The Role of Hypofractionated Radiotherapy in Prostate Cancer.
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Date
2017-04-01ICR Author
Author
Benjamin, LC
Tree, AC
Dearnaley, DP
Type
Journal Article
Metadata
Show full item recordAbstract
PURPOSE OF REVIEW: It is now accepted that prostate cancer has a low alpha/beta ratio, establishing a strong basis for hypofractionation of prostate radiotherapy. This review focuses on the rationale for hypofractionation and presents the evidence base for establishing moderate hypofractionation for localised disease as the new standard of care. The emerging evidence for extreme hypofractionation in managing localized and oligometastatic prostate cancer is reviewed. RECENT FINDINGS: The 5-year efficacy and toxicity outcomes from four phase III studies have been published within the last 12 months. These studies randomizing over 6000 patients to conventional fractionation (1.8-2.0 Gy per fraction) or moderate hypofractionation (3.0-3.4 Gy per fraction). They demonstrate hypofractionation to be non-inferior to conventional fractionation. Moderate hypofractionation for localized prostate cancer is safe and effective. There is a growing body of evidence in support of extreme hypofractionation for localized prostate cancer. Extreme hypofractionation may have a role in managing prostate oligometastases, but further studies are needed.
Collections
Subject
Humans
Prostatic Neoplasms
Treatment Outcome
Male
Radiotherapy, Intensity-Modulated
Radiation Dose Hypofractionation
Research team
Clinical Academic Radiotherapy (Dearnaley)
Language
eng
Date accepted
2017-03-25
License start date
2017-04
Citation
Current oncology reports, 2017, 19 (4), pp. 30 - ?
Publisher
SPRINGER