dc.contributor.author | Ben Salha, I | |
dc.contributor.author | Zaidi, S | |
dc.contributor.author | Noujaim, J | |
dc.contributor.author | Miah, AB | |
dc.contributor.author | Fisher, C | |
dc.contributor.author | Jones, RL | |
dc.contributor.author | Thway, K | |
dc.date.accessioned | 2017-03-24T14:54:04Z | |
dc.date.issued | 2016-09 | |
dc.identifier.citation | Rare tumors, 2016, 8 (3), pp. 6282 - ? | |
dc.identifier.issn | 2036-3605 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/517 | |
dc.identifier.eissn | 2036-3613 | |
dc.identifier.doi | 10.4081/rt.2016.6282 | |
dc.description.abstract | Dedifferentiated liposarcoma (DDL) is a histologically pleomorphic sarcoma, traditionally defined as well-differentiated liposarcoma with abrupt transition to high grade, non-lipogenic sarcoma. It can occur as part of recurrent well-differentiated liposarcoma, or may arise <i>de novo</i>. DDL most frequently occurs within the retroperitoneum, and while it is prone to local recurrence, it usually has a lower rate of metastasis than other pleomorphic sarcomas. We describe a case of retroperitoneal dedifferentiated liposarcoma in a 63-year-old male, who showed <i>MDM2</i> amplification with fluorescence <i>in situ</i> hybridization, which displayed unusually aggressive behavior, with brain, lung and subcutaneous soft tissue metastases. As previous reports of metastatic liposarcoma have largely grouped DDL in with other (genetically and clinically distinct) liposarcoma subtypes, we highlight and discuss the rare occurrence of brain metastasis in <i>MDM2</i>-amplified retroperitoneal liposarcoma. | |
dc.format | Electronic-eCollection | |
dc.format.extent | 6282 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.title | Rare Aggressive Behavior of <i>MDM2</i>-Amplified Retroperitoneal Dedifferentiated Liposarcoma, with Brain, Lung and Subcutaneous Metastases. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-02-25 | |
rioxxterms.versionofrecord | 10.4081/rt.2016.6282 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc/4.0 | |
rioxxterms.licenseref.startdate | 2016-09 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Rare tumors | |
pubs.issue | 3 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)/Sarcoma Clinical Trials (R Jones) (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)/Sarcoma Clinical Trials (R Jones) (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 8 | en_US |
pubs.embargo.terms | No embargo | |
icr.researchteam | Sarcoma Clinical Trials (R Jones) | en_US |
icr.researchteam | Targeted Therapy | en_US |
dc.contributor.icrauthor | Miah, Aisha | |
dc.contributor.icrauthor | Fisher, Cyril | |
dc.contributor.icrauthor | Zaidi, Shane Haider | |
dc.contributor.icrauthor | Thway, Khin | |
dc.contributor.icrauthor | Jones, Robin | |