Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.
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Date
2021-10-29ICR Author
Author
Lin, W-Y
Fordham, SE
Hungate, E
Sunter, NJ
Elstob, C
Xu, Y
Park, C
Quante, A
Strauch, K
Gieger, C
Skol, A
Rahman, T
Sucheston-Campbell, L
Wang, J
Hahn, T
Clay-Gilmour, AI
Jones, GL
Marr, HJ
Jackson, GH
Menne, T
Collin, M
Ivey, A
Hills, RK
Burnett, AK
Russell, NH
Fitzgibbon, J
Larson, RA
Le Beau, MM
Stock, W
Heidenreich, O
Alharbi, A
Allsup, DJ
Houlston, RS
Norden, J
Dickinson, AM
Douglas, E
Lendrem, C
Daly, AK
Palm, L
Piechocki, K
Jeffries, S
Bornhäuser, M
Röllig, C
Altmann, H
Ruhnke, L
Kunadt, D
Wagenführ, L
Cordell, HJ
Darlay, R
Andersen, MK
Fontana, MC
Martinelli, G
Marconi, G
Sanz, MA
Cervera, J
Gómez-Seguí, I
Cluzeau, T
Moreilhon, C
Raynaud, S
Sill, H
Voso, MT
Lo-Coco, F
Dombret, H
Cheok, M
Preudhomme, C
Gale, RE
Linch, D
Gaal-Wesinger, J
Masszi, A
Nowak, D
Hofmann, W-K
Gilkes, A
Porkka, K
Milosevic Feenstra, JD
Kralovics, R
Grimwade, D
Meggendorfer, M
Haferlach, T
Krizsán, S
Bödör, C
Stölzel, F
Onel, K
Allan, JM
Type
Journal Article
Metadata
Show full item recordAbstract
Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10-8; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10-10; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).
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Research team
Cancer Genomics
Language
eng
Date accepted
2021-10-01
License start date
2021-10-29
Citation
Nature communications, 2021, 12 (1), pp. 6233 - ?
Publisher
NATURE PORTFOLIO