dc.contributor.author | Vo, JB | |
dc.contributor.author | Ramin, C | |
dc.contributor.author | Lawrence, WR | |
dc.contributor.author | Barac, A | |
dc.contributor.author | Ho, KL | |
dc.contributor.author | Rhee, J | |
dc.contributor.author | Veiga, LHS | |
dc.contributor.author | Berrington de González, A | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2023-05-30T12:54:44Z | |
dc.date.available | 2023-05-30T12:54:44Z | |
dc.date.issued | 2023-03-01 | |
dc.identifier | 7082546 | |
dc.identifier.citation | JNCI Cancer Spectrum, 2023, 7 (2), pp. pkad024 - | |
dc.identifier.issn | 2515-5091 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5816 | |
dc.identifier.eissn | 2515-5091 | |
dc.identifier.eissn | 2515-5091 | |
dc.identifier.doi | 10.1093/jncics/pkad024 | |
dc.description.abstract | BACKGROUND: Racial and ethnic disparities in heart disease mortality by initial treatment type among breast cancer survivors have not been well described. METHODS: We included 739 557 women diagnosed with first primary invasive breast cancer between 2000 and 2017 (aged 18-84 years, received surgery, survived ≥1 year, followed through 2018) in the Surveillance, Epidemiology, and End Results-18 database. Standardized mortality ratios (SMRs; observed over expected) were calculated by race and ethnicity (non-Hispanic/Latina Asian American, Native Hawaiians, and other Pacific Islanders [AANHPI]; non-Hispanic/Latina Black [Black]; Hispanic/Latina [Latina]; and non-Hispanic/Latina White [White]) and initial treatment (surgery only; chemotherapy with surgery; chemotherapy, radiotherapy, with surgery; and radiotherapy with surgery) compared with the racial- and ethnic-matched general population, and by clinical characteristics. Cumulative heart disease mortality was estimated accounting for competing risks. RESULTS: SMRs were elevated for Black and Latina women treated with surgery only and chemotherapy with surgery (SMR range = 1.15-1.21) and AANHPI women treated with chemotherapy, radiotherapy, with surgery (SMR = 1.29; 95% confidence interval [CI] = 1.11 to 1.48), whereas SMRs were less than 1 for White women (SMR range = 0.70-0.96). SMRs were especially high for women with advanced (regional or distant) stage among Black women for all treatment (range = 1.15-2.89) and for AANHPI and Latina women treated with chemotherapy with surgery (range = 1.28-3.61). Non-White women diagnosed at younger than age 60 years had higher SMRs, as did Black and AANHPI women diagnosed with estrogen receptor-positive breast cancers. Black women had the highest 10-year cumulative risk of heart disease mortality: aged younger than 60 years (Black: 1.78%, 95% CI = 1.63% to 1.94%) compared with White, AANHPI, and Latina women (<1%) and aged 60 years and older (Black: 7.92%, 95% CI = 7.53% to 8.33%) compared with White, AANHPI, and Latina women (range = 3.90%-6.48%). CONCLUSIONS: Our findings illuminated striking racial and ethnic disparities in heart disease mortality among Black, AANHPI, and Latina breast cancer survivors, especially after initial chemotherapy receipt. | |
dc.format | Print | |
dc.format.extent | pkad024 - | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | OXFORD UNIV PRESS | |
dc.relation.ispartof | JNCI Cancer Spectrum | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Adolescent | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Middle Aged | |
dc.subject | Young Adult | |
dc.subject | Black or African American | |
dc.subject | Breast Neoplasms | |
dc.subject | Cancer Survivors | |
dc.subject | Heart Diseases | |
dc.subject | White | |
dc.subject | Hispanic or Latino | |
dc.subject | Asian American Native Hawaiian and Pacific Islander | |
dc.title | Racial and ethnic disparities in treatment-related heart disease mortality among US breast cancer survivors. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2023-03-10 | |
dc.date.updated | 2023-05-30T12:53:37Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1093/jncics/pkad024 | |
rioxxterms.licenseref.startdate | 2023-03-01 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/36943362 | |
pubs.issue | 2 | |
pubs.organisational-group | /ICR | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1093/jncics/pkad024 | |
pubs.volume | 7 | |
icr.provenance | Deposited by Mr Arek Surman on 2023-05-30. Deposit type is initial. No. of files: 1. Files: Racial and ethnic disparities in treatment-related heart disease mortality among US breast cancer survivors.pdf | |