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dc.contributor.authorDouzinas, EE
dc.contributor.authorAndrianakis, I
dc.contributor.authorLivaditi, O
dc.contributor.authorPaneris, P
dc.contributor.authorTasoulis, M
dc.contributor.authorPelekanou, A
dc.contributor.authorBetrosian, A
dc.contributor.authorGiamarellos-Bourboulis, EJ
dc.date.accessioned2022-05-13T12:40:52Z
dc.date.available2022-05-13T12:40:52Z
dc.date.issued2008-07-18
dc.identifier.citationBMC physiology, 2008, 8 pp. 15 - ?en
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/5125
dc.identifier.eissn1472-6793en_US
dc.identifier.eissn1472-6793
dc.identifier.doi10.1186/1472-6793-8-15en_US
dc.identifier.doi10.1186/1472-6793-8-15
dc.description.abstract<h4>Background</h4>To evaluate whether the level of hypotension during hemorrhagic shock may influence the oxidative and inflammatory responses developed during post-ischemic resuscitation.<h4>Methods</h4>Fifteen rabbits were equally allocated into three groups: sham-operated (group sham); bled within 30 minutes to mean arterial pressure (MAP) of 40 mmHg (group shock-40); bled within 30 minutes to MAP of 30 mmHg (group shock-30). Shock was maintained for 60 min. Resuscitation was performed by reinfusing shed blood with two volumes of Ringer's lactate and blood was sampled for estimation of serum levels aminotransferases, creatinine, TNF-alpha, IL-1beta, IL-6, malondialdehyde (MDA) and total antioxidant status (TAS) and for the determination of oxidative burst of polymorhonuclears (PMNs) and mononuclear cells (MCs).<h4>Results</h4>Serum AST of group shock-30 was higher than that of group shock-40 at 60 and 120 minutes after start of resuscitation; serum creatinine of group shock-30 was higher than group shock-40 at 120 minutes. Measured cytokines, MDA and cellular oxidative burst of groups, shock-40 and shock-30 were higher than group sham within the first 60 minutes after start of resuscitation. Serum concentrations of IL-1beta, IL-6 and TNF-alpha of group shock-30 were higher than group shock-40 at 120 minutes (p < 0.05). No differences were found between two groups regarding serum MDA and TAS and oxidative burst on PMNs and MCs but both groups were different to group sham.<h4>Conclusion</h4>The level of hypotension is a major determinant of the severity of hepatic and renal dysfunction and of the inflammatory response arising during post-ischemic hemorrhagic shock resuscitation. These findings deserve further evaluation in the clinical setting.en_US
dc.formatElectronicen_US
dc.format.extent15 - ?en_US
dc.languageengen_US
dc.language.isoengen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectAnimalsen_US
dc.subjectRabbitsen_US
dc.subjectMyocardial Ischemiaen_US
dc.subjectHypotensionen_US
dc.subjectShock, Hemorrhagicen_US
dc.subjectCytokinesen_US
dc.subjectTreatment Outcomeen_US
dc.subjectResuscitationen_US
dc.subjectBlood Pressureen_US
dc.subjectSystemic Inflammatory Response Syndromeen_US
dc.titleThe level of hypotension during hemorrhagic shock is a major determinant of the post-resuscitation systemic inflammatory response: an experimental study.en
dc.typeJournal Article
dcterms.dateAccepted2008-07-18
rioxxterms.versionVoRen
rioxxterms.versionofrecord10.1186/1472-6793-8-15en
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en
rioxxterms.licenseref.startdate2008-07-18
dc.relation.isPartOfBMC physiologyen_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.publication-statusPublisheden_US
pubs.volume8en_US
pubs.embargo.termsNo embargoen_US
dc.contributor.icrauthorTasoulis, Mariosen_US


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