Show simple item record

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.

dc.contributor.authorEscala-Garcia, M
dc.contributor.authorAbraham, J
dc.contributor.authorAndrulis, IL
dc.contributor.authorAnton-Culver, H
dc.contributor.authorArndt, V
dc.contributor.authorAshworth, A
dc.contributor.authorAuer, PL
dc.contributor.authorAuvinen, P
dc.contributor.authorBeckmann, MW
dc.contributor.authorBeesley, J
dc.contributor.authorBehrens, S
dc.contributor.authorBenitez, J
dc.contributor.authorBermisheva, M
dc.contributor.authorBlomqvist, C
dc.contributor.authorBlot, W
dc.contributor.authorBogdanova, NV
dc.contributor.authorBojesen, SE
dc.contributor.authorBolla, MK
dc.contributor.authorBørresen-Dale, A-L
dc.contributor.authorBrauch, H
dc.contributor.authorBrenner, H
dc.contributor.authorBrucker, SY
dc.contributor.authorBurwinkel, B
dc.contributor.authorCaldas, C
dc.contributor.authorCanzian, F
dc.contributor.authorChang-Claude, J
dc.contributor.authorChanock, SJ
dc.contributor.authorChin, S-F
dc.contributor.authorClarke, CL
dc.contributor.authorCouch, FJ
dc.contributor.authorCox, A
dc.contributor.authorCross, SS
dc.contributor.authorCzene, K
dc.contributor.authorDaly, MB
dc.contributor.authorDennis, J
dc.contributor.authorDevilee, P
dc.contributor.authorDunn, JA
dc.contributor.authorDunning, AM
dc.contributor.authorDwek, M
dc.contributor.authorEarl, HM
dc.contributor.authorEccles, DM
dc.contributor.authorEliassen, AH
dc.contributor.authorEllberg, C
dc.contributor.authorEvans, DG
dc.contributor.authorFasching, PA
dc.contributor.authorFigueroa, J
dc.contributor.authorFlyger, H
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorGapstur, SM
dc.contributor.authorGarcía-Closas, M
dc.contributor.authorGarcía-Sáenz, JA
dc.contributor.authorGaudet, MM
dc.contributor.authorGeorge, A
dc.contributor.authorGiles, GG
dc.contributor.authorGoldgar, DE
dc.contributor.authorGonzález-Neira, A
dc.contributor.authorGrip, M
dc.contributor.authorGuénel, P
dc.contributor.authorGuo, Q
dc.contributor.authorHaiman, CA
dc.contributor.authorHåkansson, N
dc.contributor.authorHamann, U
dc.contributor.authorHarrington, PA
dc.contributor.authorHiller, L
dc.contributor.authorHooning, MJ
dc.contributor.authorHopper, JL
dc.contributor.authorHowell, A
dc.contributor.authorHuang, C-S
dc.contributor.authorHuang, G
dc.contributor.authorHunter, DJ
dc.contributor.authorJakubowska, A
dc.contributor.authorJohn, EM
dc.contributor.authorKaaks, R
dc.contributor.authorKapoor, PM
dc.contributor.authorKeeman, R
dc.contributor.authorKitahara, CM
dc.contributor.authorKoppert, LB
dc.contributor.authorKraft, P
dc.contributor.authorKristensen, VN
dc.contributor.authorLambrechts, D
dc.contributor.authorLe Marchand, L
dc.contributor.authorLejbkowicz, F
dc.contributor.authorLindblom, A
dc.contributor.authorLubiński, J
dc.contributor.authorMannermaa, A
dc.contributor.authorManoochehri, M
dc.contributor.authorManoukian, S
dc.contributor.authorMargolin, S
dc.contributor.authorMartinez, ME
dc.contributor.authorMaurer, T
dc.contributor.authorMavroudis, D
dc.contributor.authorMeindl, A
dc.contributor.authorMilne, RL
dc.contributor.authorMulligan, AM
dc.contributor.authorNeuhausen, SL
dc.contributor.authorNevanlinna, H
dc.contributor.authorNewman, WG
dc.contributor.authorOlshan, AF
dc.contributor.authorOlson, JE
dc.contributor.authorOlsson, H
dc.contributor.authorOrr, N
dc.contributor.authorPeterlongo, P
dc.contributor.authorPetridis, C
dc.contributor.authorPrentice, RL
dc.contributor.authorPresneau, N
dc.contributor.authorPunie, K
