dc.contributor.author | Sud, A | |
dc.contributor.author | Kinnersley, B | |
dc.contributor.author | Houlston, RS | |
dc.date.accessioned | 2017-11-23T16:18:36Z | |
dc.date.issued | 2017-11-01 | |
dc.identifier.citation | Nature reviews. Cancer, 2017, 17 (11), pp. 692 - 704 | |
dc.identifier.issn | 1474-175X | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/942 | |
dc.identifier.eissn | 1474-1768 | |
dc.identifier.doi | 10.1038/nrc.2017.82 | |
dc.description.abstract | Genome-wide association studies (GWAS) provide an agnostic approach for investigating the genetic basis of complex diseases. In oncology, GWAS of nearly all common malignancies have been performed, and over 450 genetic variants associated with increased risks have been identified. As well as revealing novel pathways important in carcinogenesis, these studies have shown that common genetic variation contributes substantially to the heritable risk of many common cancers. The clinical application of GWAS is starting to provide opportunities for drug discovery and repositioning as well as for cancer prevention. However, deciphering the functional and biological basis of associations is challenging and is in part a barrier to fully unlocking the potential of GWAS. | |
dc.format | Print-Electronic | |
dc.format.extent | 692 - 704 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PORTFOLIO | |
dc.rights.uri | https://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
dc.subject | Humans | |
dc.subject | Neoplasms | |
dc.subject | Antineoplastic Agents | |
dc.subject | Genome-Wide Association Study | |
dc.title | Genome-wide association studies of cancer: current insights and future perspectives. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2017-08-07 | |
rioxxterms.funder | The Institute of Cancer Research | |
rioxxterms.identifier.project | Unspecified | |
rioxxterms.versionofrecord | 10.1038/nrc.2017.82 | |
rioxxterms.licenseref.uri | https://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
rioxxterms.licenseref.startdate | 2017-11 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nature reviews. Cancer | |
pubs.issue | 11 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.publication-status | Published | |
pubs.volume | 17 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Cancer Genomics | |
dc.contributor.icrauthor | Sud, Amit | |
dc.contributor.icrauthor | Kinnersley, Benjamin | |
dc.contributor.icrauthor | Houlston, Richard | |