Now showing items 21-40 of 1090

    • A Dosimetric Comparison of Breast Radiotherapy Techniques to Treat Locoregional Lymph Nodes Including the Internal Mammary Chain. 

      Ranger, A; Dunlop, A; Hutchinson, K; Convery, H; Maclennan, MK; Chantler, H; Twyman, N; Rose, C; McQuaid, D; Amos, RA; Griffin, C; deSouza, NM; Donovan, E; Harris, E; Coles, CE; Kirby, A (2018-06)
      Aims Radiotherapy target volumes in early breast cancer treatment increasingly include the internal mammary chain (IMC). In order to maximise survival benefits of IMC radiotherapy, doses to the heart and lung should be ...
    • A dosimetric comparison of real-time adaptive and non-adaptive radiotherapy: A multi-institutional study encompassing robotic, gimbaled, multileaf collimator and couch tracking. 

      Colvill, E; Booth, J; Nill, S; Fast, M; Bedford, J; Oelfke, U; Nakamura, M; Poulsen, P; Worm, E; Hansen, R; Ravkilde, T; Scherman Rydhög, J; Pommer, T; Munck Af Rosenschold, P; Lang, S; Guckenberger, M; Groh, C; Herrmann, C; Verellen, D; Poels, K; Wang, L; Hadsell, M; Sothmann, T; Blanck, O; Keall, P (2016-04)
      Purpose A study of real-time adaptive radiotherapy systems was performed to test the hypothesis that, across delivery systems and institutions, the dosimetric accuracy is improved with adaptive treatments over non-adaptive ...
    • A generalized framework unifying image registration and respiratory motion models and incorporating image reconstruction, for partial image data or full images. 

      McClelland, JR; Modat, M; Arridge, S; Grimes, H; D'Souza, D; Thomas, D; Connell, DO; Low, DA; Kaza, E; Collins, DJ; Leach, MO; Hawkes, DJ (2017-06)
      Surrogate-driven respiratory motion models relate the motion of the internal anatomy to easily acquired respiratory surrogate signals, such as the motion of the skin surface. They are usually built by first using image ...
    • A Genetic Risk Score to Personalize Prostate Cancer Screening, Applied to Population Data. 

      Huynh-Le, M-P; Fan, CC; Karunamuni, R; Walsh, EI; Turner, EL; Lane, JA; Martin, RM; Neal, DE; Donovan, JL; Hamdy, FC; Parsons, JK; Eeles, RA; Easton, DF; Kote-Jarai, Z; Amin Al Olama, A; Benlloch Garcia, S; Muir, K; Grönberg, H; Wiklund, F; Aly, M; Schleutker, J; Sipeky, C; Tammela, TL; Nordestgaard, BG; Key, TJ; Travis, RC; Pharoah, PDP; Pashayan, N; Khaw, K-T; Thibodeau, SN; McDonnell, SK; Schaid, DJ; Maier, C; Vogel, W; Luedeke, M; Herkommer, K; Kibel, AS; Cybulski, C; Wokolorczyk, D; Kluzniak, W; Cannon-Albright, LA; Brenner, H; Schöttker, B; Holleczek, B; Park, JY; Sellers, TA; Lin, H-Y; Slavov, CK; Kaneva, RP; Mitev, VI; Batra, J; Clements, JA; Spurdle, AB; Teixeira, MR; Paulo, P; Maia, S; Pandha, H; Michael, A; Mills, IG; Andreassen, OA; Dale, AM; Seibert, TM; Australian Prostate Cancer BioResource (APCB); PRACTICAL Consortium (2020-09)
      Background A polygenic hazard score (PHS), the weighted sum of 54 SNP genotypes, was previously validated for association with clinically significant prostate cancer and for improved prostate cancer screening accuracy. ...
    • A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population. 

      Marzec, J; Mao, X; Li, M; Wang, M; Feng, N; Gou, X; Wang, G; Sun, Z; Xu, J; Xu, H; Zhang, X; Zhao, S-C; Ren, G; Yu, Y; Wu, Y; Wu, J; Xue, Y; Zhou, B; Zhang, Y; Xu, X; Li, J; He, W; Benlloch, S; Ross-Adams, H; Chen, L; Li, J; Hong, Y; Kote-Jarai, Z; Cui, X; Hou, J; Guo, J; Xu, L; Yin, C; Zhou, Y; Neal, DE; Oliver, T; Cao, G; Zhang, Z; Easton, DF; Chelala, C; PRACTICAL Consortium; CHIPGECS Group; Al Olama, AA; Eeles, RA; Zhang, H; Lu, Y-J (2016-04)
      Prostate cancer predisposition has been extensively investigated in European populations, but there have been few studies of other ethnic groups. To investigate prostate cancer susceptibility in the under-investigated ...
    • A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease. 

