dc.contributor.author | Mihalič, F | |
dc.contributor.author | Simonetti, L | |
dc.contributor.author | Giudice, G | |
dc.contributor.author | Sander, MR | |
dc.contributor.author | Lindqvist, R | |
dc.contributor.author | Peters, MBA | |
dc.contributor.author | Benz, C | |
dc.contributor.author | Kassa, E | |
dc.contributor.author | Badgujar, D | |
dc.contributor.author | Inturi, R | |
dc.contributor.author | Ali, M | |
dc.contributor.author | Krystkowiak, I | |
dc.contributor.author | Sayadi, A | |
dc.contributor.author | Andersson, E | |
dc.contributor.author | Aronsson, H | |
dc.contributor.author | Söderberg, O | |
dc.contributor.author | Dobritzsch, D | |
dc.contributor.author | Petsalaki, E | |
dc.contributor.author | Överby, AK | |
dc.contributor.author | Jemth, P | |
dc.contributor.author | Davey, NE | |
dc.contributor.author | Ivarsson, Y | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2023-08-04T13:26:09Z | |
dc.date.available | 2023-08-04T13:26:09Z | |
dc.date.issued | 2023-04-26 | |
dc.identifier | ARTN 2409 | |
dc.identifier | 10.1038/s41467-023-38015-5 | |
dc.identifier.citation | Nature Communications, 2023, 14 (1), pp. 2409 - | en_US |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5926 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.doi | 10.1038/s41467-023-38015-5 | |
dc.description.abstract | Viruses mimic host short linear motifs (SLiMs) to hijack and deregulate cellular functions. Studies of motif-mediated interactions therefore provide insight into virus-host dependencies, and reveal targets for therapeutic intervention. Here, we describe the pan-viral discovery of 1712 SLiM-based virus-host interactions using a phage peptidome tiling the intrinsically disordered protein regions of 229 RNA viruses. We find mimicry of host SLiMs to be a ubiquitous viral strategy, reveal novel host proteins hijacked by viruses, and identify cellular pathways frequently deregulated by viral motif mimicry. Using structural and biophysical analyses, we show that viral mimicry-based interactions have similar binding strength and bound conformations as endogenous interactions. Finally, we establish polyadenylate-binding protein 1 as a potential target for broad-spectrum antiviral agent development. Our platform enables rapid discovery of mechanisms of viral interference and the identification of potential therapeutic targets which can aid in combating future epidemics and pandemics. | |
dc.format | Electronic | |
dc.format.extent | 2409 - | |
dc.language | eng | |
dc.language.iso | eng | en_US |
dc.publisher | NATURE PORTFOLIO | en_US |
dc.relation.ispartof | Nature Communications | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Bacteriophages | |
dc.subject | Viruses | |
dc.subject | Intrinsically Disordered Proteins | |
dc.subject | Amino Acid Motifs | |
dc.subject | Host-Pathogen Interactions | |
dc.title | Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs. | en_US |
dc.type | Journal Article | |
dcterms.dateAccepted | 2023-04-12 | |
dc.date.updated | 2023-08-04T13:25:29Z | |
rioxxterms.version | VoR | en_US |
rioxxterms.versionofrecord | 10.1038/s41467-023-38015-5 | en_US |
rioxxterms.licenseref.startdate | 2023-04-26 | |
rioxxterms.type | Journal Article/Review | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/37100772 | |
pubs.issue | 1 | |
pubs.organisational-group | /ICR | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1038/s41467-023-38015-5 | |
pubs.volume | 14 | |
icr.researchteam | Short Linear Motif | en_US |
dc.contributor.icrauthor | Davey, Norman | |
icr.provenance | Deposited by Mr Arek Surman on 2023-08-04. Deposit type is initial. No. of files: 1. Files: Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs.pdf | |