dc.contributor.author | Taprogge, J | |
dc.contributor.author | Abreu, C | |
dc.contributor.author | Yusuf, S | |
dc.contributor.author | Ainsworth, G | |
dc.contributor.author | Phillip, RH | |
dc.contributor.author | Gear, JI | |
dc.contributor.author | Gregory, R | |
dc.contributor.author | Leek, F | |
dc.contributor.author | Murray, I | |
dc.contributor.author | Coulson, AB | |
dc.contributor.author | Brown, SR | |
dc.contributor.author | Du, Y | |
dc.contributor.author | Newbold, K | |
dc.contributor.author | Wadsley, J | |
dc.contributor.author | Flux, GD | |
dc.date.accessioned | 2023-02-09T10:08:56Z | |
dc.date.available | 2023-02-09T10:08:56Z | |
dc.date.issued | 2023-07-01 | |
dc.identifier.citation | Journal of Nuclear Medicine, | |
dc.identifier.issn | 0161-5505 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5686 | |
dc.description.abstract | Radioactive iodine is well established as a successful treatment for differentiated thyroid cancer (DTC), although around 15% of patients have local recurrence or develop distant metastases and may become refractory to radioactive iodine (RAI). A personalized approach to treatment, based on the absorbed radiation doses delivered and using treatments to enhance RAI uptake, has not yet been developed. Methods: We performed a multicenter clinical trial to investigate the role of selumetinib, which modulates the expression of the sodium iodide symporter, and hence iodine uptake, in the treatment of RAI-refractory DTC. The iodine uptake before and after selumetinib was quantified to assess the effect of selumetinib. The range of absorbed doses delivered to metastatic disease was calculated from pre- and posttherapy imaging, and the predictive accuracy of a theranostic approach to enable personalized treatment planning was investigated. Results: Significant inter- and intrapatient variability was observed with respect to the uptake of RAI and the effect of selumetinib. The absorbed doses delivered to metastatic lesions ranged from less than 1 Gy to 1,170 Gy. A strong positive correlation was found between the absorbed doses predicted from pretherapy imaging and those measured after therapy (r = 0.93, P < 0.001). Conclusion: The variation in outcomes from RAI therapy of DTC may be explained, among other factors, by the range of absorbed doses delivered. The ability to assess the effect of treatments that modulate RAI uptake, and to estimate the absorbed doses at therapy, introduces the potential for patient stratification using a theranostic approach. Patient-specific absorbed dose planning might be the key to more successful treatment of advanced DTC. | |
dc.language.iso | eng | |
dc.publisher | SOC NUCLEAR MEDICINE INC | |
dc.relation.ispartof | Journal of Nuclear Medicine | |
dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
dc.title | The Role of Pretherapy Quantitative Imaging and Dosimetry in Radioiodine Therapy for Advanced Thyroid Cancer. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2023-02-07 | |
dc.date.updated | 2023-02-09T09:28:58Z | |
rioxxterms.version | AM | |
rioxxterms.type | Journal Article/Review | |
pubs.organisational-group | /ICR | |
pubs.publication-status | Accepted | |
dc.contributor.icrauthor | Taprogge, Jan | |
icr.provenance | Deposited by Dr Jan Taprogge on 2023-02-09. Deposit type is initial. No. of files: 1. Files: Selimetry_paper_JNM_clean_Resubmission3.docx | |
icr.provenance | Deposited by Mr Arek Surman (impersonating Dr Jan Taprogge) on 2023-02-09. Deposit type is subsequent. No. of files: 1. Files: Selimetry_paper_JNM_clean_Resubmission3.pdf | |