      Scott, RA; Freitag, DF; Li, L; Chu, AY; Surendran, P; Young, R; Grarup, N; Stancáková, A; Chen, Y; Varga, TV; Yaghootkar, H; Luan, J; Zhao, JH; Willems, SM; Wessel, J; Wang, S; Maruthur, N; Michailidou, K; Pirie, A; van der Lee, SJ; Gillson, C; Al Olama, AA; Amouyel, P; Arriola, L; Arveiler, D; Aviles-Olmos, I; Balkau, B; Barricarte, A; Barroso, I; Garcia, SB; Bis, JC; Blankenberg, S; Boehnke, M; Boeing, H; Boerwinkle, E; Borecki, IB; Bork-Jensen, J; Bowden, S; Caldas, C; Caslake, M; CVD50 consortium; Cupples, LA; Cruchaga, C; Czajkowski, J; den Hoed, M; Dunn, JA; Earl, HM; Ehret, GB; Ferrannini, E; Ferrieres, J; Foltynie, T; Ford, I; Forouhi, NG; Gianfagna, F; Gonzalez, C; Grioni, S; Hiller, L; Jansson, J-H; Jørgensen, ME; Jukema, JW; Kaaks, R; Kee, F; Kerrison, ND; Key, TJ; Kontto, J; Kote-Jarai, Z; Kraja, AT; Kuulasmaa, K; Kuusisto, J; Linneberg, A; Liu, C; Marenne, G; Mohlke, KL; Morris, AP; Muir, K; Müller-Nurasyid, M; Munroe, PB; Navarro, C; Nielsen, SF; Nilsson, PM; Nordestgaard, BG; Packard, CJ; Palli, D; Panico, S; Peloso, GM; Perola, M; Peters, A; Poole, CJ; Quirós, JR; Rolandsson, O; Sacerdote, C; Salomaa, V; Sánchez, M-J; Sattar, N; Sharp, SJ; Sims, R; Slimani, N; Smith, JA; Thompson, DJ; Trompet, S; Tumino, R; van der A, DL; van der Schouw, YT; Virtamo, J; Walker, M; Walter, K; GERAD_EC Consortium; Neurology Working Group of the Cohorts for Heart; Aging Research in Genomic Epidemiology (CHARGE); Alzheimer’s Disease Genetics Consortium; Pancreatic Cancer Cohort Consortium; European Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD); EPIC-InterAct; Abraham, JE; Amundadottir, LT; Aponte, JL; Butterworth, AS; Dupuis, J; Easton, DF; Eeles, RA; Erdmann, J; Franks, PW; Frayling, TM; Hansen, T; Howson, JMM; Jørgensen, T; Kooner, J; Laakso, M; Langenberg, C; McCarthy, MI; Pankow, JS; Pedersen, O; Riboli, E; Rotter, JI; Saleheen, D; Samani, NJ; Schunkert, H; Vollenweider, P; O'Rahilly, S; CHARGE consortium; CHD Exome+ Consortium; CARDIOGRAM Exome Consortium; Deloukas, P; Danesh, J; Goodarzi, MO; Kathiresan, S; Meigs, JB; Ehm, MG; Wareham, NJ; Waterworth, DM (2016-06)
      Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic ...
    • A kernel-based dose calculation algorithm for kV photon beams with explicit handling of energy and material dependencies. 

      Reinhart, AM; Fast, MF; Ziegenhein, P; Nill, S; Oelfke, U (2017-01)
      Objective Mimicking state-of-the-art patient radiotherapy with high-precision irradiators for small animals is expected to advance the understanding of dose-effect relationships and radiobiology in general. We work on the ...
    • A Monte Carlo study of the effect of an ultrasound transducer on surface dose during intrafraction motion imaging for external beam radiation therapy. 

      Martyn, M; O'Shea, TP; Harris, E; Bamber, J; Gilroy, S; Foley, MJ (2017-10)
      Purpose The aim of this study was to estimate changes in surface dose due to the presence of the Clarity Autoscan™ ultrasound (US) probe during prostate radiotherapy using Monte Carlo (MC) methods.Methods MC models of the ...
    • A multicentre study of the evidence for customized margins in photon breast boost radiotherapy. 

      Harris, EJ; Mukesh, MB; Donovan, EM; Kirby, AM; Haviland, JS; Jena, R; Yarnold, J; Baker, A; Dean, J; Eagle, S; Mayles, H; Griffin, C; Perry, R; Poynter, A; Coles, CE; Evans, PM; IMPORT high trialists (2016-01)
      Objective To determine if subsets of patients may benefit from smaller or larger margins when using laser setup and bony anatomy verification of breast tumour bed (TB) boost radiotherapy (RT).Methods Verification imaging ...
    • A narrative review of oligometastatic prostate cancer-an evolving paradigm. 

