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dc.contributor.authorMatz, Men_US
dc.contributor.authorColeman, MPen_US
dc.contributor.authorSant, Men_US
dc.contributor.authorChirlaque, MDen_US
dc.contributor.authorVisser, Oen_US
dc.contributor.authorGore, Men_US
dc.contributor.authorAllemani, Cen_US
dc.contributor.author& the CONCORD Working Groupen_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2017-04-11T14:20:40Z
dc.date.issued2017-02en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/27931752en_US
dc.identifierS0090-8258(16)31497-4en_US
dc.identifier.citationGynecol Oncol, 2017, 144 (2), pp. 405 - 413en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/583
dc.identifier.eissn1095-6859en_US
dc.identifier.doi10.1016/j.ygyno.2016.10.019en_US
dc.description.abstractOBJECTIVE: Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis. We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what role this may play in international variation in survival. METHODS: The CONCORD programme is the largest population-based study of global trends in cancer survival. Data on 681,759 women diagnosed during 1995-2009 with cancer of the ovary, fallopian tube, peritoneum and retroperitonum in 51 countries were included. We categorised ovarian tumours into six histological groups, and explored the worldwide distribution of histology. RESULTS: During 2005-2009, type II epithelial tumours were the most common. The proportion was much higher in Oceania (73.1%), North America (73.0%) and Europe (72.6%) than in Central and South America (65.7%) and Asia (56.1%). By contrast, type I epithelial tumours were more common in Asia (32.5%), compared with only 19.4% in North America. From 1995 to 2009, the proportion of type II epithelial tumours increased from 68.6% to 71.1%, while the proportion of type I epithelial tumours fell from 23.8% to 21.2%. The proportions of germ cell tumours, sex cord-stromal tumours, other specific non-epithelial tumours and tumours of non-specific morphology all remained stable over time. CONCLUSIONS: The distribution of ovarian cancer histology varies widely worldwide. Type I epithelial, germ cell and sex cord-stromal tumours are generally associated with higher survival than type II tumours, so the proportion of these tumours may influence survival estimates for all ovarian cancers combined. The distribution of histological groups should be considered when comparing survival between countries and regions.en_US
dc.format.extent405 - 413en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
dc.subjectEpidemiologyen_US
dc.subjectHistologyen_US
dc.subjectMorphologyen_US
dc.subjectOvarain canceren_US
dc.subjectWorldwideen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectCarcinoma, Ovarian Epithelialen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMiddle Ageden_US
dc.subjectNeoplasms, Germ Cell and Embryonalen_US
dc.subjectNeoplasms, Glandular and Epithelialen_US
dc.subjectOvarian Neoplasmsen_US
dc.subjectSex Cord-Gonadal Stromal Tumorsen_US
dc.titleThe histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2).en_US
dc.typeJournal Article
dcterms.dateAccepted2016-10-14en_US
rioxxterms.versionofrecord10.1016/j.ygyno.2016.10.019en_US
rioxxterms.licenseref.startdate2017-02en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfGynecol Oncolen_US
pubs.issue2en_US
pubs.notes12 monthsen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublisheden_US
pubs.volume144en_US
pubs.embargo.terms12 monthsen_US
dc.contributor.icrauthorGore, Martinen_US
dc.contributor.icrauthorMarsden,en_US


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