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dc.contributor.authorFerreira, MR
dc.contributor.authorSands, CJ
dc.contributor.authorLi, JV
dc.contributor.authorAndreyev, JN
dc.contributor.authorChekmeneva, E
dc.contributor.authorGulliford, S
dc.contributor.authorMarchesi, J
dc.contributor.authorLewis, MR
dc.contributor.authorDearnaley, DP
dc.date.accessioned2022-02-18T11:19:59Z
dc.date.available2022-02-18T11:19:59Z
dc.date.issued2021-12-01
dc.identifier.citationInternational journal of radiation oncology, biology, physics, 2021, 111 (5), pp. 1204 - 1213
dc.identifier.issn0360-3016
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/5019
dc.identifier.eissn1879-355X
dc.identifier.eissn1879-355X
dc.identifier.doi10.1016/j.ijrobp.2021.07.1713
dc.identifier.doi10.1016/j.ijrobp.2021.07.1713
dc.description.abstractPURPOSE: Radiation therapy to the prostate and pelvic lymph nodes (PLNRT) is part of the curative treatment of high-risk prostate cancer. Yet, the broader influence of radiation therapy on patient physiology is poorly understood. We conducted comprehensive global metabolomic profiling of urine, plasma, and stools sampled from patients undergoing PLNRT for high-risk prostate cancer. METHODS AND MATERIALS: Samples were taken from 32 patients at 6 timepoints: baseline, 2 to 3 and 4 to 5 weeks of PLNRT; and 3, 6, and 12 months after PLNRT. We characterized the global metabolome of urine and plasma using 1H nuclear magnetic resonance spectroscopy and ultraperformance liquid chromatography-mass spectrometry, and of stools with nuclear magnetic resonance. Linear mixed-effects modeling was used to investigate metabolic changes between timepoints for each biofluid and assay and determine metabolites of interest. RESULTS: Metabolites in urine, plasma and stools changed significantly after PLNRT initiation. Metabolic profiles did not return to baseline up to 1 year post-PLNRT in any biofluid. Molecules associated with cardiovascular risk were increased in plasma. Pre-PLNRT fecal butyrate levels directly associated with increasing gastrointestinal side effects, as did a sharper fall in those levels during and up to 1 year postradiation therapy, mirroring our previous results with metataxonomics. CONCLUSIONS: We showed for the first time that an overall metabolic effect is observed in patients undergoing PLNRT up to 1 year posttreatment. These metabolic changes may effect on long-term morbidity after treatment, which warrants further investigation.
dc.formatPrint-Electronic
dc.format.extent1204 - 1213
dc.languageeng
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleImpact of Pelvic Radiation Therapy for Prostate Cancer on Global Metabolic Profiles and Microbiota-Driven Gastrointestinal Late Side Effects: A Longitudinal Observational Study.
dc.typeJournal Article
dcterms.dateAccepted2021-07-26
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1016/j.ijrobp.2021.07.1713
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.relation.isPartOfInternational journal of radiation oncology, biology, physics
pubs.issue5
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Clinical Academic Radiotherapy (Dearnaley)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.publication-statusPublished
pubs.volume111
pubs.embargo.termsNot known
icr.researchteamClinical Academic Radiotherapy (Dearnaley)
icr.researchteamRadiotherapy Physics Modelling
dc.contributor.icrauthorDearnaley, David


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