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dc.contributor.authorRush, HL
dc.contributor.authorMurphy, L
dc.contributor.authorMorgans, AK
dc.contributor.authorClarke, NW
dc.contributor.authorCook, AD
dc.contributor.authorAttard, G
dc.contributor.authorMacnair, A
dc.contributor.authorDearnaley, DP
dc.contributor.authorParker, CC
dc.contributor.authorRussell, JM
dc.contributor.authorGillessen, S
dc.contributor.authorMatheson, D
dc.contributor.authorMillman, R
dc.contributor.authorBrawley, CD
dc.contributor.authorPugh, C
dc.contributor.authorTanguay, JS
dc.contributor.authorJones, RJ
dc.contributor.authorWagstaff, J
dc.contributor.authorRudman, S
dc.contributor.authorO'Sullivan, JM
dc.contributor.authorGale, J
dc.contributor.authorBirtle, A
dc.contributor.authorProtheroe, A
dc.contributor.authorGray, E
dc.contributor.authorPerna, C
dc.contributor.authorTolan, S
dc.contributor.authorMcPhail, N
dc.contributor.authorMalik, ZI
dc.contributor.authorVengalil, S
dc.contributor.authorFackrell, D
dc.contributor.authorHoskin, P
dc.contributor.authorSydes, MR
dc.contributor.authorChowdhury, S
dc.contributor.authorGilbert, DC
dc.contributor.authorParmar, MKB
dc.contributor.authorJames, ND
dc.contributor.authorLangley, RE
dc.date.accessioned2022-02-03T11:22:41Z
dc.date.available2022-02-03T11:22:41Z
dc.date.issued2022-03-10
dc.identifier.citationJournal of clinical oncology : official journal of the American Society of Clinical Oncology, 2021, pp. JCO2100728 - ?
dc.identifier.issn0732-183X
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4997
dc.identifier.eissn1527-7755
dc.identifier.eissn1527-7755
dc.identifier.doi10.1200/jco.21.00728
dc.identifier.doi10.1200/jco.21.00728
dc.description.abstractPURPOSE: Docetaxel and abiraterone acetate plus prednisone or prednisolone (AAP) both improve survival when commenced alongside standard of care (SOC) androgen deprivation therapy in locally advanced or metastatic hormone-sensitive prostate cancer. Thus, patient-reported quality of life (QOL) data may guide treatment choices. METHODS: A group of patients within the STAMPEDE trial were contemporaneously enrolled with the possibility of being randomly allocated to receive either docetaxel + SOC or AAP + SOC. A mixed-model assessed QOL in those who had completed at least one QLQ-C30 + PR25 questionnaire. The primary outcome measure was difference in global-QOL (QLQ-C30 Q29&30) between patients allocated to docetaxel + SOC or AAP + SOC over the 2 years after random assignment, with a predefined criterion for clinically meaningful difference of > 4.0 points. Secondary outcome measures included longitudinal comparison of functional domains, pain, and fatigue, plus global-QOL at defined timepoints. RESULTS: Five hundred fifteen patients (173 docetaxel + SOC and 342 AAP + SOC) were included. Baseline characteristics, proportion of missing data, and mean baseline global-QOL scores (docetaxel + SOC 77.8 and AAP + SOC 78.0) were similar. Over the 2 years following random assignment, the mean modeled global-QOL score was +3.9 points (95% CI, +0.5 to +7.2; P = .022) higher in patients allocated to AAP + SOC. Global-QOL was higher for patients allocated to AAP + SOC over the first year (+5.7 points, 95% CI, +3.0 to +8.5; P < .001), particularly at 12 (+7.0 points, 95% CI, +3.0 to +11.0; P = .001) and 24 weeks (+8.3 points, 95% CI, +4.0 to +12.6; P < .001). CONCLUSION: Patient-reported QOL was superior for patients allocated to receive AAP + SOC, compared with docetaxel + SOC over a 2-year period, narrowly missing the predefined value for clinical significance. Patients receiving AAP + SOC reported clinically meaningful higher global-QOL scores throughout the first year following random assignment.
dc.formatPrint-Electronic
dc.format.extentJCO2100728 - ?
dc.languageeng
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleQuality of Life in Men With Prostate Cancer Randomly Allocated to Receive Docetaxel or Abiraterone in the STAMPEDE Trial.
dc.typeJournal Article
dcterms.dateAccepted2021-10-01
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1200/jco.21.00728
rioxxterms.licenseref.startdate2021-11-10
dc.relation.isPartOfJournal of clinical oncology : official journal of the American Society of Clinical Oncology
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/ImmNet
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Clinical Academic Radiotherapy (Dearnaley)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Prostate and Bladder Cancer Research
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.embargo.termsNot known
icr.researchteamClinical Academic Radiotherapy (Dearnaley)
icr.researchteamProstate and Bladder Cancer Research
dc.contributor.icrauthorDearnaley, David
dc.contributor.icrauthorJames, Nicholas


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