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Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.

dc.contributor.authorLin, W-Y
dc.contributor.authorFordham, SE
dc.contributor.authorHungate, E
dc.contributor.authorSunter, NJ
dc.contributor.authorElstob, C
dc.contributor.authorXu, Y
dc.contributor.authorPark, C
dc.contributor.authorQuante, A
dc.contributor.authorStrauch, K
dc.contributor.authorGieger, C
dc.contributor.authorSkol, A
dc.contributor.authorRahman, T
dc.contributor.authorSucheston-Campbell, L
dc.contributor.authorWang, J
dc.contributor.authorHahn, T
dc.contributor.authorClay-Gilmour, AI
dc.contributor.authorJones, GL
dc.contributor.authorMarr, HJ
dc.contributor.authorJackson, GH
dc.contributor.authorMenne, T
dc.contributor.authorCollin, M
dc.contributor.authorIvey, A
dc.contributor.authorHills, RK
dc.contributor.authorBurnett, AK
dc.contributor.authorRussell, NH
dc.contributor.authorFitzgibbon, J
dc.contributor.authorLarson, RA
dc.contributor.authorLe Beau, MM
dc.contributor.authorStock, W
dc.contributor.authorHeidenreich, O
dc.contributor.authorAlharbi, A
dc.contributor.authorAllsup, DJ
dc.contributor.authorHoulston, RS
dc.contributor.authorNorden, J
dc.contributor.authorDickinson, AM
dc.contributor.authorDouglas, E
dc.contributor.authorLendrem, C
dc.contributor.authorDaly, AK
dc.contributor.authorPalm, L
dc.contributor.authorPiechocki, K
dc.contributor.authorJeffries, S
dc.contributor.authorBornhäuser, M
dc.contributor.authorRöllig, C
dc.contributor.authorAltmann, H
dc.contributor.authorRuhnke, L
dc.contributor.authorKunadt, D
dc.contributor.authorWagenführ, L
dc.contributor.authorCordell, HJ
dc.contributor.authorDarlay, R
dc.contributor.authorAndersen, MK
dc.contributor.authorFontana, MC
dc.contributor.authorMartinelli, G
dc.contributor.authorMarconi, G
dc.contributor.authorSanz, MA
dc.contributor.authorCervera, J
dc.contributor.authorGómez-Seguí, I
dc.contributor.authorCluzeau, T
dc.contributor.authorMoreilhon, C
dc.contributor.authorRaynaud, S
dc.contributor.authorSill, H
dc.contributor.authorVoso, MT
dc.contributor.authorLo-Coco, F
dc.contributor.authorDombret, H
dc.contributor.authorCheok, M
dc.contributor.authorPreudhomme, C
dc.contributor.authorGale, RE
dc.contributor.authorLinch, D
dc.contributor.authorGaal-Wesinger, J
dc.contributor.authorMasszi, A
dc.contributor.authorNowak, D
dc.contributor.authorHofmann, W-K
dc.contributor.authorGilkes, A
dc.contributor.authorPorkka, K
dc.contributor.authorMilosevic Feenstra, JD
dc.contributor.authorKralovics, R
dc.contributor.authorGrimwade, D
dc.contributor.authorMeggendorfer, M
dc.contributor.authorHaferlach, T
dc.contributor.authorKrizsán, S
dc.contributor.authorBödör, C
dc.contributor.authorStölzel, F
dc.contributor.authorOnel, K
dc.contributor.authorAllan, JM
dc.date.accessioned2022-01-18T15:02:11Z
dc.date.available2022-01-18T15:02:11Z
dc.date.issued2021-10-29
dc.identifier.citationNature communications, 2021, 12 (1), pp. 6233 - ?
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4964
dc.identifier.eissn2041-1723
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/s41467-021-26551-x
dc.identifier.doi10.1038/s41467-021-26551-x
dc.description.abstractAcute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10-8; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10-10; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).
dc.formatElectronic
dc.format.extent6233 - ?
dc.languageeng
dc.language.isoeng
dc.publisherNATURE PORTFOLIO
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleGenome-wide association study identifies susceptibility loci for acute myeloid leukemia.
dc.typeJournal Article
dcterms.dateAccepted2021-10-01
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41467-021-26551-x
rioxxterms.licenseref.startdate2021-10-29
dc.relation.isPartOfNature communications
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.publication-statusPublished
pubs.volume12
pubs.embargo.termsNot known
icr.researchteamCancer Genomics
dc.contributor.icrauthorHoulston, Richard


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