dc.contributor.author | Gillison, ML | |
dc.contributor.author | Blumenschein, G | |
dc.contributor.author | Fayette, J | |
dc.contributor.author | Guigay, J | |
dc.contributor.author | Colevas, AD | |
dc.contributor.author | Licitra, L | |
dc.contributor.author | Harrington, KJ | |
dc.contributor.author | Kasper, S | |
dc.contributor.author | Vokes, EE | |
dc.contributor.author | Even, C | |
dc.contributor.author | Worden, F | |
dc.contributor.author | Saba, NF | |
dc.contributor.author | Iglesias Docampo, LC | |
dc.contributor.author | Haddad, R | |
dc.contributor.author | Rordorf, T | |
dc.contributor.author | Kiyota, N | |
dc.contributor.author | Tahara, M | |
dc.contributor.author | Jayaprakash, V | |
dc.contributor.author | Wei, L | |
dc.contributor.author | Ferris, RL | |
dc.date.accessioned | 2022-04-06T10:11:35Z | |
dc.date.available | 2022-04-06T10:11:35Z | |
dc.date.issued | 2022-03-04 | |
dc.identifier | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000764264500021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4b848928d1c3e5c86d298abb68475f9 | |
dc.identifier.citation | ONCOLOGIST, 2022, 27 (2), pp. E194 - E198 (5) | |
dc.identifier.issn | 1083-7159 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5073 | |
dc.identifier.eissn | 1549-490X | |
dc.identifier.eissn | 1549-490X | |
dc.identifier.doi | 10.1093/oncolo/oyab036 | |
dc.identifier.doi | 10.1093/oncolo/oyab036 | |
dc.description.abstract | In the randomized, phase 3 CheckMate 141 trial, nivolumab significantly improved overall survival (OS) versus investigator's choice (IC) of chemotherapy at primary analysis among 361 patients with recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) post-platinum therapy. Nivolumab versus IC as first-line treatment also improved OS among patients with R/M SCCHN who progressed on platinum therapy for locally advanced disease in the adjuvant or primary setting at 1-year follow-up. In the present long-term follow-up analysis of patients receiving first-line treatment, OS benefit with nivolumab (n = 50) versus IC (n = 26) was maintained (median: 7.7 months versus 3.3 months; hazard ratio: 0.56; 95% confidence interval, 0.34-0.94) at 2 years. No new safety signals were identified. In summary, this long-term 2-year analysis of CheckMate 141 supports the use of nivolumab as a first-line treatment for patients with platinum-refractory R/M SCCHN. | |
dc.format.extent | E194 - E198 (5) | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | OXFORD UNIV PRESS | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0 | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Oncology | |
dc.subject | clinical trial | |
dc.subject | squamous cell carcinoma of head and neck | |
dc.subject | nivolumab | |
dc.subject | immunotherapy | |
dc.subject | SQUAMOUS-CELL CARCINOMA | |
dc.subject | INVESTIGATORS CHOICE | |
dc.subject | OPEN-LABEL | |
dc.subject | CETUXIMAB | |
dc.subject | CHEMOTHERAPY | |
dc.subject | PLATINUM | |
dc.title | Long-term Outcomes with Nivolumab as First-line Treatment in Recurrent or Metastatic Head and Neck Cancer: Subgroup Analysis of CheckMate 141. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2021-11-30 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1093/oncolo/oyab036 | |
rioxxterms.licenseref.startdate | 2022-03-04 | |
dc.relation.isPartOf | ONCOLOGIST | |
pubs.issue | 2 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/ImmNet | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy | |
pubs.publication-status | Published | |
pubs.volume | 27 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Targeted Therapy | |
dc.contributor.icrauthor | Harrington, Kevin | |