GENCODE 2021.
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Date
2021-01-08Author
Frankish, A
Diekhans, M
Jungreis, I
Lagarde, J
Loveland, JE
Mudge, JM
Sisu, C
Wright, JC
Armstrong, J
Barnes, I
Berry, A
Bignell, A
Boix, C
Carbonell Sala, S
Cunningham, F
Di Domenico, T
Donaldson, S
Fiddes, IT
García Girón, C
Gonzalez, JM
Grego, T
Hardy, M
Hourlier, T
Howe, KL
Hunt, T
Izuogu, OG
Johnson, R
Martin, FJ
Martínez, L
Mohanan, S
Muir, P
Navarro, FCP
Parker, A
Pei, B
Pozo, F
Riera, FC
Ruffier, M
Schmitt, BM
Stapleton, E
Suner, M-M
Sycheva, I
Uszczynska-Ratajczak, B
Wolf, MY
Xu, J
Yang, YT
Yates, A
Zerbino, D
Zhang, Y
Choudhary, JS
Gerstein, M
Guigó, R
Hubbard, TJP
Kellis, M
Paten, B
Tress, ML
Flicek, P
Type
Journal Article
Metadata
Show full item recordAbstract
The GENCODE project annotates human and mouse genes and transcripts supported by experimental data with high accuracy, providing a foundational resource that supports genome biology and clinical genomics. GENCODE annotation processes make use of primary data and bioinformatic tools and analysis generated both within the consortium and externally to support the creation of transcript structures and the determination of their function. Here, we present improvements to our annotation infrastructure, bioinformatics tools, and analysis, and the advances they support in the annotation of the human and mouse genomes including: the completion of first pass manual annotation for the mouse reference genome; targeted improvements to the annotation of genes associated with SARS-CoV-2 infection; collaborative projects to achieve convergence across reference annotation databases for the annotation of human and mouse protein-coding genes; and the first GENCODE manually supervised automated annotation of lncRNAs. Our annotation is accessible via Ensembl, the UCSC Genome Browser and https://www.gencodegenes.org.
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Subject
Animals
COVID-19
Computational Biology
Databases, Genetic
Epidemics
Genomics
Humans
Internet
Mice
Molecular Sequence Annotation
Pseudogenes
RNA, Long Noncoding
SARS-CoV-2
Transcription, Genetic
Research team
Functional Proteomics
Prote & Metabolomics Fac
Language
eng
Date accepted
2020-10-24
License start date
2021-01-08
Citation
Nucleic Acids Research, 2021, 49 (D1), pp. D916 - D923
Publisher
OXFORD UNIV PRESS