dc.contributor.author | Bancroft, EK | |
dc.contributor.author | Page, EC | |
dc.contributor.author | Brook, MN | |
dc.contributor.author | Pope, J | |
dc.contributor.author | Thomas, S | |
dc.contributor.author | Myhill, K | |
dc.contributor.author | Helfand, BT | |
dc.contributor.author | Talaty, P | |
dc.contributor.author | Ong, K-R | |
dc.contributor.author | Douglas, E | |
dc.contributor.author | Cook, J | |
dc.contributor.author | Rosario, DJ | |
dc.contributor.author | Salinas, M | |
dc.contributor.author | Buys, SS | |
dc.contributor.author | Anson, J | |
dc.contributor.author | Davidson, R | |
dc.contributor.author | Longmuir, M | |
dc.contributor.author | Side, L | |
dc.contributor.author | Eccles, DM | |
dc.contributor.author | Tischkowitz, M | |
dc.contributor.author | Taylor, A | |
dc.contributor.author | Cruellas, M | |
dc.contributor.author | Ballestero, EP | |
dc.contributor.author | Cleaver, R | |
dc.contributor.author | Varughese, M | |
dc.contributor.author | Barwell, J | |
dc.contributor.author | LeButt, M | |
dc.contributor.author | Greenhalgh, L | |
dc.contributor.author | Hart, R | |
dc.contributor.author | Azzabi, A | |
dc.contributor.author | Jobson, I | |
dc.contributor.author | Cogley, L | |
dc.contributor.author | Evans, DG | |
dc.contributor.author | Rothwell, J | |
dc.contributor.author | Taylor, N | |
dc.contributor.author | Hogben, M | |
dc.contributor.author | Saya, S | |
dc.contributor.author | IMPACT Study Steering Committee; IMPACT Collaborators, | |
dc.contributor.author | Eeles, RA | |
dc.contributor.author | Aaronson, NK | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2024-07-25T15:14:06Z | |
dc.date.available | 2024-07-25T15:14:06Z | |
dc.date.issued | 2024-06-05 | |
dc.identifier.citation | BJU International, 2024, | |
dc.identifier.issn | 1464-4096 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/6317 | |
dc.identifier.eissn | 1464-410X | |
dc.identifier.eissn | 1464-410X | |
dc.identifier.doi | 10.1111/bju.16432 | |
dc.identifier.doi | 10.1111/bju.16432 | |
dc.description.abstract | OBJECTIVES: To report the long-term outcomes from a longitudinal psychosocial study that forms part of the 'Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted Screening in men at higher genetic risk and controls' (IMPACT) study. The IMPACT study is a multi-national study of targeted prostate cancer (PrCa) screening in individuals with a known germline pathogenic variant (GPV) in either the BReast CAncer gene 1 (BRCA1) or the BReast CAncer gene 2 (BRCA2). SUBJECTS AND METHODS: Participants enrolled in the IMPACT study were invited to complete a psychosocial questionnaire prior to each annual screening visit for a minimum of 5 years. The questionnaire included questions on sociodemographics and the following measures: Hospital Anxiety and Depression Scale, Impact of Event Scale, 36-item Short-Form Health Survey, Memorial Anxiety Scale for PrCa, Cancer Worry Scale, risk perception and knowledge. RESULTS: A total of 760 participants completed questionnaires: 207 participants with GPV in BRCA1, 265 with GPV in BRCA2 and 288 controls (non-carriers from families with a known GPV). We found no evidence of clinically concerning levels of general or cancer-specific distress or poor health-related quality of life in the cohort as a whole. Individuals in the control group had significantly less worry about PrCa compared with the carriers; however, all mean scores were low and within reported general population norms, where available. BRCA2 carriers with previously high prostate-specific antigen (PSA) levels experience a small but significant increase in PrCa anxiety (P = 0.01) and PSA-specific anxiety (P < 0.001). Cancer risk perceptions reflected information provided during genetic counselling and participants had good levels of knowledge, although this declined over time. CONCLUSION: This is the first study to report the longitudinal psychosocial impact of a targeted PrCa screening programme for BRCA1 and BRCA2 carriers. The results reassure that an annual PSA-based screening programme does not have an adverse impact on psychosocial health or health-related quality of life in these higher-risk individuals. These results are important as more PrCa screening is targeted to higher-risk groups. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | WILEY | |
dc.relation.ispartof | BJU International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | BRCA1 | |
dc.subject | BRCA2 | |
dc.subject | genetic screening | |
dc.subject | prostate cancer | |
dc.subject | psychosocial | |
dc.subject | quality of life | |
dc.title | The psychosocial impact of prostate cancer screening for BRCA1 and BRCA2 carriers. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2024-06-05 | |
dc.date.updated | 2024-07-23T13:13:23Z | |
rioxxterms.version | AM | |
rioxxterms.versionofrecord | 10.1111/bju.16432 | |
rioxxterms.licenseref.startdate | 2024-06-05 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38839570 | |
pubs.organisational-group | ICR | |
pubs.organisational-group | ICR/Primary Group | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1111/bju.16432 | |
icr.researchteam | Oncogenetics | |
dc.contributor.icrauthor | Brook, Mark | |
dc.contributor.icrauthor | Eeles, Rosalind | |
icr.provenance | Deposited by Miss Fay Allen (impersonating Prof Ros Eeles) on 2024-07-23. Deposit type is initial. No. of files: 1. Files: IMPACT QoL Manuscript Revised 23.4.24.CLEAN.docx | |