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Candidate gene association studies and risk of Hodgkin lymphoma: a systematic review and meta-analysis.

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Date
2017-03
ICR Author
Houlston, Richard
Sud, Amit
Author
Sud, A
Hemminki, K
Houlston, RS
Type
Journal Article
Metadata
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Abstract
To evaluate the contribution of association studies of candidate polymorphisms to inherited predisposition to Hodgkin lymphoma (HL), we conducted a systematic review and meta-analysis of published case-control studies. Of the variants examined more than once in candidate gene association studies, we identified 21 studies that reported on 12 polymorphic variants in 10 genes. Data were also extracted from a published genome wide association study to allow analysis of an additional 47 variants in a further 30 genes. Promising associations were seen in nine of the variants (p < 0.05). Given that the estimated false positive report probabilities (FPRPs) for all associations are high (i.e. FPRP > 0.2), these findings should be interpreted with caution. While studies of candidate polymorphisms may be an attractive means of identifying risk factors for HL, future studies should employ sample sizes adequately powered to identify variants having only modest effects on HL risk. Furthermore, because of aetiological heterogeneity within HL, stratification of genotyping according to age, tumour Epstein-Barr virus status and histology is essential. Copyright © 2015 John Wiley & Sons, Ltd.
URI
https://repository.icr.ac.uk/handle/internal/835
DOI
https://doi.org/10.1002/hon.2235
Collections
  • Genetics and Epidemiology
Subject
Immune System
Humans
Hodgkin Disease
Genetic Predisposition to Disease
False Positive Reactions
Probability
Odds Ratio
Risk Factors
Case-Control Studies
DNA Repair
Gene Expression Regulation, Neoplastic
Genotype
Polymorphism, Genetic
Genome-Wide Association Study
Research team
Cancer Genomics
Language
eng
Date accepted
2015-04-13
License start date
2017-03
Citation
Hematological oncology, 2017, 35 (1), pp. 34 - 50

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