Genome-wide homozygosity signature and risk of Hodgkin lymphoma.
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Date
2015-09-22Author
Sud, A
Cooke, R
Swerdlow, AJ
Houlston, RS
Type
Journal Article
Metadata
Show full item recordAbstract
Recent studies have reported that regions of homozygosity (ROH) in the genome are detectable in outbred populations and can be associated with an increased risk of malignancy. To examine whether homozygosity is associated with an increased risk of developing Hodgkin lymphoma (HL) we analysed 589 HL cases and 5,199 controls genotyped for 484,072 tag single nucleotide polymorphisms (SNPs). Across the genome the cumulative distribution of ROH was not significantly different between cases and controls. Seven ROH at 4q22.3, 4q32.2, 7p12.3-14.1, 7p22.2, 10p11.22-23, 19q13.12-2 and 19p13.2 were associated with HL risk at P < 0.01. Intriguingly 4q22.3 harbours an ROH to which the nuclear factor NF-kappa-B p105 subunit (NFKB1) maps (P = 0.002). The ROH at 19q13.12-2 has previously been implicated in B-cell precursor acute lymphoblastic leukaemia. Aside from these observations which require validation, it is unlikely that levels of measured homozygosity caused by autozygosity, uniparental isodisomy or hemizygosity play a major role in defining HL risk in predominantly outbred populations.
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Subject
Humans
Hodgkin Disease
Population Surveillance
Risk
Case-Control Studies
Gene Frequency
Genotype
Homozygote
Genes, Recessive
Polymorphism, Single Nucleotide
Genome-Wide Association Study
United Kingdom
Research team
Aetiological Epidemiology
Cancer Genomics
Language
eng
Date accepted
2015-08-25
License start date
2015-09-22
Citation
Scientific reports, 2015, 5 pp. 14315 - ?
Publisher
NATURE PORTFOLIO