanoma and Kidney Cancer
icr.researchteamTargeted Therapy
dc.contributor.icrauthorAu, Lewis
dc.contributor.icrauthorShepherd, Scott
dc.contributor.icrauthorShum, Ben
dc.contributor.icrauthorTurner, Nicholas
dc.contributor.icrauthorCurtis, Olivia
dc.contributor.icrauthorHarrington, Kevin
dc.contributor.icrauthorBhide, Shreerang
dc.contributor.icrauthorFurness, Andrew


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