dc.contributor.author | Schullian, P | |
dc.contributor.author | Johnston, E | |
dc.contributor.author | Laimer, G | |
dc.contributor.author | Putzer, D | |
dc.contributor.author | Eberle, G | |
dc.contributor.author | Scharll, Y | |
dc.contributor.author | Ianetti-Hackl, C | |
dc.contributor.author | Bale, R | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2023-06-13T12:10:22Z | |
dc.date.available | 2023-06-13T12:10:22Z | |
dc.date.issued | 2021-08-01 | |
dc.identifier | 10.1007/s00270-021-02820-6 | |
dc.identifier.citation | Cardiovascular and Interventional Radiology, 2021, 44 (8), pp. 1184 - 1193 | |
dc.identifier.issn | 0174-1551 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5844 | |
dc.identifier.eissn | 1432-086X | |
dc.identifier.eissn | 1432-086X | |
dc.identifier.doi | 10.1007/s00270-021-02820-6 | |
dc.description.abstract | PURPOSE: To evaluate safety, local oncological control, long-term outcome and potential prognostic factors of stereotactic RFA (SRFA) for the treatment of BCLMs. METHODS: Between July 2003 and December 2019, 42 consecutive female patients with median age 54.0 years were treated with SRFA at our institution for 110 BCLMs in 48 ablation sessions. Median tumor size was 3.0 cm (0.8-9.0). Eighteen (42.9%) patients had extrahepatic metastasis at initial SRFA. RESULTS: Technical success rate was 100%, i.e., all coaxial needles were inserted with appropriate accuracy within 10 mm off plan and 107/110 (92.3%) BCLMs were successfully ablated at initial SRFA. Four Grade 1 (8.3%, 4/48) and one Grade 2 (2.1%, 1/48) complications occurred. No perioperative deaths occurred. Local recurrence developed in 8 of 110 tumors (7.3%). Overall survival (OS) rates of all patients at 1, 3, and 5 years from the date of the first SRFA were 84.1%, 49.3%, and 20.8% with a median OS of 32.3 months. Univariable cox regression analyses revealed age > 60 years and extrahepatic disease (without bone only metastases) as significant predictors of worse OS (p = 0.013 and 0.025, respectively). Size and number of metastases, hormone receptor status and time onset did not significantly affect OS after initial SRFA. CONCLUSIONS: SRFA is a safe, minimally invasive treatment option in the management of BCLMs, especially in younger patients without advanced extrahepatic metastasis, including those with large liver tumors. | |
dc.format | Print-Electronic | |
dc.format.extent | 1184 - 1193 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | SPRINGER | |
dc.relation.ispartof | Cardiovascular and Interventional Radiology | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Breast cancer liver metastasis | |
dc.subject | Radiofrequency ablation | |
dc.subject | Stereotaxy | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Breast Neoplasms | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Liver | |
dc.subject | Liver Neoplasms | |
dc.subject | Middle Aged | |
dc.subject | Radiofrequency Ablation | |
dc.subject | Retrospective Studies | |
dc.subject | Survival Rate | |
dc.subject | Time | |
dc.subject | Tomography, X-Ray Computed | |
dc.subject | Treatment Outcome | |
dc.title | Stereotactic Radiofrequency Ablation of Breast Cancer Liver Metastases: Short- and Long-Term Results with Predicting Factors for Survival. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2021-03-01 | |
dc.date.updated | 2023-06-08T10:51:02Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1007/s00270-021-02820-6 | |
rioxxterms.licenseref.startdate | 2021-08-01 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/33825059 | |
pubs.issue | 8 | |
pubs.organisational-group | /ICR | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1007/s00270-021-02820-6 | |
pubs.volume | 44 | |
dc.contributor.icrauthor | Johnston | |
icr.provenance | Deposited by Dr Johnston on 2023-06-08. Deposit type is initial. No. of files: 1. Files: Stereotactic Radiofrequency Ablation of Breast Cancer Liver Metastases Short- and Long-Term Results with Predicting Factors .pdf | |