dc.contributor.authorRamachandran, D
dc.contributor.authorRennert, G
dc.contributor.authorRomero, A
dc.contributor.authorSachchithananthan, M
dc.contributor.authorSaloustros, E
dc.contributor.authorSawyer, EJ
dc.contributor.authorSchmutzler, RK
dc.contributor.authorSchwentner, L
dc.contributor.authorScott, C
dc.contributor.authorSimard, J
dc.contributor.authorSohn, C
dc.contributor.authorSouthey, MC
dc.contributor.authorSwerdlow, AJ
dc.contributor.authorTamimi, RM
dc.contributor.authorTapper, WJ
dc.contributor.authorTeixeira, MR
dc.contributor.authorTerry, MB
dc.contributor.authorThorne, H
dc.contributor.authorTollenaar, RAEM
dc.contributor.authorTomlinson, I
dc.contributor.authorTroester, MA
dc.contributor.authorTruong, T
dc.contributor.authorTurnbull, C
dc.contributor.authorVachon, CM
dc.contributor.authorvan der Kolk, LE
dc.contributor.authorWang, Q
dc.contributor.authorWinqvist, R
dc.contributor.authorWolk, A
dc.contributor.authorYang, XR
dc.contributor.authorZiogas, A
dc.contributor.authorPharoah, PDP
dc.contributor.authorHall, P
dc.contributor.authorWessels, LFA
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorBader, GD
dc.contributor.authorDörk, T
dc.contributor.authorEaston, DF
dc.contributor.authorCanisius, S
dc.contributor.authorSchmidt, MK
dc.coverage.spatialEngland
dc.date.accessioned2022-09-02T12:05:41Z
dc.date.available2022-09-02T12:05:41Z
dc.date.issued2020-01-16
dc.identifierARTN 312
dc.identifier10.1038/s41467-019-14100-6
dc.identifier.citationNature Communications, 2020, 11 (1), pp. 312 -
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/5388
dc.identifier.eissn2041-1723
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/s41467-019-14100-6
dc.description.abstractIdentifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.
dc.formatElectronic
dc.format.extent312 -
dc.languageeng
dc.language.isoeng
dc.publisherNATURE PORTFOLIO
dc.relation.ispartofNature Communications
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectApoptosis
dc.subjectBreast Neoplasms
dc.subjectCircadian Clocks
dc.subjectComputational Biology
dc.subjectFemale
dc.subjectGTP-Binding Protein alpha Subunits
dc.subjectGTP-Binding Protein alpha Subunits, Gq-G11
dc.subjectGene Regulatory Networks
dc.subjectGenetic Variation
dc.subjectGenome-Wide Association Study
dc.subjectGenotype
dc.subjectGerm Cells
dc.subjectHumans
dc.subjectPrognosis
dc.subjectReceptors, Estrogen
dc.subjectSignal Transduction
dc.titleA network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
dc.typeJournal Article
dcterms.dateAccepted2019-12-17
dc.date.updated2022-09-02T11:37:06Z
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41467-019-14100-6
rioxxterms.licenseref.startdate2020-01-16
rioxxterms.typeJournal Article/Review
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/31949161
pubs.issue1
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Complex Trait Genetics
pubs.publication-statusPublished online
pubs.publisher-urlhttp://dx.doi.org/10.1038/s41467-019-14100-6
pubs.volume11
icr.researchteamComplex Trait Genetics
icr.researchteamTranslational Genetics
dc.contributor.icrauthorTurnbull, Clare
icr.provenanceDeposited by Mr Arek Surman on 2022-09-02. Deposit type is initial. No. of files: 1. Files: A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.pdf


Files in this item

Thumbnail
Name:
A network analysis to identify ...
Size:
4.149Mb
Format:
PDF
View/Open

This item appears in the following collection(s)

Show simple item record

http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/