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dc.contributor.authorKumar, M
dc.contributor.authorMichael, S
dc.contributor.authorAlvarado-Valverde, J
dc.contributor.authorMészáros, B
dc.contributor.authorSámano-Sánchez, H
dc.contributor.authorZeke, A
dc.contributor.authorDobson, L
dc.contributor.authorLazar, T
dc.contributor.authorÖrd, M
dc.contributor.authorNagpal, A
dc.contributor.authorFarahi, N
dc.contributor.authorKäser, M
dc.contributor.authorKraleti, R
dc.contributor.authorDavey, NE
dc.contributor.authorPancsa, R
dc.contributor.authorChemes, LB
dc.contributor.authorGibson, TJ
dc.date.accessioned2022-01-26T16:00:23Z
dc.date.available2022-01-26T16:00:23Z
dc.identifier.citationNucleic acids research, 2022, 50 (D1), pp. D497 - D508en_US
dc.identifier.issn0305-1048
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4979
dc.identifier.eissn1362-4962en_US
dc.identifier.eissn1362-4962
dc.identifier.doi10.1093/nar/gkab975en_US
dc.identifier.doi10.1093/nar/gkab975
dc.description.abstractAlmost twenty years after its initial release, the Eukaryotic Linear Motif (ELM) resource remains an invaluable source of information for the study of motif-mediated protein-protein interactions. ELM provides a comprehensive, regularly updated and well-organised repository of manually curated, experimentally validated short linear motifs (SLiMs). An increasing number of SLiM-mediated interactions are discovered each year and keeping the resource up-to-date continues to be a great challenge. In the current update, 30 novel motif classes have been added and five existing classes have undergone major revisions. The update includes 411 new motif instances mostly focused on cell-cycle regulation, control of the actin cytoskeleton, membrane remodelling and vesicle trafficking pathways, liquid-liquid phase separation and integrin signalling. Many of the newly annotated motif-mediated interactions are targets of pathogenic motif mimicry by viral, bacterial or eukaryotic pathogens, providing invaluable insights into the molecular mechanisms underlying infectious diseases. The current ELM release includes 317 motif classes incorporating 3934 individual motif instances manually curated from 3867 scientific publications. ELM is available at: http://elm.eu.org.en_US
dc.formatPrinten_US
dc.format.extentD497 - D508en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleThe Eukaryotic Linear Motif resource: 2022 release.en_US
dc.typeJournal Article
dcterms.dateAccepted2021-10-27
rioxxterms.versionVoRen_US
rioxxterms.versionofrecord10.1093/nar/gkab975en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.relation.isPartOfNucleic acids researchen_US
pubs.issueD1en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.publication-statusPublisheden_US
pubs.volume50en_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorDavey, Normanen_US


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