First international workshop of the ATM and cancer risk group (4-5 December 2019).
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Date
2021-06-14Author
Lesueur, F
Easton, DF
Renault, A-L
Tavtigian, SV
Bernstein, JL
Kote-Jarai, Z
Eeles, RA
Plaseska-Karanfia, D
Feliubadaló, L
Spanish ATM working group,
Arun, B
Herold, N
Versmold, B
Schmutzler, RK
GC-HBOC,
Nguyen-Dumont, T
Southey, MC
Dorling, L
Dunning, AM
Ghiorzo, P
Dalmasso, BS
Cavaciuti, E
Le Gal, D
Roberts, NJ
Dominguez-Valentin, M
Rookus, M
Taylor, AMR
Goldstein, AM
Goldgar, DE
CARRIERS and Ambry Groups,
Stoppa-Lyonnet, D
Andrieu, N
Type
Journal Article
Metadata
Show full item recordAbstract
The first International Workshop of the ATM and Cancer Risk group focusing on the role of Ataxia-Telangiectasia Mutated (ATM) gene in cancer was held on December 4 and 5, 2019 at Institut Curie in Paris, France. It was motivated by the fact that germline ATM pathogenic variants have been found to be associated with different cancer types. However, due to the lack of precise age-, sex-, and site-specific risk estimates, no consensus on management guidelines for variant carriers exists, and the clinical utility of ATM variant testing is uncertain. The meeting brought together epidemiologists, geneticists, biologists and clinicians to review current knowledge and on-going challenges related to ATM and cancer risk. This report summarizes the meeting sessions content that covered the latest results in family-based and population-based studies, the importance of accurate variant classification, the effect of radiation exposures for ATM variant carriers, and the characteristics of ATM-deficient tumors. The report concludes that ATM variant carriers outside of the context of Ataxia-Telangiectasia may benefit from effective cancer risk management and therapeutic strategies and that efforts to set up large-scale studies in the international framework to achieve this goal are necessary.
Collections
Subject
ATM
Cancer risk
Cancer spectrum
Tumor profiles
Variants classification
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated Proteins
Breast Neoplasms
Female
France
Genetic Predisposition to Disease
Heterozygote
Humans
Neoplasms
Research team
Oncogenetics
Language
eng
Date accepted
2021-03-17
License start date
2021-06-14
Citation
Familial Cancer, 2021, 21 (2), pp. 211 - 227
Publisher
SPRINGER