dc.contributor.author | Sammut, S-J | |
dc.contributor.author | Galson, JD | |
dc.contributor.author | Minter, R | |
dc.contributor.author | Sun, B | |
dc.contributor.author | Chin, S-F | |
dc.contributor.author | De Mattos-Arruda, L | |
dc.contributor.author | Finch, DK | |
dc.contributor.author | Schätzle, S | |
dc.contributor.author | Dias, J | |
dc.contributor.author | Rueda, OM | |
dc.contributor.author | Seoane, J | |
dc.contributor.author | Osbourn, J | |
dc.contributor.author | Caldas, C | |
dc.contributor.author | Bashford-Rogers, RJM | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2024-07-23T10:39:44Z | |
dc.date.available | 2024-07-23T10:39:44Z | |
dc.date.issued | 2024-05-01 | |
dc.identifier | 10.1038/s41590-024-01821-0 | |
dc.identifier.citation | Nature Immunology, 2024, 25 (5), pp. 916 - 924 | en_US |
dc.identifier.issn | 1529-2908 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/6312 | |
dc.identifier.eissn | 1529-2916 | |
dc.identifier.eissn | 1529-2916 | |
dc.identifier.doi | 10.1038/s41590-024-01821-0 | |
dc.identifier.doi | 10.1038/s41590-024-01821-0 | |
dc.description.abstract | B cells and T cells are important components of the adaptive immune system and mediate anticancer immunity. The T cell landscape in cancer is well characterized, but the contribution of B cells to anticancer immunosurveillance is less well explored. Here we show an integrative analysis of the B cell and T cell receptor repertoire from individuals with metastatic breast cancer and individuals with early breast cancer during neoadjuvant therapy. Using immune receptor, RNA and whole-exome sequencing, we show that both B cell and T cell responses seem to coevolve with the metastatic cancer genomes and mirror tumor mutational and neoantigen architecture. B cell clones associated with metastatic immunosurveillance and temporal persistence were more expanded and distinct from site-specific clones. B cell clonal immunosurveillance and temporal persistence are predictable from the clonal structure, with higher-centrality B cell antigen receptors more likely to be detected across multiple metastases or across time. This predictability was generalizable across other immune-mediated disorders. This work lays a foundation for prioritizing antibody sequences for therapeutic targeting in cancer. | |
dc.format | Print-Electronic | |
dc.format.extent | 916 - 924 | |
dc.language | eng | |
dc.language.iso | eng | en_US |
dc.publisher | NATURE PORTFOLIO | en_US |
dc.relation.ispartof | Nature Immunology | |
dc.subject | Humans | |
dc.subject | Female | |
dc.subject | Breast Neoplasms | |
dc.subject | B-Lymphocytes | |
dc.subject | Immunologic Surveillance | |
dc.subject | Receptors, Antigen, T-Cell | |
dc.subject | Receptors, Antigen, B-Cell | |
dc.subject | T-Lymphocytes | |
dc.subject | Monitoring, Immunologic | |
dc.subject | Exome Sequencing | |
dc.subject | Antigens, Neoplasm | |
dc.subject | Neoplasm Metastasis | |
dc.subject | Clone Cells | |
dc.title | Predictability of B cell clonal persistence and immunosurveillance in breast cancer. | en_US |
dc.type | Journal Article | |
dcterms.dateAccepted | 2024-03-15 | |
dc.date.updated | 2024-07-23T07:35:28Z | |
rioxxterms.version | AM | en_US |
rioxxterms.versionofrecord | 10.1038/s41590-024-01821-0 | en_US |
rioxxterms.licenseref.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
rioxxterms.licenseref.startdate | 2024-05-01 | |
rioxxterms.type | Journal Article/Review | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38698238 | |
pubs.issue | 5 | |
pubs.organisational-group | ICR | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1038/s41590-024-01821-0 | |
pubs.volume | 25 | |
icr.researchteam | Cancer Dynamics | en_US |
dc.contributor.icrauthor | Sammut, Stephen John | |
icr.provenance | Deposited by Dr Stephen-John Sammut on 2024-07-23. Deposit type is initial. No. of files: 1. Files: Predictability of B cell clonal persistence and immunosurveillance in breast cancer.pdf | |
icr.provenance | Deposited by Mr Arek Surman on 2024-07-30. Deposit type is subsequent. No. of files: 1. Files: Predictability of B cell clonal persistence and immunosurveillance in breast cancer.pdf | |