      Sritharan, K; Rieu, R; Tree, A (2021-03-15)
      There has been growing interest in oligometastatic prostate cancer (OMPC) with a mounting body of evidence to suggest that it is a distinct disease state, both biologically and prognostically, when compared to polymetastatic ...
    • A new method for the high-precision assessment of tumor changes in response to treatment. 

      Tar, PD; Thacker, NA; Babur, M; Watson, Y; Cheung, S; Little, RA; Gieling, RG; Williams, KJ; O'Connor, JPB (2018-08)
      Motivation:Imaging demonstrates that preclinical and human tumors are heterogeneous, i.e. a single tumor can exhibit multiple regions that behave differently during both development and also in response to treatment. The ...
    • A novel amplitude binning strategy to handle irregular breathing during 4DMRI acquisition: improved imaging for radiotherapy purposes. 

      van Kesteren, Z; van der Horst, A; Gurney-Champion, OJ; Bones, I; Tekelenburg, D; Alderliesten, T; van Tienhoven, G; Klaassen, R; van Laarhoven, HWM; Bel, A (2019-05-14)
      Background For radiotherapy of abdominal cancer, four-dimensional magnetic resonance imaging (4DMRI) is desirable for tumor definition and the assessment of tumor and organ motion. However, irregular breathing gives rise ...
    • A novel approach to evaluate spatial resolution of MRI clinical images for optimization and standardization of breast screening protocols. 

      Borri, M; Scurr, ED; Richardson, C; Usher, M; Leach, MO; Schmidt, MA (2016-12)
      Purpose Stringent quality assurance is required in MRI breast screening to ensure that different scanners and imaging protocols reach similar diagnostic performance. The authors propose a methodology, based on power spectrum ...
    • A novel probabilistic approach to generating PTV with partial voxel contributions. 

      Tsang, HS; Kamerling, CP; Ziegenhein, P; Nill, S; Oelfke, U (2017-06)
      Radiotherapy treatment planning for use with high-energy photon beams currently employs a binary approach in defining the planning target volume (PTV). We propose a margin concept that takes the beam directions into account, ...
    • A novel serum protein signature associated with resistance to epidermal growth factor receptor tyrosine kinase inhibitors in head and neck squamous cell carcinoma. 

      Box, C; Mendiola, M; Gowan, S; Box, GM; Valenti, M; Brandon, ADH; Al-Lazikani, B; Rogers, SJ; Wilkins, A; Harrington, KJ; Eccles, SA (2013-07)
      Background Acquired resistance to tyrosine kinase inhibitors (TKIs) is becoming a major challenge in the treatment of many cancers. Epidermal growth factor receptor (EGFR) is overexpressed in squamous carcinomas, notably ...
    • A paradox: urgent BRCA genetic testing. 

      Mitchell, G; Ardern-Jones, A; Kissin Mchir, M; Taylor, R; Eeles, RA (2001-01)
      Diagnostic or predictive testing for germline mutations in cancer predisposition genes is inherently slow as result of both genetic counselling and mutation analysis. The overall time taken for mutation testing is not ...
    • A phase-I trial of pre-operative, margin intensive, stereotactic body radiation therapy for pancreatic cancer: the 'SPARC' trial protocol. 

      Holyoake, DLP; Ward, E; Grose, D; McIntosh, D; Sebag-Montefiore, D; Radhakrishna, G; Patel, N; Silva, M; Mukherjee, S; Strauss, VY; Odondi, L; Fokas, E; Melcher, A; Hawkins, MA (2016-09-13)
      Background Standard therapy for borderline-resectable pancreatic cancer in the UK is surgery with adjuvant chemotherapy, but rates of resection with clear margins are unsatisfactory and overall survival remains poor. ...
    • A pooling project of studies participating in the National Cancer Institute Cohort Consortium. 

      Swerdlow, A; schoemaker, M; wright, LB; brook, MN; jones, ME
    • A practical guide to the handling and administration of talimogene laherparepvec in Europe. 

      Harrington, KJ; Michielin, O; Malvehy, J; Pezzani Grüter, I; Grove, L; Frauchiger, AL; Dummer, R (2017-01)
      Talimogene laherparepvec is a herpes simplex virus-1-based intralesional oncolytic immunotherapy and is the first oncolytic virus to be approved in Europe. It is indicated for the treatment of adults with unresectable ...
    • A preclinical microbeam facility with a conventional x-ray tube. 

      Bartzsch, S; Cummings, C; Eismann, S; Oelfke, U (2016-12)
      Purpose Microbeam radiation therapy is an innovative treatment approach in radiation therapy that uses arrays of a few tens of micrometer wide and a few hundreds of micrometer spaced planar x-ray beams as treatment fields. ...