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dc.contributor.authorSud, A
dc.contributor.authorKinnersley, B
dc.contributor.authorHoulston, RS
dc.date.accessioned2017-11-23T16:18:36Z
dc.date.issued2017-11
dc.identifier.citationNature reviews. Cancer, 2017, 17 (11), pp. 692 - 704
dc.identifier.issn1474-175X
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/942
dc.identifier.eissn1474-1768
dc.identifier.doi10.1038/nrc.2017.82
dc.description.abstractGenome-wide association studies (GWAS) provide an agnostic approach for investigating the genetic basis of complex diseases. In oncology, GWAS of nearly all common malignancies have been performed, and over 450 genetic variants associated with increased risks have been identified. As well as revealing novel pathways important in carcinogenesis, these studies have shown that common genetic variation contributes substantially to the heritable risk of many common cancers. The clinical application of GWAS is starting to provide opportunities for drug discovery and repositioning as well as for cancer prevention. However, deciphering the functional and biological basis of associations is challenging and is in part a barrier to fully unlocking the potential of GWAS.
dc.formatPrint-Electronic
dc.format.extent692 - 704
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectAntineoplastic Agents
dc.subjectGenome-Wide Association Study
dc.titleGenome-wide association studies of cancer: current insights and future perspectives.
dc.typeJournal Article
dcterms.dateAccepted2017-08-07
rioxxterms.funderThe Institute of Cancer Research
rioxxterms.identifier.projectUnspecified
rioxxterms.versionofrecord10.1038/nrc.2017.82
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.licenseref.startdate2017-11
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature reviews. Cancer
pubs.issue11
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.publication-statusPublished
pubs.volume17
pubs.embargo.termsNot known
icr.researchteamCancer Genomicsen_US
dc.contributor.icrauthorHoulston, Richarden
dc.contributor.icrauthorKinnersley, Benjaminen
dc.contributor.icrauthorSud, Amiten


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