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dc.contributor.authorSud, A
dc.contributor.authorCooke, R
dc.contributor.authorSwerdlow, AJ
dc.contributor.authorHoulston, RS
dc.date.accessioned2017-09-21T09:01:18Z
dc.date.issued2015-09-22
dc.identifier.citationScientific reports, 2015, 5 pp. 14315 - ?
dc.identifier.issn2045-2322
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/833
dc.identifier.eissn2045-2322en_US
dc.identifier.doi10.1038/srep14315en_US
dc.description.abstractRecent studies have reported that regions of homozygosity (ROH) in the genome are detectable in outbred populations and can be associated with an increased risk of malignancy. To examine whether homozygosity is associated with an increased risk of developing Hodgkin lymphoma (HL) we analysed 589 HL cases and 5,199 controls genotyped for 484,072 tag single nucleotide polymorphisms (SNPs). Across the genome the cumulative distribution of ROH was not significantly different between cases and controls. Seven ROH at 4q22.3, 4q32.2, 7p12.3-14.1, 7p22.2, 10p11.22-23, 19q13.12-2 and 19p13.2 were associated with HL risk at P < 0.01. Intriguingly 4q22.3 harbours an ROH to which the nuclear factor NF-kappa-B p105 subunit (NFKB1) maps (P = 0.002). The ROH at 19q13.12-2 has previously been implicated in B-cell precursor acute lymphoblastic leukaemia. Aside from these observations which require validation, it is unlikely that levels of measured homozygosity caused by autozygosity, uniparental isodisomy or hemizygosity play a major role in defining HL risk in predominantly outbred populations.
dc.formatElectronic
dc.format.extent14315 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectHodgkin Disease
dc.subjectPopulation Surveillance
dc.subjectRisk
dc.subjectCase-Control Studies
dc.subjectGene Frequency
dc.subjectGenotype
dc.subjectHomozygote
dc.subjectGenes, Recessive
dc.subjectPolymorphism, Single Nucleotide
dc.subjectGenome-Wide Association Study
dc.subjectUnited Kingdom
dc.titleGenome-wide homozygosity signature and risk of Hodgkin lymphoma.
dc.typeJournal Article
dcterms.dateAccepted2015-08-25
rioxxterms.versionofrecord10.1038/srep14315
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2015-09-22en_US
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfScientific reports
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.publication-statusPublished
pubs.volume5en_US
pubs.embargo.termsNot known
icr.researchteamAetiological Epidemiologyen_US
icr.researchteamCancer Genomicsen_US
dc.contributor.icrauthorHoulston, Richarden
dc.contributor.icrauthorSwerdlow, Anthonyen
dc.contributor.icrauthorSud, Amiten


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