dc.contributor.author | Allen, I | |
dc.contributor.author | Hassan, H | |
dc.contributor.author | Joko-Fru, WY | |
dc.contributor.author | Huntley, C | |
dc.contributor.author | Loong, L | |
dc.contributor.author | Rahman, T | |
dc.contributor.author | Torr, B | |
dc.contributor.author | Bacon, A | |
dc.contributor.author | Knott, C | |
dc.contributor.author | Jose, S | |
dc.contributor.author | Vernon, S | |
dc.contributor.author | Lüchtenborg, M | |
dc.contributor.author | Pethick, J | |
dc.contributor.author | Lavelle, K | |
dc.contributor.author | McRonald, F | |
dc.contributor.author | Eccles, D | |
dc.contributor.author | Morris, EJA | |
dc.contributor.author | Hardy, S | |
dc.contributor.author | Turnbull, C | |
dc.contributor.author | Tischkowitz, M | |
dc.contributor.author | Pharoah, P | |
dc.contributor.author | Antoniou, AC | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2024-07-10T08:24:46Z | |
dc.date.available | 2024-07-10T08:24:46Z | |
dc.date.issued | 2024-05-01 | |
dc.identifier | ARTN 100903 | |
dc.identifier | S2666-7762(24)00069-3 | |
dc.identifier.citation | The Lancet Regional Health - Europe, 2024, 40 pp. 100903 - | en_US |
dc.identifier.issn | 2666-7762 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/6302 | |
dc.identifier.eissn | 2666-7762 | |
dc.identifier.eissn | 2666-7762 | |
dc.identifier.doi | 10.1016/j.lanepe.2024.100903 | |
dc.identifier.doi | 10.1016/j.lanepe.2024.100903 | |
dc.description.abstract | BACKGROUND: Second primary cancers (SPCs) after breast cancer (BC) present an increasing public health burden, with little existing research on socio-demographic, tumour, and treatment effects. We addressed this in the largest BC survivor cohort to date, using a novel linkage of National Disease Registration Service datasets. METHODS: The cohort included 581,403 female and 3562 male BC survivors diagnosed between 1995 and 2019. We estimated standardized incidence ratios (SIRs) for combined and site-specific SPCs using incidences for England, overall and by age at BC and socioeconomic status. We estimated incidences and Kaplan-Meier cumulative risks stratified by age at BC, and assessed risk variation by socio-demographic, tumour, and treatment characteristics using Cox regression. FINDINGS: Both genders were at elevated contralateral breast (SIR: 2.02 (95% CI: 1.99-2.06) females; 55.4 (35.5-82.4) males) and non-breast (1.10 (1.09-1.11) females, 1.10 (1.00-1.20) males) SPC risks. Non-breast SPC risks were higher for females younger at BC diagnosis (SIR: 1.34 (1.31-1.38) <50 y, 1.07 (1.06-1.09) ≥50 y) and more socioeconomically deprived (SIR: 1.00 (0.98-1.02) least deprived quintile, 1.34 (1.30-1.37) most). INTERPRETATION: Enhanced SPC surveillance may benefit BC survivors, although specific recommendations require more detailed multifactorial risk and cost-benefit analyses. The associations between deprivation and SPC risks could provide clinical management insights. FUNDING: CRUK Catalyst Award CanGene-CanVar (C61296/A27223). Cancer Research UK grant: PPRPGM-Nov 20∖100,002. This work was supported by core funding from the NIHR Cambridge Biomedical Research Centre (NIHR203312)]. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. | |
dc.format | Electronic-eCollection | |
dc.format.extent | 100903 - | |
dc.language | eng | |
dc.language.iso | eng | en_US |
dc.publisher | ELSEVIER | en_US |
dc.relation.ispartof | The Lancet Regional Health - Europe | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Breast cancer | |
dc.subject | Deprivation | |
dc.subject | Epidemiology | |
dc.subject | Incidence | |
dc.subject | Pathology | |
dc.subject | Risk | |
dc.subject | Second primary cancer | |
dc.subject | Treatment | |
dc.title | Risks of second primary cancers among 584,965 female and male breast cancer survivors in England: a 25-year retrospective cohort study. | en_US |
dc.type | Journal Article | |
dcterms.dateAccepted | 2024-03-28 | |
dc.date.updated | 2024-07-09T08:15:36Z | |
rioxxterms.version | VoR | en_US |
rioxxterms.versionofrecord | 10.1016/j.lanepe.2024.100903 | en_US |
rioxxterms.licenseref.startdate | 2024-05-01 | |
rioxxterms.type | Journal Article/Review | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38745989 | |
pubs.organisational-group | ICR | |
pubs.organisational-group | ICR/Students | |
pubs.organisational-group | ICR/Students/PhD and MPhil | |
pubs.organisational-group | ICR/Students/PhD and MPhil/20/21 Starting Cohort | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1016/j.lanepe.2024.100903 | |
pubs.volume | 40 | |
icr.researchteam | Translational Genetics | en_US |
dc.contributor.icrauthor | Pronin, Lucy Wai Yee | |
icr.provenance | Deposited by Dr Lucy Pronin on 2024-07-09. Deposit type is initial. No. of files: 1. Files: Risks of second primary cancers among 584,965 female and male breast cancer survivors in England a 25-year retrospective coh.pdf | |