Browsing Genetics and Epidemiology by author "Jones, Michael"
Now showing items 1-20 of 72
-
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers.
Coignard, J; Lush, M; Beesley, J; O'Mara, TA; Dennis, J; et al. (NATURE PORTFOLIO, 2021-02-17)Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in ... -
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.
Wu, L; Shi, W; Long, J; Guo, X; Michailidou, K; et al. (NATURE PORTFOLIO, 2018-07-01)The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify ... -
Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women.
Schoemaker, MJ; Nichols, HB; Wright, LB; Brook, MN; Jones, ME; et al. (WILEY, 2020-09-01)Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies ... -
Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers.
Schmidt, MK; Hogervorst, F; van Hien, R; Cornelissen, S; Broeks, A; et al. (LIPPINCOTT WILLIAMS & WILKINS, 2016-08-10)PURPOSE: CHEK2*1100delC is a well-established breast cancer risk variant that is most prevalent in European populations; however, there are limited data on risk of breast cancer by age and tumor subtype, which limits its ... -
Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry.
Mueller, SH; Lai, AG; Valkovskaya, M; Michailidou, K; Bolla, MK; et al. (BMC, 2023-01-26)BACKGROUND: Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes. METHODS: ... -
Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium.
Trabert, B; Poole, EM; White, E; Visvanathan, K; Adami, H-O; et al. (OXFORD UNIV PRESS INC, 2019-02-01)BACKGROUND: Aspirin use is associated with reduced risk of several cancers. A pooled analysis of 12 case-control studies showed a 10% decrease in ovarian cancer risk with regular aspirin use, which was stronger for daily ... -
Association analysis identifies 65 new breast cancer risk loci.
Michailidou, K; Lindström, S; Dennis, J; Beesley, J; Hui, S; et al. (2017-11)Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. ... -
Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women.
Premenopausal Breast Cancer Collaborative Group,; Schoemaker, MJ; Nichols, HB; Wright, LB; Brook, MN; et al. (AMER MEDICAL ASSOC, 2018-11-01)IMPORTANCE: The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) and risk of breast cancer is unique in cancer epidemiology in that a crossover ... -
Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.
Hamdi, Y; Soucy, P; Adoue, V; Michailidou, K; Canisius, S; et al. (IMPACT JOURNALS LLC, 2016-12-06)There are significant inter-individual differences in the levels of gene expression. Through modulation of gene expression, cis-acting variants represent an important source of phenotypic variation. Consequently, cis-regulatory ... -
Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study.
Rambau, PF; Vierkant, RA; Intermaggio, MP; Kelemen, LE; Goodman, MT; et al. (WILEY, 2018-10-01)We aimed to validate the prognostic association of p16 expression in ovarian high-grade serous carcinomas (HGSC) and to explore it in other ovarian carcinoma histotypes. p16 protein expression was assessed by clinical-grade ... -
Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival.
Morra, A; Schreurs, MAC; Andrulis, IL; Anton-Culver, H; Augustinsson, A; et al. (WILEY, 2023-08-01)BACKGROUND: Breast cancer (BC) patients with a germline CHEK2 c.1100delC variant have an increased risk of contralateral BC (CBC) and worse BC-specific survival (BCSS) compared to non-carriers. AIM: To assessed the ... -
Breast Cancer Risk After Recent Childbirth: A Pooled Analysis of 15 Prospective Studies.
Nichols, HB; Schoemaker, MJ; Cai, J; Xu, J; Wright, LB; et al. (AMER COLL PHYSICIANS, 2018-12-11)BACKGROUND: Parity is widely recognized as protective for breast cancer, but breast cancer risk may be increased shortly after childbirth. Whether this risk varies with breastfeeding, family history of breast cancer, or ... -
Breast cancer risk following Hodgkin lymphoma radiotherapy in relation to menstrual and reproductive factors.
Cooke, R; Jones, ME; Cunningham, D; Falk, SJ; Gilson, D; et al. (NATURE PUBLISHING GROUP, 2013-06-11)BACKGROUND: Women treated with supradiaphragmatic radiotherapy (sRT) for Hodgkin lymphoma (HL) at young ages have a substantially increased breast cancer risk. Little is known about how menarcheal and reproductive factors ... -
Breast cancer risk in relation to history of preeclampsia and hyperemesis gravidarum: Prospective analysis in the Generations Study.
Wright, LB; Schoemaker, MJ; Jones, ME; Ashworth, A; Swerdlow, AJ (WILEY, 2018-08-15)Preeclampsia and hyperemesis gravidarum are pregnancy complications associated with altered sex hormone levels. Previous studies suggest preeclampsia may be associated with a decreased risk of subsequent breast cancer and ... -
Cancer incidence and mortality in 23 000 patients with type 1 diabetes in the UK: Long-term follow-up.
Swerdlow, AJ; Jones, ME; Slater, SD; Burden, ACF; Botha, JL; et al. (WILEY, 2023-08-01)Type 2 diabetes is associated with raised risk of several cancers, but for type 1 diabetes risk data are fewer and inconsistent We assembled a cohort of 23 473 UK patients with insulin-treated diabetes diagnosed at ages ... -
Childhood body size and pubertal timing in relation to adult mammographic density phenotype.
Schoemaker, MJ; Jones, ME; Allen, S; Hoare, J; Ashworth, A; et al. (BMC, 2017-02-07)BACKGROUND: An earlier age at onset of breast development and longer time between pubertal stages has been implicated in breast cancer risk. It is not clear whether associations of breast cancer risk with puberty or ... -
Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts.
McCullough, ML; Zoltick, ES; Weinstein, SJ; Fedirko, V; Wang, M; et al. (OXFORD UNIV PRESS INC, 2019-02-01)BACKGROUND: Experimental and epidemiological studies suggest a protective role for vitamin D in colorectal carcinogenesis, but evidence is inconclusive. Circulating 25-hydroxyvitamin D (25(OH)D) concentrations that minimize ... -
Collateral damage: the impact on outcomes from cancer surgery of the COVID-19 pandemic.
Sud, A; Jones, ME; Broggio, J; Loveday, C; Torr, B; et al. (ELSEVIER, 2020-08-01)BACKGROUND: Cancer diagnostics and surgery have been disrupted by the response of health care services to the coronavirus disease 2019 (COVID-19) pandemic. Progression of cancers during delay will impact on patients' ... -
Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk.
Kapoor, PM; Mavaddat, N; Choudhury, PP; Wilcox, AN; Lindström, S; et al. (OXFORD UNIV PRESS INC, 2021-03-01)We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer ... -
Combined effects of endogenous sex hormone levels and mammographic density on postmenopausal breast cancer risk: results from the Breakthrough Generations Study.
Schoemaker, MJ; Folkerd, EJ; Jones, ME; Rae, M; Allen, S; et al. (NATURE PUBLISHING GROUP, 2014-04-02)BACKGROUND: Mammographic density and sex hormone levels are strong risk factors for breast cancer, but it is unclear whether they represent the same aetiological entity or are independent risk factors. METHODS: Within the ...