Browsing Genetics and Epidemiology by author "Schoemaker, Minouk"
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Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women.
Schoemaker, MJ; Nichols, HB; Wright, LB; Brook, MN; Jones, ME; et al. (WILEY, 2020-09-01)Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies ... -
Association analysis identifies 65 new breast cancer risk loci.
Michailidou, K; Lindström, S; Dennis, J; Beesley, J; Hui, S; et al. (2017-11)Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. ... -
Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women.
Swerdlow, A; Schoemaker, M; Wright, L; Brook, M; Jones, M -
Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women.
Premenopausal Breast Cancer Collaborative Group,; Schoemaker, MJ; Nichols, HB; Wright, LB; Brook, MN; et al. (AMER MEDICAL ASSOC, 2018-11-01)IMPORTANCE: The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) and risk of breast cancer is unique in cancer epidemiology in that a crossover ... -
Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry.
Zhao, Z; Wen, W; Michailidou, K; Bolla, MK; Wang, Q; et al. (SPRINGER, 2016-05-01)PURPOSE: Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, whether this association is due to shared genetic factors. METHODS: We constructed a genetic ... -
Brain and Salivary Gland Tumors and Mobile Phone Use: Evaluating the Evidence from Various Epidemiological Study Designs.
Röösli, M; Lagorio, S; Schoemaker, MJ; Schüz, J; Feychting, M (ANNUAL REVIEWS, 2019-04-01)Mobile phones (MPs) are the most relevant source of radiofrequency electromagnetic field (RF-EMF) exposure to the brain and the salivary gland. Whether this exposure implies a cancer risk has been addressed in several ... -
BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer.
Shimelis, H; Mesman, RLS; Von Nicolai, C; Ehlen, A; Guidugli, L; et al. (AMER ASSOC CANCER RESEARCH, 2017-06-01)Breast cancer risks conferred by many germline missense variants in the BRCA1 and BRCA2 genes, often referred to as variants of uncertain significance (VUS), have not been established. In this study, associations between ... -
Breast Cancer Risk After Recent Childbirth: A Pooled Analysis of 15 Prospective Studies.
Nichols, HB; Schoemaker, MJ; Cai, J; Xu, J; Wright, LB; et al. (AMER COLL PHYSICIANS, 2018-12-11)BACKGROUND: Parity is widely recognized as protective for breast cancer, but breast cancer risk may be increased shortly after childbirth. Whether this risk varies with breastfeeding, family history of breast cancer, or ... -
Breast cancer risk in relation to history of preeclampsia and hyperemesis gravidarum: Prospective analysis in the Generations Study.
Wright, LB; Schoemaker, MJ; Jones, ME; Ashworth, A; Swerdlow, AJ (WILEY, 2018-08-15)Preeclampsia and hyperemesis gravidarum are pregnancy complications associated with altered sex hormone levels. Previous studies suggest preeclampsia may be associated with a decreased risk of subsequent breast cancer and ... -
Breast cancer risk prediction in women aged 35-50 years: impact of including sex hormone concentrations in the Gail model.
Clendenen, TV; Ge, W; Koenig, KL; Afanasyeva, Y; Agnoli, C; et al. (BMC, 2019-03-19)BACKGROUND: Models that accurately predict risk of breast cancer are needed to help younger women make decisions about when to begin screening. Premenopausal concentrations of circulating anti-Müllerian hormone (AMH), a ... -
Childhood body size and pubertal timing in relation to adult mammographic density phenotype.
Schoemaker, MJ; Jones, ME; Allen, S; Hoare, J; Ashworth, A; et al. (BMC, 2017-02-07)BACKGROUND: An earlier age at onset of breast development and longer time between pubertal stages has been implicated in breast cancer risk. It is not clear whether associations of breast cancer risk with puberty or ... -
Circulating anti-Müllerian hormone and breast cancer risk: A study in ten prospective cohorts.
Ge, W; Clendenen, TV; Afanasyeva, Y; Koenig, KL; Agnoli, C; et al. (WILEY, 2018-06-01)A strong positive association has been observed between circulating anti-Müllerian hormone (AMH), a biomarker of ovarian reserve, and breast cancer risk in three prospective studies. Confirming this association is important ... -
Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts.
McCullough, ML; Zoltick, ES; Weinstein, SJ; Fedirko, V; Wang, M; et al. (OXFORD UNIV PRESS INC, 2019-02-01)BACKGROUND: Experimental and epidemiological studies suggest a protective role for vitamin D in colorectal carcinogenesis, but evidence is inconclusive. Circulating 25-hydroxyvitamin D (25(OH)D) concentrations that minimize ... -
Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk.
Kapoor, PM; Mavaddat, N; Choudhury, PP; Wilcox, AN; Lindström, S; et al. (OXFORD UNIV PRESS INC, 2021-03-01)We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer ... -
Combined effects of endogenous sex hormone levels and mammographic density on postmenopausal breast cancer risk: results from the Breakthrough Generations Study.
Schoemaker, MJ; Folkerd, EJ; Jones, ME; Rae, M; Allen, S; et al. (NATURE PUBLISHING GROUP, 2014-04-02)BACKGROUND: Mammographic density and sex hormone levels are strong risk factors for breast cancer, but it is unclear whether they represent the same aetiological entity or are independent risk factors. METHODS: Within the ... -
Common variants in breast cancer risk loci predispose to distinct tumor subtypes.
Ahearn, TU; Zhang, H; Michailidou, K; Milne, RL; Bolla, MK; et al. (BMC, 2022-01-04)BACKGROUND: Genome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these ... -
Comparative performance of lung cancer risk models to define lung screening eligibility in the United Kingdom.
Robbins, HA; Alcala, K; Swerdlow, AJ; Schoemaker, MJ; Wareham, N; et al. (SPRINGERNATURE, 2021-06-08)BACKGROUND: The National Health Service England (NHS) classifies individuals as eligible for lung cancer screening using two risk prediction models, PLCOm2012 and Liverpool Lung Project-v2 (LLPv2). However, no study has ... -
Comparative Validation of Breast Cancer Risk Prediction Models and Projections for Future Risk Stratification.
Pal Choudhury, P; Wilcox, AN; Brook, MN; Zhang, Y; Ahearn, T; et al. (OXFORD UNIV PRESS INC, 2020-03-01)BACKGROUND: External validation of risk models is critical for risk-stratified breast cancer prevention. We used the Individualized Coherent Absolute Risk Estimation (iCARE) as a flexible tool for risk model development ... -
Comparative validation of the BOADICEA and Tyrer-Cuzick breast cancer risk models incorporating classical risk factors and polygenic risk in a population-based prospective cohort of women of European ancestry.
Pal Choudhury, P; Brook, MN; Hurson, AN; Lee, A; Mulder, CV; et al. (BMC, 2021-02-15)BACKGROUND: The Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) and the Tyrer-Cuzick breast cancer risk prediction models are commonly used in clinical practice and have recently ... -
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers.
Johnson, N; Maguire, S; Morra, A; Kapoor, PM; Tomczyk, K; et al. (SPRINGERNATURE, 2021-02-16)BACKGROUND: Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary ...