Genome-wide association studies of cancer: current insights and future perspectives.
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Date
2017-11-01Author
Sud, A
Kinnersley, B
Houlston, RS
Type
Journal Article
Metadata
Show full item recordAbstract
Genome-wide association studies (GWAS) provide an agnostic approach for investigating the genetic basis of complex diseases. In oncology, GWAS of nearly all common malignancies have been performed, and over 450 genetic variants associated with increased risks have been identified. As well as revealing novel pathways important in carcinogenesis, these studies have shown that common genetic variation contributes substantially to the heritable risk of many common cancers. The clinical application of GWAS is starting to provide opportunities for drug discovery and repositioning as well as for cancer prevention. However, deciphering the functional and biological basis of associations is challenging and is in part a barrier to fully unlocking the potential of GWAS.
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Subject
Humans
Neoplasms
Antineoplastic Agents
Genome-Wide Association Study
Research team
Cancer Genomics
Language
eng
Date accepted
2017-08-07
License start date
2017-11
Citation
Nature reviews. Cancer, 2017, 17 (11), pp. 692 - 704
Publisher
NATURE PORTFOLIO