dc.contributor.author | Johnston, EW | |
dc.contributor.author | Fotiadis, N | |
dc.contributor.author | Cummings, C | |
dc.contributor.author | Basso, J | |
dc.contributor.author | Tyne, T | |
dc.contributor.author | Lameijer, J | |
dc.contributor.author | Messiou, C | |
dc.contributor.author | Koh, D-M | |
dc.contributor.author | Winfield, JM | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2023-02-07T14:16:35Z | |
dc.date.available | 2023-02-07T14:16:35Z | |
dc.date.issued | 2022-11-22 | |
dc.identifier | ARTN 55 | |
dc.identifier | 10.1186/s41747-022-00308-7 | |
dc.identifier.citation | European Radiology Experimental, 2022, 6 (1), pp. 55 - | |
dc.identifier.issn | 2509-9280 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5681 | |
dc.identifier.eissn | 2509-9280 | |
dc.identifier.eissn | 2509-9280 | |
dc.identifier.doi | 10.1186/s41747-022-00308-7 | |
dc.description.abstract | BACKGROUND: Magnetic resonance imaging (MRI) can be used to target tumour components in biopsy procedures, while the ability to precisely correlate histology and MRI signal is crucial for imaging biomarker validation. Robotic MRI/computed tomography (CT) fusion biopsy offers the potential for this without in-gantry biopsy, although requires development. METHODS: Test-retest T1 and T2 relaxation times, attenuation (Hounsfield units, HU), and biopsy core quality were prospectively assessed (January-December 2021) in a range of gelatin, agar, and mixed gelatin/agar solutions of differing concentrations on days 1 and 8 after manufacture. Suitable materials were chosen, and four biopsy phantoms were constructed with twelve spherical 1-3-cm diameter targets visible on MRI, but not on CT. A technical pipeline was developed, and intraoperator and interoperator reliability was tested in four operators performing a total of 96 biopsies. Statistical analysis included T1, T2, and HU repeatability using Bland-Altman analysis, Dice similarity coefficient (DSC), and intraoperator and interoperator reliability. RESULTS: T1, T2, and HU repeatability had 95% limits-of-agreement of 8.3%, 3.4%, and 17.9%, respectively. The phantom was highly reproducible, with DSC of 0.93 versus 0.92 for scanning the same or two different phantoms, respectively. Hit rate was 100% (96/96 targets), and all operators performed robotic biopsies using a single volumetric acquisition. The fastest procedure time was 32 min for all 12 targets. CONCLUSIONS: A reproducible biopsy phantom was developed, validated, and used to test robotic MRI/CT-fusion biopsy. The technique was highly accurate, reliable, and achievable in clinically acceptable timescales meaning it is suitable for clinical application. | |
dc.format | Electronic | |
dc.format.extent | 55 - | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | SPRINGER WIEN | |
dc.relation.ispartof | European Radiology Experimental | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Image-guided biopsy | |
dc.subject | Magnetic resonance imaging | |
dc.subject | Multimodal imaging | |
dc.subject | Phantoms (imaging) | |
dc.subject | Robotics | |
dc.subject | Reproducibility of Results | |
dc.subject | Agar | |
dc.subject | Gelatin | |
dc.subject | Robotic Surgical Procedures | |
dc.subject | Image-Guided Biopsy | |
dc.subject | Magnetic Resonance Imaging | |
dc.subject | Tomography, X-Ray Computed | |
dc.title | Developing and testing a robotic MRI/CT fusion biopsy technique using a purpose-built interventional phantom. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2022-09-28 | |
dc.date.updated | 2023-02-07T13:55:36Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1186/s41747-022-00308-7 | |
rioxxterms.licenseref.startdate | 2022-11-22 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/36411379 | |
pubs.issue | 1 | |
pubs.organisational-group | /ICR | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1186/s41747-022-00308-7 | |
pubs.volume | 6 | |
icr.researchteam | Appl Phys in Clinical MRI | |
dc.contributor.icrauthor | Johnston | |
icr.provenance | Deposited by Mr Arek Surman on 2023-02-07. Deposit type is initial. No. of files: 1. Files: Developing and testing a robotic MRICT fusion biopsy technique using a purpose-built interventional phantom.pdf | |